CDO1 - cysteine dioxygenase type 1 Gene

Also Known as CDO-I

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 1036

About CDO1

Cytogenetic location: 5q22.3 Genomic coordinates (GRCh38): 5:115,804,733-115,816,659 (from NCBI)

This gene has 4 transcripts (splice variants) and 206 orthologues. Biased expression in liver (RPKM 94.6), fat (RPKM 66.8) and 8 other tissues.

Summary

Predicted to enable cysteine dioxygenase activity and ferrous iron binding activity. Predicted to be involved in L-cysteine catabolic process. Predicted to be located in cytosol. [provided by Alliance of Genome Resources, Apr 2022]

CDO1 Products (4)

mRNA	Protein	Name
NM_001323565.2	NP_001310494.1	cysteine dioxygenase type 1 isoform 1
NM_001323566.2	NP_001310495.1	cysteine dioxygenase type 1 isoform 3
NM_001323567.2	NP_001310496.1	cysteine dioxygenase type 1 isoform 4
NM_001801.3	NP_001792.2	cysteine dioxygenase type 1 isoform 2

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables cysteine dioxygenase activity	IDA IDA: Inferred from direct assay	17135237	GOA
enables ferrous iron binding	IDA IDA: Inferred from direct assay	17135237	GOA
enables zinc ion binding	IDA IDA: Inferred from direct assay	17135237	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CDO1 Protein Structure

CDO_I

0
100
200 a.a.

Protein Preferred Names	Protein Names
cysteine dioxygenase type 1	cysteine dioxygenase, type I

Recombinant CDO1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P70066	CDO1/Cysteine dioxygenase type 1 Protein, Human (His)	Q16878 (M1-N200)	≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases	Alias
Hepatoblastoma
Barrett Esophagus	Barrett'S Esophagus Barrett Esophagus/Esophageal Adenocarcinoma Barrett Metaplasia Barrett'S Ulcer Of Esophagus Ulcerative Esophagitis Barrett'S Esophagus With Esophagitis Barrett'S Oesophagus Barretts Syndrome Barrett Syndrome BE Peptic Ulcer Of Esophagus Adenocarcinoma Of Esophagus
Large Intestine Adenocarcinoma	Adenocarcinoma Of Large Intestine
Tinea Unguium	Dermatophytosis Of Nail Onychomycosis Due To Dermatophyte Cellulitis And Abscess Cellulitis And Abscess Of Buttock Cellulitis And Abscess Of Face Cellulitis And Abscess Of Finger Cellulitis And Abscess Of Finger And Toe Cellulitis And Abscess Of Gluteal Region Cellulitis And Abscess Of Trunk Cellulitis And Abscess Of Upper Arm And Forearm Dermatophytic Onychia Dermatophytic Onychomycosis Onychomycosis Ringworm Of Nails Tinea Of Nail
Atrial Septal Defect 1	ASD1 Atrial Heart Septal Defect 1 Asd

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-160525	NVS-VHL720	Degrader	98.63%	Unkown
HY-RS02421	CDO1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17328	Cdo1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23783	Cdo1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	CDO1	VGNC	VGNC:60715
Macaca mulatta	CDO1	VGNC	VGNC:110475
Canis familiaris	CDO1	VGNC	VGNC:39075
Mus musculus	CDO1	MGD	MGI:105925
Rattus norvegicus	CDO1	RGD	RGD:69262
Bos taurus	CDO1	VGNC	VGNC:27150
Others	CDO1	NCBI