IFITM2 - interferon induced transmembrane protein 2 Gene

Also Known as 1-8D; DSPA2c

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 10581

About IFITM2

Cytogenetic location: 11p15.5 Genomic coordinates (GRCh38): 11:307,816-309,395 (from NCBI)

This gene has 23 transcripts (splice variants), 246 orthologues and 4 paralogues. Ubiquitous expression in appendix (RPKM 262.7), spleen (RPKM 209.9) and 23 other tissues.

Summary

Interferon-induced transmembrane (IFITM) proteins are a family of interferon induced Antiviral proteins. The family contains five members, including IFITM1, IFITM2 and IFITM3 and belong to the CD225 superfamily. The protein encoded by this gene restricts cellular entry by diverse viral pathogens, such as influenza A virus, Ebola virus and Sars-CoV-2. [provided by RefSeq, Nov 2021]

IFITM2 Products (1)

mRNA	Protein	Name
NM_006435.3	NP_006426.2	interferon-induced transmembrane protein 2

Gene Ontology

Biological Process
Cellular Component

Biological Process GO Annotation	Evidence	References	Source
involved in cellular response to interferon-beta	IDA IDA: Inferred from direct assay	33563656	GOA
involved in negative regulation of viral entry into host cell	IDA IDA: Inferred from direct assay	21253575	GOA
involved in negative regulation of viral genome replication	IDA IDA: Inferred from direct assay	21253575	GOA
involved in response to interferon-alpha	IDA IDA: Inferred from direct assay	22479637	GOA
involved in response to interferon-beta	IDA IDA: Inferred from direct assay	21253575	GOA
involved in response to type II interferon	IDA IDA: Inferred from direct assay	21253575	GOA
involved in response to virus	IDA IDA: Inferred from direct assay	20943977	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in late endosome membrane	IDA IDA: Inferred from direct assay	26354436	GOA
located in lysosomal membrane	IDA IDA: Inferred from direct assay	26354436	GOA
part of protein-containing complex	IDA IDA: Inferred from direct assay	28246125	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

IFITM2 Protein Structure

CD225

0
100
132 a.a.

Protein Preferred Names	Protein Names
interferon-induced transmembrane protein 2	dispanin subfamily A member 2c

Related Diseases

Diseases	Alias
Influenza	Flu Influenza With Non-Respiratory Manifestation Influenza With Other Manifestations Influenza, Human Influenza, Susceptibility To Seasonal Influenza, Virus Identified
West Nile Virus	West Nile Virus, Susceptibility To Wnv Wnv, Susceptibility To West Nile Viral Infection Encephalitis, West Nile Fever West Nile Fever
Dengue Virus	Dengue Virus, Susceptibility To Dengue Fever, Protection Against Dengue Fever
Stomatitis
Rift Valley Fever	Rfv - [Rift Valley Fever]
Inflammatory Bowel Disease	Inflammatory Bowel Diseases Bowel Disease, Inflammatory

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06567	IFITM2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21869	Ifitm2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P992379	IB001	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	IFITM2	MGD	MGI:1933382
Rattus norvegicus	IFITM2	RGD	RGD:69332
Others	IFITM2	NCBI