NVS-VHL785
NVS-VHL785 is a VHL-binding molecular glue that selectively degrades CDO1. NVS-VHL785 recruits CDO1 to the VHL-cullin-RING ubiquitin ligase complex, inducing ubiquitin-proteasome-dependent degradation of CDO1. NVS-VHL785 can be used for research related to CDO1-mediated diseases.
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 1448189-67-0
- 分子式: C23H30N4O4S
- 分子量:458.57
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
製品説明
体外実験
NVS‑VHL785 induces CDO1‑VHL ternary complex assembly in the TR‑FRET biochemical assay (AC50 =194 nM) and the cellular NanoBiT assay (AC50 =701 nM)[1].
NVS‑VHL785 directly binds the VHL protein, with a binary binding KD =220 nM measured by SPR; the VHL‑compound 7‑CDO1 ternary complex has an SPR KD =0.3 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 1448189-67-0
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分子量 458.57
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分子式 C23H30N4O4S
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SMILES
O=C([C@H]1N(C([C@@H](NC(C)=O)C(C)C)=O)C[C@H](O)C1)NCC2=CC=C(C3=C(C)N=CS3)C=C2
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
NVS-VHL785 関連分類
HY-190187 関連分類
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