Cth - cystathionase (cystathionine gamma-lyase) Gene

Also Known as CGL; CSE; Cys3; 0610010I13Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 107869

Summary

Enables L-cystine L-cysteine-lyase (deaminating) and cystathionine gamma-lyase activity. Involved in several processes, including positive regulation of I-kappaB kinase/NF-kappaB signaling; positive regulation of NF-kappaB transcription factor activity; and protein sulfhydration. Acts upstream of or within cellular response to Leukemia Inhibitory Factor and negative regulation of apoptotic signaling pathway. Predicted to be located in cytosol. Predicted to be active in cytoplasm. Is expressed in several structures, including alimentary system; central nervous system; cranium; ear; and genitourinary system. Used to study cystathioninuria. Human ortholog(s) of this gene implicated in amino acid metabolic disorder and cystathioninuria. Orthologous to human CTH (cystathionine gamma-lyase). [provided by Alliance of Genome Resources, Apr 2022]

Cth Products (2)

mRNA Protein Name
NM_145953.2 NP_666065.1 cystathionine gamma-lyase
NM_145953.2 NP_666065.1 cystathionine gamma-lyase

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables L-cystine L-cysteine-lyase (deaminating) IDA
IDA: Inferred from direct assay
22244329 MGI
enables L-cystine L-cysteine-lyase (deaminating) IMP
IMP: Inferred from mutant phenotype
19903941 MGI
enables cystathionine gamma-lyase activity IDA
IDA: Inferred from direct assay
15038791 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
19903941 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within cellular response to leukemia inhibitory factor IEP
IEP: Inferred from expression pattern
20439489 MGI
involved in negative regulation of apoptotic process IMP
IMP: Inferred from mutant phenotype
22244329 MGI
acts upstream of or within negative regulation of apoptotic signaling pathway IMP
IMP: Inferred from mutant phenotype
22244329 MGI
involved in positive regulation of NF-kappaB transcription factor activity IMP
IMP: Inferred from mutant phenotype
22244329 MGI
involved in positive regulation of canonical NF-kappaB signal transduction IMP
IMP: Inferred from mutant phenotype
22244329 MGI
involved in protein sulfhydration IDA
IDA: Inferred from direct assay
22244329 MGI
involved in protein sulfhydration IMP
IMP: Inferred from mutant phenotype
19903941 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

cystathionine gamma-lyase

  • cysteine desulfhydrase

  • cysteine-protein sulfhydrase

  • homocysteine desulfhydrase

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS03296 CTH Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-181717 TKL002 98.08% Unkown
HY-RS15708 VSIG2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17261 Cth Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23715 Cth Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Cth NCBI NCBI:1491