Mylk - myosin, light polypeptide kinase Gene

Also Known as KRP; Mlck; nmMlck; smMLCK; MLCK108; MLCK210; 9530072E15Rik; A930019C19Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 107589

Summary

Enables enzyme binding activity. Involved in tonic smooth muscle contraction. Acts upstream of or within cellular response to calcium ion; cellular response to potassium ion; and cellular response to xenobiotic stimulus. Located in cell-cell junction. Is expressed in several structures, including central nervous system; heart; liver; and retina. Human ortholog(s) of this gene implicated in adult respiratory distress syndrome; asthma; and thoracic aortic aneurysm. Orthologous to human MYLK (Myosin light chain kinase). [provided by Alliance of Genome Resources, Apr 2022]

Mylk Products (4)

mRNA Protein Name
NM_001408261.1 NP_001395190.1 myosin light chain kinase, smooth muscle isoform 1
NM_001408262.1 NP_001395191.1 myosin light chain kinase, smooth muscle isoform 3
NM_001408263.1 NP_001395192.1 myosin light chain kinase, smooth muscle isoform 4
NM_139300.4 NP_647461.3 myosin light chain kinase, smooth muscle isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables enzyme binding IPI
IPI: Inferred from physical interaction
21074048 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
15102471 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within cellular response to calcium ion IDA
IDA: Inferred from direct assay
18524939 MGI
acts upstream of or within cellular response to potassium ion IDA
IDA: Inferred from direct assay
18524939 MGI
acts upstream of or within cellular response to xenobiotic stimulus IDA
IDA: Inferred from direct assay
18524939 MGI
involved in neurotransmitter receptor transport to postsynaptic membrane IDA
IDA: Inferred from direct assay
26330558 MGI
involved in smooth muscle contraction IMP
IMP: Inferred from mutant phenotype
18586037 MGI
involved in tonic smooth muscle contraction IMP
IMP: Inferred from mutant phenotype
20018858 MGI
Cellular Component GO Annotation Evidence References Source
located in cell-cell junction IDA
IDA: Inferred from direct assay
23793062 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

myosin light chain kinase, smooth muscle

  • kinase-related protein

  • telokin

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (11)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-176882 ASK1-IN-11 Inhibitor / Unkown
HY-RS08923 MYLK Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS08924 MYLK2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS08925 MYLK3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS08926 MYLK4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18624 Mylk Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22661 Mylk3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22662 Mylk4 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25110 Mylk Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS29175 Mylk3 Rat Pre-designed siRNA Set A / Unkown
HY-RS29176 Mylk4 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Mylk NCBI NCBI:4638