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OVOL2 - ovo like zinc finger 2 Gene

Also Known as CHED; CHED1; CHED2; PPCD1; ZNF339; EUROIMAGE566589

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 58495

About OVOL2

Cytogenetic location: 20p11.23 Genomic coordinates (GRCh38): 20:18,024,152-18,059,188 (from NCBI)

This gene has 5 transcripts (splice variants), 202 orthologues, 29 paralogues and is associated with 4 phenotypes. Broad expression in stomach (RPKM 6.1), colon (RPKM 3.5) and 15 other tissues.

Summary

This gene encodes a member of the evolutionarily conserved ovo-like protein family. Mammalian members of this family contain a single zinc finger domain composed of a tetrad of C2H2 zinc fingers with variable N- and C-terminal extensions that contain intrinsically disordered domains. Members of this family are involved in epithelial development and differentiation. Knockout of this gene in mouse results in early embryonic lethality with phenotypes that include neurectoderm expansion, impaired vascularization, and heart anomalies. In humans, allelic variants of this gene have been associated with posterior polymorphous corneal dystrophy. [provided by RefSeq, Apr 2016]

OVOL2 Products (3)

mRNA	Protein	Name
NM_001303461.1	NP_001290390.1	transcription factor Ovo-like 2 isoform 2
NM_001303462.1	NP_001290391.1	transcription factor Ovo-like 2 isoform 2
NM_021220.4	NP_067043.2	transcription factor Ovo-like 2 isoform 1

OVOL2 Protein Structure

zf-H2C2_2

zf-C2H2

0
100
200
275 a.a.

Protein Preferred Names	Protein Names
transcription factor Ovo-like 2	corneal endothelial dystrophy 1 (autosomal dominant)

OVOL2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	OVOL2	Q9BRP0	ZNF526	Homo sapiens	Q8TF50	Y2H Array	32296183
Intra	OVOL2	Q9BRP0	ZNF526	Homo sapiens	Q8TF50	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Corneal Dystrophy, Posterior Polymorphous, 1	Posterior Polymorphous Corneal Dystrophy Ppcd Maumenee Corneal Dystrophy Posterior Polymorphous Corneal Dystrophy 1 PPCD1 Corneal Dystrophy, Hereditary Polymorphous Posterior Corneal Endothelial Dystrophy 1, Autosomal Dominant Schlichting Dystrophy Ched1 Corneal Endothelial Dystrophy 1, Autosomal Dominant, Formerly Ched1, Formerly Hereditary Polymorphus Posterior Corneal Dystrophy Posterior Polymorphous Dystrophy Hereditary Polymorphous Posterior Corneal Dystrophy Dystrophy, Corneal, Posterior Polymorphous Dystrophy, Corneal, Posterior Polymorphous, Type 1 Polymorphous Corneal Dystrophy Corneal Endothelial Dystrophy 2
Congenital Hereditary Endothelial Dystrophy Type I	Autosomal Dominant Ched Autosomal Dominant Congenital Hereditary Endothelial Dystrophy Ched1 Chedi Congenital Hereditary Endothelial Dystrophy Type 1 Corneal Endothelial Dystrophy 1, Autosomal Dominant
Corneal Endothelial Dystrophy	Congenital Hereditary Endothelial Dystrophy Of Cornea Chandler Syndrome CHED Chandler'S Syndrome Endothelial Corneal Dystrophy Ched2 Maumenee Corneal Dystrophy Corneal Dystrophy, Congenital Hereditary Endothelial Dystrophy Of Corneal Endothelium Corneal Endothelial Dystrophy 2 Corneal Endothelial Dystrophy 2, Autosomal Recessive, Formerly Ched2, Formerly Corneal Endothelial Dystrophy, Autosomal Recessive Endothelial Dystrophy Posterior Membrane Corneal Dystrophy Corneal Endothelial Dystrophy Type 2 Congenital Hereditary Endothelial Dystrophy Of The Cornea Congenital Hereditary Endothelial Dystrophy Type Ii Autosomal Recessive Ched Autosomal Recessive Congenital Hereditary Endothelial Dystrophy Chedii Congenital Hereditary Endothelial Dystrophy Type 2 Infantile Hereditary Endothelial Dystrophy Congenital Hereditary Endothelial Corneal Dystrophy Corneal Endothelial Dystrophy 2, Autosomal Recessive Iridocorneal Endothelial Syndrome Dystrophy, Corneal, Endothelial Corneal Endothelial Dystrophy 1, Autosomal Dominant
Corneal Dystrophy
Rare Corneal Disorder
Corneal Dystrophy, Posterior Polymorphous, 3	Posterior Polymorphous Corneal Dystrophy 3 PPCD3 Dystrophy, Corneal, Posterior Polymorphous, Type 3
Corneal Dystrophy, Posterior Polymorphous, 4	PPCD4 Posterior Polymorphous Corneal Dystrophy 4
Cogan-Reese Syndrome
Corneal Edema	Corneal Oedema Infiltrate Of Cornea
Tyrosinemia, Type Ii	Tyrosinemia Type Ii Oculocutaneous Tyrosinemia Richner-Hanhart Syndrome Tyrosine Aminotransferase Deficiency Tat Deficiency Tyrosine Transaminase Deficiency Keratosis Palmoplantaris With Corneal Dystrophy TYRSN2 Oregon Type Tyrosinemia Tyrosinemia Type 2 Tyrosinosis Oculocutaneous Type Tyrosinosis, Oculocutaneous Type Richner Hanhart Syndrome Keratosis Palmoplantaris-Corneal Dystrophy Syndrome Tyrosinemia Due To Tat Deficiency Tyrosinemia Due To Tyrosine Aminotransferase Deficiency Tyrosinemia 2 Tyrosinemia Oregon Type Tyrosine Transaminase Deficiency Disease
Fuchs' Endothelial Dystrophy	Fuchs Endothelial Corneal Dystrophy Fuchs Endothelial Dystrophy Fuchs Dystrophy Fced Fuchs' Corneal Dystrophy Fuchs' Endothelial Corneal Dystrophy Fuchs Atrophy Fuchs Corneal Dystrophy Endoepithelial Corneal Dystrophy Fecd Late Hereditary Endothelial Dystrophy Corneal Dystrophy, Fuchs Endothelial Dystrophy, Corneal, Fuchs Endothelial Corneal Dystrophy, Fuchs' Endothelial, 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09884	OVOL2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS22705	Ovol2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS29219	Ovol2 Rat Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	OVOL2	MGD	MGI:1338039
Canis familiaris	OVOL2	VGNC	VGNC:44197
Rattus norvegicus	OVOL2	RGD	RGD:1306130
Macaca mulatta	OVOL2	VGNC	VGNC:107849
Bos taurus	OVOL2	VGNC	VGNC:32506
Felis catus	OVOL2	VGNC	VGNC:64006
Others	OVOL2	NCBI