Ovol2 - ovo like zinc finger 2 Gene

Also Known as MOVO; Ovo2; M-OVO; movo2; Zfp339; M-OVO-A; M-OVO-B; 1700108N11Rik; 1810007D21Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 107586

Summary

Enables DNA binding activity; DNA-binding transcription factor activity, RNA polymerase II-specific; and chromatin binding activity. Involved in several processes, including negative regulation of epithelial to mesenchymal transition; regulation of SMAD protein signal transduction; and regulation of gene expression. Acts upstream of or within several processes, including circulatory system development; embryonic morphogenesis; and regulation of transcription, DNA-templated. Located in nucleus. Is expressed in several structures, including early conceptus; genitourinary system; gut; head surface ectoderm; and otocyst. Human ortholog(s) of this gene implicated in posterior polymorphous corneal dystrophy 1. Orthologous to human OVOL2 (ovo like zinc finger 2). [provided by Alliance of Genome Resources, Apr 2022]

Ovol2 Products (2)

mRNA Protein Name
NM_026924.3 NP_081200.2 transcription factor Ovo-like 2 isoform A
NM_152947.2 NP_694455.2 transcription factor Ovo-like 2 isoform B

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables DNA binding IDA
IDA: Inferred from direct assay
15225875 MGI
enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
IDA: Inferred from direct assay
24735878 MGI
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IDA
IDA: Inferred from direct assay
28455959 MGI
enables chromatin binding IDA
IDA: Inferred from direct assay
24735878 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within angiogenesis IMP
IMP: Inferred from mutant phenotype
17573777 MGI
acts upstream of cell population proliferation IMP
IMP: Inferred from mutant phenotype
16423343 MGI
acts upstream of or within dorsal/ventral pattern formation IMP
IMP: Inferred from mutant phenotype
16423343 MGI
acts upstream of or within embryonic digestive tract morphogenesis IMP
IMP: Inferred from mutant phenotype
16423343 MGI
acts upstream of or within endocardium formation IMP
IMP: Inferred from mutant phenotype
17573777 MGI
involved in epidermal cell differentiation IMP
IMP: Inferred from mutant phenotype
24735879 MGI
acts upstream of or within epidermis development IGI
IGI: Inferred from genetic interaction
24735878 MGI
acts upstream of or within heart development IMP
IMP: Inferred from mutant phenotype
16423343 MGI
acts upstream of or within heart looping IMP
IMP: Inferred from mutant phenotype
17573777 MGI
acts upstream of or within heart trabecula formation IMP
IMP: Inferred from mutant phenotype
17573777 MGI
acts upstream of or within labyrinthine layer blood vessel development IMP
IMP: Inferred from mutant phenotype
17573777 MGI
involved in negative regulation of SMAD protein signal transduction IDA
IDA: Inferred from direct assay
28455959 MGI
acts upstream of or within negative regulation of cell population proliferation IMP
IMP: Inferred from mutant phenotype
16423343 MGI
involved in negative regulation of epithelial to mesenchymal transition IDA
IDA: Inferred from direct assay
28455959 MGI
involved in negative regulation of epithelial to mesenchymal transition IMP
IMP: Inferred from mutant phenotype
24735879 MGI
involved in negative regulation of gene expression IDA
IDA: Inferred from direct assay
28455959 MGI
acts upstream of or within negative regulation of stem cell proliferation IGI
IGI: Inferred from genetic interaction
24735878 MGI
involved in negative regulation of transforming growth factor beta receptor signaling pathway IDA
IDA: Inferred from direct assay
28455959 MGI
acts upstream of or within neural crest cell migration IMP
IMP: Inferred from mutant phenotype
16423343 MGI
acts upstream of or within neural fold formation IMP
IMP: Inferred from mutant phenotype
16423343 MGI
involved in positive regulation of gene expression IDA
IDA: Inferred from direct assay
28455959 MGI
acts upstream of or within positive regulation of keratinocyte differentiation IDA
IDA: Inferred from direct assay
24735878 MGI
involved in regulation of keratinocyte proliferation IMP
IMP: Inferred from mutant phenotype
19700410 MGI
Cellular Component GO Annotation Evidence References Source
located in nucleus IDA
IDA: Inferred from direct assay
9468311 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

transcription factor Ovo-like 2

  • MOVO-B zinc finger protein

  • MOVO-C zinc finger protein

  • OVO homolog-like 2

  • ovo-like 2

  • zinc finger OVO2

  • zinc finger protein 339

  • zinc finger protein mOVO

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS09884 OVOL2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22705 Ovol2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS29219 Ovol2 Rat Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ovol2 NCBI NCBI:58495