Grm7 - glutamate receptor, metabotropic 7 Gene

Also Known as SMN2; Gpr1g; Gprc1g; mGluR7; C030018L03; 6330570A01Rik; E130018M02Rik; Tg(SMN2)89Ahmb

Species: Mus musculus

Gene Type: protein coding
Gene ID: 108073

About Grm7

Chromosome 6: 110,622,542-111,544,191 forward strand.GRCm39:CM000999.3

This gene has 5 transcripts (splice variants), 280 orthologues, 7 paralogues and is associated with 22 phenotypes. Biased expression in cortex adult (RPKM 6.5), frontal lobe adult (RPKM 4.9) and 6 other tissues.

Summary

Enables Calcium Channel regulator activity and voltage-gated Calcium Channel activity. Involved in chemical synaptic transmission and regulation of synaptic vesicle exocytosis. Acts upstream of or within several processes, including behavioral fear response; learning or memory; and transmission of nerve impulse. Located in glutamatergic synapse and presynaptic membrane. Is expressed in several structures, including alimentary system; brain; eye; reproductive system; and spinal cord. Orthologous to human GRM7 (glutamate metabotropic receptor 7). [provided by Alliance of Genome Resources, Apr 2022]

Grm7 Products (2)

mRNA Protein Name
NM_001346640.1 NP_001333569.1 metabotropic glutamate receptor 7 isoform 2 precursor
NM_177328.3 NP_796302.2 metabotropic glutamate receptor 7 isoform 1 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables calcium channel regulator activity IDA
IDA: Inferred from direct assay
11584003 MGI
enables voltage-gated calcium channel activity IDA
IDA: Inferred from direct assay
12065412 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within adult behavior IMP
IMP: Inferred from mutant phenotype
12814372 MGI
acts upstream of or within associative learning IMP
IMP: Inferred from mutant phenotype
16775145 MGI
acts upstream of or within behavioral fear response IMP
IMP: Inferred from mutant phenotype
9920659 MGI
involved in chemical synaptic transmission IDA
IDA: Inferred from direct assay
12065412 MGI
acts upstream of or within conditioned taste aversion IMP
IMP: Inferred from mutant phenotype
9920659 MGI
acts upstream of or within memory IMP
IMP: Inferred from mutant phenotype
16204199 MGI
acts upstream of or within multicellular organismal response to stress IMP
IMP: Inferred from mutant phenotype
12814372 MGI
acts upstream of or within nervous system process IMP
IMP: Inferred from mutant phenotype
16204199 MGI
involved in presynaptic modulation of chemical synaptic transmission EXP
EXP: Inferred from Experiment
12065412 MGI
involved in presynaptic modulation of chemical synaptic transmission IDA
IDA: Inferred from direct assay
12065412 MGI
acts upstream of or within short-term memory IMP
IMP: Inferred from mutant phenotype
15313036 MGI
acts upstream of or within transmission of nerve impulse IMP
IMP: Inferred from mutant phenotype
11698585 MGI
Cellular Component GO Annotation Evidence References Source
is active in glutamatergic synapse EXP
EXP: Inferred from Experiment
12065412 MGI
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
12065412 MGI
located in presynaptic membrane IDA
IDA: Inferred from direct assay
12065412 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Grm7 Protein Structure

PBP1_mGluR_groupIII

PBP1_mGluR_groupIII: cd06376 (42 - 510)

NCD3G

NCD3G: pfam07562 (518 - 568)

7tmC_mGluR7

7tmC_mGluR7: cd15451 (588 - 613)

7tmC_mGluR7

7tmC_mGluR7: cd15451 (588 - 894)

7tmC_mGluR7

7tmC_mGluR7: cd15451 (625 - 646)

7tmC_mGluR7

7tmC_mGluR7: cd15451 (655 - 679)

7tmC_mGluR7

7tmC_mGluR7: cd15451 (701 - 721)

7tmC_mGluR7

7tmC_mGluR7: cd15451 (751 - 777)

7tmC_mGluR7

7tmC_mGluR7: cd15451 (785 - 808)

7tmC_mGluR7

7tmC_mGluR7: cd15451 (818 - 843)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 915 a.a.
Protein Preferred Names Protein Names

metabotropic glutamate receptor 7

  • G protein-coupled receptor GRM7

  • G protein-coupled receptor, family C, group 1, member G

  • mGlu7a receptor

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS05837 GRM7 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS05838 Grm7 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS05839 Grm7 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Grm7 NCBI NCBI:2917