PPIE - peptidylprolyl isomerase E Gene

Also Known as CYP33; CYP-33

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 10450

About PPIE

Cytogenetic location: 1p34.2 Genomic coordinates (GRCh38): 1:39,738,882-39,763,914 (from NCBI)

This gene has 15 transcripts (splice variants), 189 orthologues and 22 paralogues. Ubiquitous expression in thyroid (RPKM 9.0), testis (RPKM 7.1) and 25 other tissues.

Summary

The protein encoded by this gene is a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family. PPIases catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerate the folding of proteins. This protein contains a highly conserved Cyclophilin (CYP) domain as well as an RNA-binding domain. It was shown to possess PPIase and protein folding activities, and it also exhibits RNA-binding activity. Alternative splicing results in multiple transcript variants. A related pseudogene, which is also located on chromosome 1, has been identified. [provided by RefSeq, Aug 2010]

PPIE Products (4)

mRNA Protein Name
NM_001195007.2 NP_001181936.1 peptidyl-prolyl cis-trans isomerase E isoform 4
NM_001319293.2 NP_001306222.1 peptidyl-prolyl cis-trans isomerase E isoform 5
NM_006112.4 NP_006103.1 peptidyl-prolyl cis-trans isomerase E isoform 1
NM_203456.3 NP_982281.1 peptidyl-prolyl cis-trans isomerase E isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables mRNA binding IDA
IDA: Inferred from direct assay
18258190 GOA
enables peptidyl-prolyl cis-trans isomerase activity IDA
IDA: Inferred from direct assay
18258190 GOA
enables poly(A) binding IDA
IDA: Inferred from direct assay
18258190 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
11313484 GOA
Biological Process GO Annotation Evidence References Source
involved in mRNA splicing, via spliceosome IDA
IDA: Inferred from direct assay
28076346 GOA
involved in positive regulation of viral genome replication IMP
IMP: Inferred from mutant phenotype
19932913 GOA
involved in regulation of DNA-templated transcription IMP
IMP: Inferred from mutant phenotype
11313484 GOA
Cellular Component GO Annotation Evidence References Source
part of U2-type catalytic step 2 spliceosome IDA
IDA: Inferred from direct assay
28076346 GOA
part of catalytic step 2 spliceosome IDA
IDA: Inferred from direct assay
11991638 GOA
located in nucleus IDA
IDA: Inferred from direct assay
11313484 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PPIE Protein Structure

RRM_1

RRM_1: RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) (8 - 78)

Pro_isomerase

Pro_isomerase: Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD (143 - 298)

  • 0
  • 100
  • 200
  • 301 a.a.
Protein Preferred Names Protein Names

peptidyl-prolyl cis-trans isomerase E

  • PPIase E

PPIE Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Cross
PPIE Q9UNP9 S Human coronavirus NL63 Q6Q1S2
P8 Filamentous Phage
34799561
Cross
PPIE Q9UNP9 S Human coronavirus NL63 Q6Q1S2
Phage Display
37100772
Intra
PPIE Q9UNP9 AQR Homo sapiens O60306
TAP
24981860
Intra
PPIE Q9UNP9 AQR Homo sapiens O60306
Anti Tag CoIP
33961781
Intra
PPIE Q9UNP9 XAB2 Homo sapiens Q9HCS7
Validated Y2H
25416956
Intra
PPIE Q9UNP9 XAB2 Homo sapiens Q9HCS7
Anti Tag CoIP
33961781
Intra
PPIE Q9UNP9 XAB2 Homo sapiens Q9HCS7
Y2H Array
25416956
Intra
PPIE Q9UNP9 XAB2 Homo sapiens Q9HCS7
Anti Tag CoIP
22365833
Intra
PPIE Q9UNP9 XAB2 Homo sapiens Q9HCS7
Y2H Pooling
16189514
Intra
PPIE Q9UNP9 XAB2 Homo sapiens Q9HCS7
TAP
24981860
Intra
PPIE Q9UNP9 XAB2 Homo sapiens Q9HCS7
Y2H
22365833
Intra
PPIE Q9UNP9 XAB2 Homo sapiens Q9HCS7
Y2H Prey Pooling
25416956
Intra
PPIE Q9UNP9 FGFR3 Homo sapiens P22607
Y2H Pooling
32814053
Intra
PPIE Q9UNP9 FGFR3 Homo sapiens P22607
Validated Y2H
32814053
Intra
PPIE Q9UNP9 FGFR3 Homo sapiens P22607
Y2H Array
32814053
Intra
PPIE Q9UNP9 GSN Homo sapiens P06396
Y2H Array
32814053
Intra
PPIE Q9UNP9 GSN Homo sapiens P06396
Validated Y2H
32814053
Intra
PPIE Q9UNP9 GSN Homo sapiens P06396
Y2H Pooling
32814053
Intra
PPIE Q9UNP9 KMT2A Homo sapiens Q03164
GMS
20541251
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant PPIE Proteins

Cat. No. Product Name Accession Purity
HY-P71225 PPIE Protein, Human (His) Q9UNP9 (M1-V301) ≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Voyeurism
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS10950 PPIE Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20328 Ppie Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26836 Ppie Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus PPIE RGD RGD:1311411
Macaca mulatta PPIE VGNC VGNC:81509
Canis familiaris PPIE VGNC VGNC:44852
Bos taurus PPIE VGNC VGNC:55661
Mus musculus PPIE MGD MGI:1917118
Others PPIE NCBI