Chek2 - checkpoint kinase 2 Gene

Also Known as Chk2; Rad53

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 114212

About Chek2

Primary_assembly 12: 45,788,827-45,821,286 reverse strand.mRatBN7.2:CM026985.1

This gene has 2 transcripts (splice variants), 206 orthologues and is associated with 61 phenotypes. Biased expression in Thymus (RPKM 6.6), Spleen (RPKM 55.8) and 9 other tissues.

Summary

Enables protein serine/threonine kinase activity. Involved in several processes, including cellular response to bisphenol A; positive regulation of anoikis; and regulation of cell cycle phase transition. Located in nucleus. Biomarker of urinary bladder Cancer. Human ortholog(s) of this gene implicated in several diseases, including Li-Fraumeni syndrome 2; breast Cancer (multiple); colorectal cancer; osteosarcoma; and prostate Cancer. Orthologous to human CHEK2 (checkpoint kinase 2). [provided by Alliance of Genome Resources, Apr 2022]

Chek2 Products (1)

mRNA Protein Name
NM_053677.1 NP_446129.1 serine/threonine-protein kinase Chk2

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables kinase activity IDA
IDA: Inferred from direct assay
10435585 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
19812253 RGD
enables protein kinase activity IDA
IDA: Inferred from direct assay
11278490 RGD
enables protein serine/threonine kinase activity IDA
IDA: Inferred from direct assay
10435585 RGD
Biological Process GO Annotation Evidence References Source
involved in DNA damage checkpoint signaling IMP
IMP: Inferred from mutant phenotype
10435585 RGD
involved in cellular response to bisphenol A IEP
IEP: Inferred from expression pattern
25344109 RGD
involved in cellular response to xenobiotic stimulus IEP
IEP: Inferred from expression pattern
21745814 RGD
involved in negative regulation of DNA damage checkpoint IMP
IMP: Inferred from mutant phenotype
20637979 RGD
involved in peptidyl-serine phosphorylation IDA
IDA: Inferred from direct assay
10435585 RGD
involved in positive regulation of anoikis IMP
IMP: Inferred from mutant phenotype
21834075 RGD
involved in positive regulation of protein phosphorylation IDA
IDA: Inferred from direct assay
18162465 RGD
involved in positive regulation of protein phosphorylation IMP
IMP: Inferred from mutant phenotype
18162465 RGD
involved in protein phosphorylation IDA
IDA: Inferred from direct assay
11278490 RGD
involved in response to glycoside IEP
IEP: Inferred from expression pattern
19801496 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Chek2 Protein Structure

FHA_CHK2

FHA_CHK2: cd22666 (95 - 206)

STKc_Chk2

STKc_Chk2: cd14084 (215 - 488)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 545 a.a.
Protein Preferred Names Protein Names

serine/threonine-protein kinase Chk2

  • CHK2 checkpoint homolog

  • protein kinase Chk2

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-173147 CDK2-IN-42 Inhibitor / Unkown
HY-RS02619 CHEK2 Human Pre-designed siRNA Set A / Unkown
HY-RS02620 Chek2 Mouse Pre-designed siRNA Set A / Unkown
HY-RS02621 Chek2 Rat Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Chek2 NCBI NCBI:11200