CHKA - choline kinase alpha Gene

Also Known as CK; EK; CHK; CKI; NEDMIMS

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 1119

About CHKA

Cytogenetic location: 11q13.2 Genomic coordinates (GRCh38): 11:68,052,859-68,121,388 (from NCBI)

This gene has 8 transcripts (splice variants), 206 orthologues and 3 paralogues. Broad expression in testis (RPKM 24.3), thyroid (RPKM 9.0) and 25 other tissues.

Summary

The major pathway for the biosynthesis of phosphatidylcholine occurs via the CDP-choline pathway. The protein encoded by this gene is the initial enzyme in the sequence and may play a regulatory role. The encoded protein also catalyzes the phosphorylation of ethanolamine. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

CHKA Products (6)

mRNA Protein Name
NM_001277.3 NP_001268.2 choline kinase alpha isoform a
NM_001376219.1 NP_001363148.1 choline kinase alpha isoform c
NM_001376220.1 NP_001363149.1 choline kinase alpha isoform d
NM_001376221.1 NP_001363150.1 choline kinase alpha isoform e
NM_001376222.1 NP_001363151.1 choline kinase alpha isoform f
NM_212469.2 NP_997634.1 choline kinase alpha isoform b

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables choline kinase activity IDA
IDA: Inferred from direct assay
19915674 GOA
enables ethanolamine kinase activity IDA
IDA: Inferred from direct assay
19915674 GOA
enables protein binding IDA
IDA: Inferred from direct assay
34077757 GOA
enables protein homodimerization activity IDA
IDA: Inferred from direct assay
34077757 GOA
enables protein tyrosine kinase activity IDA
IDA: Inferred from direct assay
34077757 GOA
Biological Process GO Annotation Evidence References Source
involved in cellular response to glucose starvation IDA
IDA: Inferred from direct assay
34077757 GOA
acts upstream of positive effect lipid droplet disassembly IDA
IDA: Inferred from direct assay
34077757 GOA
involved in phosphatidylcholine biosynthetic process IDA
IDA: Inferred from direct assay
19915674 GOA
involved in phosphatidylethanolamine biosynthetic process IDA
IDA: Inferred from direct assay
19915674 GOA
Cellular Component GO Annotation Evidence References Source
is active in cytosol IDA
IDA: Inferred from direct assay
19915674 GOA
located in lipid droplet IDA
IDA: Inferred from direct assay
34077757 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CHKA Protein Structure

Choline_kinase

Choline_kinase: Choline/ethanolamine kinase (139 - 374)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 457 a.a.
Protein Preferred Names Protein Names

choline kinase alpha

  • CHETK-alpha

Related Diseases

Diseases Alias
Neurodevelopmental Disorder With Microcephaly, Movement Abnormalities, And Seizures

  • NEDMIMS
Muscular Lipidosis

  • Lipid Storage Myopathy
Hepatitis C Virus

  • Hepatitis C Virus, Susceptibility To

  • Hepatitis C Virus Infection, Response To Therapy Of

  • Hcv

  • Hcv, Susceptibility To

  • Hepatitis C Virus, Resistance To

  • Hepatitis C Virus, Response To Therapy Of

  • Resistance To Hepatitis C Virus
Neuroleptic Malignant Syndrome
Cecal Benign Neoplasm

  • Cecal Neoplasms

  • Cecum Neoplasm

  • Neoplasm Of Caecum

  • Cecal Neoplasm

  • Cecum Carcinoma

  • Malignant Neoplasm Of Cecum
Cecum Adenoma

  • Caecum Adenoma
Microcephaly

  • Microencephaly

  • Microcephalus

  • Microcephalic

  • Nanocephaly

  • Congenital Microcephaly

  • Brain Hypoplasia

  • Brain Nondevelopment

  • Cephalic Hypoplasia

  • Undeveloped Cerebrum

  • Undeveloped Brain

  • Micrencephalon

  • Micrencephaly
Pycnodysostosis

  • Pyknodysostosis

  • PKND

  • Pycd

  • Toulouse-Lautrec Syndrome
Liver Rhabdomyosarcoma

  • Rhabdomyosarcoma Of Liver
Gastric Cardia Carcinoma

  • Carcinoma Of Cardia Of Stomach
Muscular Dystrophy, Congenital, Megaconial Type

  • Megaconial Type Congenital Muscular Dystrophy

  • Congenital Megaconial Myopathy

  • Congenital Muscular Dystrophy Due To Phosphatidylcholine Biosynthesis Defect

  • Congenital Muscular Dystrophy With Mitochondrial Structural Abnormalities

  • Megaconial Congenital Muscular Dystrophy

  • MDCMC

  • Muscular Dystrophy, Congenital, With Mitochondrial Structural Abnormalities

  • Megaconial Congénital Muscular Dystrophy

  • Dystrophy, Muscular, Congenital, Megaconial Type
Myopathy

  • Muscular Diseases

  • Myopathies
Hemoglobin D Disease

  • Hb-D Disease

  • Punjab Disease

  • Los Angeles Disease

  • Hb D Los Angeles Disease

  • Hb D Punjab Disease
Prostate Cancer

  • Prostate Carcinoma

  • Prostate Cancer, Familial

  • Prostate Neoplasm

  • Prostate Cancer, Somatic

  • Prostate Cancer, Susceptibility To

  • Prostatic Cancer

  • Prostatic Neoplasms

  • Hereditary Prostate Cancer

  • Prostatic Neoplasm

  • Cancer Of Prostate

  • Carcinoma Of Prostate

  • Familial Prostate Cancer

  • Familial Prostate Carcinoma

  • Malignant Tumor Of Prostate

  • Malignant Neoplasm Of Prostate

  • Prostate Cancer, Familial, Susceptibility To

  • Malignant Tumor Of The Prostate

  • Ngp - New Growth Of Prostate

  • Tumor Of The Prostate

  • Prostate Cancer, Hereditary

  • Cancer Of The Prostate

  • Malignant Neoplasm Of The Prostate

  • Prostatic Carcinoma

  • PC

  • Prca

  • Cancer, Prostate

  • Malignant Prostatic Tumour

  • Malignant Tumour Of Prostate

  • Primary Prostate Cancer

  • Primary Malignant Neoplasm Of Prostate

  • Prostate Gland Cancer
Joubert Syndrome 32

  • JBTS32
Choline Deficiency Disease

  • Choline Deficiency
Myocardial Infarction

  • Heart Attack

  • Myocardial Infarction, Susceptibility To

  • Myocardial Infarction 1

  • Myocardial Infarction, Protection Against

  • Myocardial Infarction, Decreased Susceptibility To

  • Myocardial Infarction, Decreased

  • Myocardial Infarct

  • MCI1

  • Premature Myocardial Infarction

  • Myocardial Infarction, Susceptibility To, Type 1
Bladder Cancer

  • Urinary Bladder Cancer

  • Bladder Carcinoma

  • Urinary Bladder Carcinoma

  • Bladder Neoplasm

  • Bladder Tumor

  • Cancer, Bladder

  • Malignant Neoplasm Of Urinary Bladder

  • Carcinoma Of Bladder

  • Bladder Cancer, Somatic

  • Tumor Of The Bladder

  • Carcinoma Of Urinary Bladder

  • Bladder Carcinoma Urinary

  • Cancer Of The Urinary Bladder

  • Cancer, Urinary Bladder

  • Malignant Bladder Neoplasm

  • Malignant Bladder Tumor

  • Neoplasm Of The Bladder

  • Neoplasm Of The Urinary Bladder

  • Tumor Of The Urinary Bladder

  • Urinary Bladder Neoplasm

  • BLC

  • Urothelial Carcinoma Of The Bladder

  • Bladder Tumors

  • Urinary Bladder Neoplasms

  • Bladder Cancer Nos

  • Vesical Cancer Nos

  • Malignant Neoplasm Of Bladder, Part Unspecified

  • Malignant Tumour Of Urinary Bladder

  • Primary Malignant Neoplasm Of Bladder
Microinvasive Gastric Cancer

  • Early Gastric Cancer

  • Surface Gastric Cancer
Focal Segmental Glomerulosclerosis

  • Familial Idiopathic Steroid-Resistant Nephrotic Syndrome

  • Focal Glomerulosclerosis

  • Fsgs

  • Segmental Glomerulosclerosis

  • Glomerulosclerosis, Focal Segmental

  • Fgs

  • Focal Glomerular Sclerosis

  • Familial Idiopathic Nephrotic Syndrome

  • Focal Sclerosis With Hyalinosis

  • Glomerulosclerosis, Focal

  • Glomerulosclerosis Focal

  • Glomerulosclerosis, Segmental, Focal

  • Focal Segmental Glomerulosclerosis, Not Otherwise Specified
Heart Disease

  • Heart Failure

  • Congenital Heart Disease

  • Heart Diseases

  • Congenital Heart Defects

  • Congenital Heart Defect

  • Heart Malformation

  • Congenital Anomaly Of Heart

  • Heart Defect

  • Heart-Congenital Defect

  • Congenital Heart Disorder

  • Heart Defects Congenital

  • Heart Defects, Congenital

  • Heart Defects

  • Heart Disease, Congenital

  • Disease, Heart, Congenital

  • Congestive Heart Failure
Glycogen Storage Disease

  • Glycogenosis

  • Glycogenoses

  • Gsd

  • Storage Disease, Glycogen

  • Gsd - [Glycogen Storage Disease]

  • Glycogen Thesaurismosis

  • Diffuse Glycogenosis

  • Generalised Glycogen Storage Disease

  • Generalised Glycogenosis

  • Generalised Glycogen Storage Disease Of Infants

  • Glycogen Synthase Deficiency
Muscular Dystrophy

  • Muscular Dystrophies

  • Congenital Md

  • Congenital Muscular Dystrophy

  • Cmd

  • Mdc

  • Dystrophy, Muscular

  • Gower'S Muscular Dystrophy

  • Progressive Musclular Dystrophy

  • Pseudohypertrophic Atrophy

  • Pseudohypertrophic Muscle Paralysis

  • Pseudohypertrophic Muscular Atrophy

  • Pseudohypertrophic Muscular Dystrophy

  • Pseudohypertrophic Paralysis

  • Pseudomuscular Hypertrophy
Breast Cancer

  • Breast Carcinoma

  • Male Breast Cancer

  • Breast Cancer, Familial

  • Malignant Neoplasm Of Breast

  • Breast Cancer, Susceptibility To

  • Breast Cancer, Early-Onset

  • Malignant Tumor Of Breast

  • Carcinoma Of Male Breast

  • Breast Cancer, Invasive Ductal

  • Breast Cancer, Protection Against

  • Breast Cancer, Somatic

  • Breast Cancer, Male

  • Breast Cancer, Lobular, Somatic

  • Breast Tumor

  • Mammary Cancer

  • Mammary Tumor

  • Malignant Neoplasm Of Male Breast

  • Mammary Carcinoma

  • Male Breast Carcinoma

  • Familial Cancer Of Breast

  • Invasive Ductal Breast Carcinoma

  • Breast Cancer Susceptibility

  • Breast Cancer, Male, Susceptibility To

  • Breast Cancer, Early-Onset, Susceptibility To

  • Malignant Tumor Of The Breast

  • Mammary Neoplasm

  • Primary Breast Cancer

  • Neoplasm Of Male Breast

  • Carcinoma Of Breast

  • Breast Cancer In Men

  • Familial Breast Cancer

  • Cancer Of Breast

  • BC

  • Breast Cancer Familial

  • Breast Cancer Familial Male

  • Breast Cancer, Familial Male

  • Breast Male Carcinoma

  • Breast Neoplasms

  • Breast Neoplasms, Male

  • Mammary Tumors

  • Mammary Carcinomas

  • Cancer, Breast

  • Cancer, Breast, Susceptibility

  • Invasive Breast Ductal Carcinoma

  • Breast Neoplasm

  • Susceptibility To Breast Cancer

  • Mammary Neoplasms

  • Animal Mammary Neoplasms

  • Primary Malignant Neoplasm Of Breast

  • Infiltrating Ductal Carcinoma Of Breast

  • Infiltrating Duct Carcinoma Of Unspecified Site

  • Infiltrating Ductular Carcinoma Of Unspecified Site

  • Invasive Breast Carcinoma Of No Special Type

  • Microinvasive Carcinoma Of Breast

  • Carcinoma With Apocrine Differentiation
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS02633 CHKA Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21311 Chka Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27830 Chka Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus CHKA VGNC VGNC:60860
Macaca mulatta CHKA VGNC VGNC:71039
Mus musculus CHKA MGD MGI:107760
Rattus norvegicus CHKA RGD RGD:61944
Canis familiaris CHKA VGNC VGNC:39218
Bos taurus CHKA VGNC VGNC:27295
Others CHKA NCBI