2. Gene
  3. Chek2 - checkpoint kinase 2 Gene

Chek2 - checkpoint kinase 2 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as Chk2; Rad53

Gene ID: 114212 | Gene type: protein coding

About Chek2

Primary_assembly 12: 45,788,827-45,821,286 reverse strand.mRatBN7.2:CM026985.1

This gene has 2 transcripts (splice variants), 206 orthologues and is associated with 61 phenotypes. Biased expression in Thymus (RPKM 6.6), Spleen (RPKM 55.8) and 9 other tissues.

Summary

Enables protein serine/threonine kinase activity. Involved in several processes, including cellular response to bisphenol A; positive regulation of anoikis; and regulation of cell cycle phase transition. Located in nucleus. Biomarker of urinary bladder Cancer. Human ortholog(s) of this gene implicated in several diseases, including Li-Fraumeni syndrome 2; breast Cancer (multiple); colorectal cancer; osteosarcoma; and prostate Cancer. Orthologous to human CHEK2 (checkpoint kinase 2). [provided by Alliance of Genome Resources, Apr 2022]

Chek2 Products(1)

mRNA Protein Name
NM_053677.1 NP_446129.1 serine/threonine-protein kinase Chk2

Chek2 Protein Structure

FHA_CHK2

FHA_CHK2: cd22666 (95 - 206)

STKc_Chk2

STKc_Chk2: cd14084 (215 - 488)

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  • 545 a.a.
Protein Preferred Names Protein Names

serine/threonine-protein kinase Chk2

CHK2 checkpoint homolog

protein kinase Chk2

Related Agents

Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS02619 CHEK2 Human Pre-designed siRNA Set A / Unkown
HY-RS02620 Chek2 Mouse Pre-designed siRNA Set A / Unkown
HY-RS02621 Chek2 Rat Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Chek2 NCBI NCBI:11200
Mus musculus Chek2 NCBI NCBI:50883