CHEK2 - checkpoint kinase 2 Gene

Also Known as CDS1; CHK2; LFS2; RAD53; hCds1; HuCds1; PP1425

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 11200

About CHEK2

Cytogenetic location: 22q12.1 Genomic coordinates (GRCh38): 22:28,687,743-28,741,834 (from NCBI)

This gene has 25 transcripts (splice variants), 206 orthologues and is associated with 124 phenotypes. Ubiquitous expression in bone marrow (RPKM 3.3), lymph node (RPKM 3.1) and 24 other tissues.

Summary

In response to DNA damage and replication blocks, cell cycle progression is halted through the control of critical cell cycle regulators. The protein encoded by this gene is a cell cycle checkpoint regulator and putative tumor suppressor. It contains a forkhead-associated protein interaction domain essential for activation in response to DNA damage and is rapidly phosphorylated in response to replication blocks and DNA damage. When activated, the encoded protein is known to inhibit CDC25C Phosphatase, preventing entry into Mitosis, and has been shown to stabilize the tumor suppressor protein p53, leading to cell cycle arrest in G1. In addition, this protein interacts with and phosphorylates BRCA1, allowing BRCA1 to restore survival after DNA damage. Mutations in this gene have been linked with Li-Fraumeni syndrome, a highly penetrant familial Cancer phenotype usually associated with inherited mutations in TP53. Also, mutations in this gene are thought to confer a predisposition to sarcomas, breast Cancer, and brain tumors. This nuclear protein is a member of the CDS1 subfamily of serine/threonine protein kinases. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012]

CHEK2 Products (24)

mRNA	Protein	Name
XM_006724114.4	XP_006724177.3	serine/threonine-protein kinase Chk2 isoform X12
XM_047441105.1	XP_047297061.1	serine/threonine-protein kinase Chk2 isoform X5
XM_017028560.2	XP_016884049.1	serine/threonine-protein kinase Chk2 isoform X2
XM_011529845.3	XP_011528147.1	serine/threonine-protein kinase Chk2 isoform X15
XM_011529840.4	XP_011528142.1	serine/threonine-protein kinase Chk2 isoform X4
NM_001257387.2	NP_001244316.1	serine/threonine-protein kinase Chk2 isoform d
XM_011529842.3	XP_011528144.1	serine/threonine-protein kinase Chk2 isoform X10
XM_024452148.2	XP_024307916.1	serine/threonine-protein kinase Chk2 isoform X6
XR_937807.3
XR_007067954.1
NM_001005735.2	NP_001005735.1	serine/threonine-protein kinase Chk2 isoform c
XR_007067955.1
XM_006724116.3	XP_006724179.2	serine/threonine-protein kinase Chk2 isoform X14
XM_047441108.1	XP_047297064.1	serine/threonine-protein kinase Chk2 isoform X13
XM_047441104.1	XP_047297060.1	serine/threonine-protein kinase Chk2 isoform X3
NM_001349956.2	NP_001336885.1	serine/threonine-protein kinase Chk2 isoform e
XM_011529839.3	XP_011528141.1	serine/threonine-protein kinase Chk2 isoform X1
XR_937806.3
XM_047441106.1	XP_047297062.1	serine/threonine-protein kinase Chk2 isoform X7
XM_047441107.1	XP_047297063.1	serine/threonine-protein kinase Chk2 isoform X8
XM_024452149.2	XP_024307917.1	serine/threonine-protein kinase Chk2 isoform X9
NM_007194.4	NP_009125.1	serine/threonine-protein kinase Chk2 isoform a
XM_011529844.3	XP_011528146.1	serine/threonine-protein kinase Chk2 isoform X11
NM_145862.2	NP_665861.1	serine/threonine-protein kinase Chk2 isoform b

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	16794575	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	11298456	GOA
enables protein homodimerization activity	IDA IDA: Inferred from direct assay	16794575	GOA
enables protein kinase binding	IPI IPI: Inferred from physical interaction	16481012	GOA
enables protein serine/threonine kinase activity	IDA IDA: Inferred from direct assay	12717439	GOA
enables ubiquitin protein ligase binding	IPI IPI: Inferred from physical interaction	22266820	GOA

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within DNA damage response	IDA IDA: Inferred from direct assay	24550317	GOA
involved in DNA damage response	IMP IMP: Inferred from mutant phenotype	16481012	GOA
involved in G2/M transition of mitotic cell cycle	IMP IMP: Inferred from mutant phenotype	16481012	GOA
involved in cellular response to stress	IDA IDA: Inferred from direct assay	37943659	GOA
involved in double-strand break repair	IMP IMP: Inferred from mutant phenotype	18317453	GOA
involved in intrinsic apoptotic signaling pathway in response to DNA damage	IDA IDA: Inferred from direct assay	12402044	GOA
involved in intrinsic apoptotic signaling pathway in response to DNA damage	IMP IMP: Inferred from mutant phenotype	12717439	GOA
involved in mitotic intra-S DNA damage checkpoint signaling	IMP IMP: Inferred from mutant phenotype	11298456	GOA
involved in mitotic spindle assembly	IMP IMP: Inferred from mutant phenotype	20364141	GOA
involved in positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	17101782	GOA
involved in protein autophosphorylation	IDA IDA: Inferred from direct assay	16794575	GOA
involved in protein catabolic process	IMP IMP: Inferred from mutant phenotype	11298456	GOA
involved in protein phosphorylation	IDA IDA: Inferred from direct assay	12717439	GOA
involved in protein stabilization	IDA IDA: Inferred from direct assay	12717439	GOA
involved in regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	12717439	GOA
involved in regulation of autophagosome assembly	IDA IDA: Inferred from direct assay	37943659	GOA
involved in regulation of protein catabolic process	IMP IMP: Inferred from mutant phenotype	17101782	GOA
acts upstream of or within signal transduction in response to DNA damage	IDA IDA: Inferred from direct assay	14744935	GOA
involved in signal transduction in response to DNA damage	IMP IMP: Inferred from mutant phenotype	11298456	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in PML body	IDA IDA: Inferred from direct assay	12402044	GOA
colocalizes with chromosome, telomeric region	IDA IDA: Inferred from direct assay	15149599	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CHEK2 Protein Structure

FHA

Pkinase

0
100
200
300
400
500
543 a.a.

Protein Preferred Names	Protein Names
serine/threonine-protein kinase Chk2	CHK2 checkpoint homolog cds1 homolog checkpoint-like protein CHK2

CHEK2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	CHEK2	O96017	MDM2	Homo sapiens	Q00987	Pull Down	15862297
Intra	CHEK2	O96017	KPNA2	Homo sapiens	P52292	TAP	23178491
Intra	CHEK2	O96017	CHEK2	Homo sapiens	O96017	X-Ray Diffraction	18239682
Intra	CHEK2	O96017	KPNA2	Homo sapiens	P52292	Y2H Array	12909615
Intra	CHEK2	O96017	CHEK2	Homo sapiens	O96017	Crosslink	16794575
Intra	CHEK2	O96017	PPP2R5A	Homo sapiens	Q15172	Y2H	15380617
Intra	CHEK2	O96017	PPP2R5A	Homo sapiens	Q15172	Pull Down	15380617
Intra	CHEK2	O96017	CHEK2	Homo sapiens	O96017	Protein Kinase Assay	16794575
Intra	CHEK2	O96017	PLK1	Homo sapiens	P53350	Protein Kinase Assay	12493754
Intra	CHEK2	O96017	MDM2	Homo sapiens	Q00987	Anti Bait CoIP	15862297
Intra	CHEK2	O96017	CHEK2	Homo sapiens	O96017	Crosslink	18239682
Intra	CHEK2	O96017	KPNA2	Homo sapiens	P52292	Anti Bait CoIP	12909615
Intra	CHEK2	O96017	MDM2	Homo sapiens	Q00987	Experimental Interac	15862297
Intra	CHEK2	O96017	KPNA2	Homo sapiens	P52292	Anti Tag CoIP	12909615
Intra	CHEK2	O96017	PPP2R5C	Homo sapiens	Q13362-1	Pull Down	15380617
Intra	CHEK2	O96017	PPP2R5C	Homo sapiens	Q13362-2	Y2H	15380617
Intra	CHEK2	O96017	PPP2R5C	Homo sapiens	Q13362-3	Anti Tag CoIP	15380617
Intra	CHEK2	O96017	PPP2R5C	Homo sapiens	Q13362-3	Y2H	15380617
Intra	CHEK2	O96017	PPP2R5C	Homo sapiens	Q13362-3	Pull Down	15380617
Intra	CHEK2	O96017	PPP2R5B	Homo sapiens	Q15173	Y2H	15380617
Intra	CHEK2	O96017	RNF20	Homo sapiens	Q5VTR2	Anti Tag CoIP	25640309
Intra	CHEK2	O96017	RNF20	Homo sapiens	Q5VTR2	Y2H Array	25640309
Cross	CHEK2	O96017	P0C6X7-PRO_0000037319	Human SARS coronavirus	P0C6X7-PRO_0000037319	Y2H Pooling	22046132
Cross	CHEK2	O96017	P0C6X7-PRO_0000037319	Human SARS coronavirus	P0C6X7-PRO_0000037319	Lumier	22046132
Intra	CHEK2	O96017	USP7	Homo sapiens	Q93009	TAP	23178491
Intra	CHEK2	O96017	VCP	Homo sapiens	P55072	Anti Bait CoIP	17525332
Intra	CHEK2	O96017	VCP	Homo sapiens	P55072	Anti Tag CoIP	17525332
Intra	CHEK2	O96017	AATF	Homo sapiens	Q9NY61	Anti Bait CoIP	17157788
Intra	CHEK2	O96017	AATF	Homo sapiens	Q9NY61	Anti Tag CoIP	17157788
Intra	CHEK2	O96017	IL24	Homo sapiens	Q13007	Anti Tag CoIP	25640309
Intra	CHEK2	O96017	IL24	Homo sapiens	Q13007	Y2H Array	25640309
Intra	CHEK2	O96017	RB1	Homo sapiens	P06400	Protein Kinase Assay	17380128
Intra	CHEK2	O96017	RB1	Homo sapiens	P06400	Anti Tag CoIP	17380128
Intra	CHEK2	O96017	PPM1G	Homo sapiens	O15355	TAP	23178491
Intra	CHEK2	O96017	GINS2	Homo sapiens	Q9Y248	Anti Bait CoIP	17525332
Intra	CHEK2	O96017	GINS2	Homo sapiens	Q9Y248	Anti Tag CoIP	17525332
Intra	CHEK2	O96017	LRATD2	Homo sapiens	Q96KN1	Y2H Array	25640309
Intra	CHEK2	O96017	LRATD2	Homo sapiens	Q96KN1	Anti Tag CoIP	25640309
Intra	CHEK2	O96017	XRCC1	Homo sapiens	P18887	Anti Bait CoIP	18971944
Intra	CHEK2	O96017	XRCC1	Homo sapiens	P18887	Anti Tag CoIP	18971944
Intra	CHEK2	O96017	XRCC1	Homo sapiens	P18887	Pull Down	18971944
Intra	CHEK2	O96017	PPP2R5E	Homo sapiens	Q16537	Y2H	15380617
Cross	CHEK2	O96017	P27958-PRO_0000037577	Hepatitis C virus	P27958-PRO_0000037577	Anti Bait CoIP	18667510
Cross	CHEK2	O96017	P27958-PRO_0000037577	Hepatitis C virus	P27958-PRO_0000037577	Anti Tag CoIP	18667510
Cross	CHEK2	O96017	UL83	Human cytomegalovirus	P06725	Anti Bait CoIP	16477038

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant CHEK2 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P75349	CHEK2 Protein, Human (Active, sf9, GST)	O96017-1 (S2-L543)	≥ 90%, as determined by reducing SDS-PAGE.

CHEK2 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P80083	Chk2 Antibody (YA504)	WB, ICC/IF, IHC-P, IP	Human
HY-P80799	Phospho-Chk2 (Thr68) Antibody	WB, ICC/IF, IHC-P	Human, Mouse, Rat
HY-P83884	CHK2 Antibody (YA3581)	WB, IHC-P, ICC/IF, ELISA	Human
HY-P83884A	CHK2 Antibody (YA3581)(PBS only)	WB, IHC-P, ICC/IF, ELISA	Human
HY-P86494	Chk2 Antibody (YA6186)	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Transitional Cell Carcinoma	Transitional Cell Neoplasm Carcinoma, Transitional Cell Transitional Carcinoma Transitional Cell Tumor Urothelial Cell Carcinoma Carcinoma Transitional Cell Transitional Cell Carcinoma Of Bladder
Pancreatic Cancer	Pancreatic Carcinoma Familial Pancreatic Carcinoma Pancreatic Neoplasm Carcinoma Of Pancreas Pancreatic Carcinoma, Familial Malignant Neoplasm Of Pancreas Pancreatic Acinar Carcinoma Pancreatic Tumor Familial Pancreatic Cancer Neoplasm Of The Pancreas Pancreatic Carcinoma, Somatic Pancreatic Cancer, Somatic Ca Body Of Pancreas Ca Head Of Pancreas Ca Tail Of Pancreas Malignant Neoplasm Of Body Of Pancreas Malignant Neoplasm Of Head Of Pancreas Malignant Neoplasm Of Tail Of Pancreas Pancreas Neoplasm Exocrine Cancer Exocrine Pancreas Carcinoma Hereditary Pancreatic Cancer Hereditary Pancreatic Carcinoma PNCA Cancer Of The Pancreas Pancreatic Cancer, Susceptibility To Carcinoma Of Head Of Pancreas Pancreatic Neoplasms Pancreatic Tumors Cancer, Pancreatic Cancer Of Pancreas Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site
Autosomal Recessive Cerebellar Ataxia	Arca
Basal Cell Carcinoma	Basal Cell Cancer Basal Cell Neoplasm Basal Cell Carcinoma Of Skin Malignant Basal Cell Tumor Basal Cell Tumor Epithelioma Basal Cell Malignant Basal Cell Neoplasm Rodent Ulcer Carcinoma Basal Cell Neoplasms, Basal Cell Basal Cell Carcinomas Experimental Organism Basal Cell Carcinoma Nodulo-Ulcerative Basal Cell Carcinoma Basalioma Basal Cell Epithelioma Of Skin Bcc - [Basal Cell Carcinoma] Of Skin Rodent Ulcer Of Skin Rodent Ulcer Of Unspecified Site Basal Cell Epithelioma Of Unspecified Site
Nk-Cell Enteropathy
Lung Cancer	Lung Carcinoma Non-Small Cell Lung Carcinoma Lung Cancer, Protection Against Lung Cancer, Susceptibility To Adenocarcinoma Of Lung, Somatic Nonsmall Cell Lung Cancer Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In Lung Neoplasm Carcinoma Of Lung Lung Non-Small Cell Carcinoma Non-Small Cell Lung Cancer Nsclc Lung Neoplasms Malignant Neoplasm Of Lung Alveolar Cell Carcinoma Nonsmall Cell Lung Cancer, Somatic Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer, Susceptibility To Lung Cancer, Somatic Lung Cancer, Resistance To Cancer Of Lung Cancer Of Bronchus Cancer Of The Lung Lung Malignancies Lung Malignant Tumors Malignant Lung Tumor Malignant Tumor Of Lung Pulmonary Cancer Pulmonary Carcinoma Pulmonary Neoplasms Respiratory Carcinoma LNCR Adenocarcinoma Of Lung Neoplasm Of Lung Cancer Lung Carcinoma Non-Small Cell Lung Carcinoma, Non-Small-Cell Lung Lung Cancers Lung Carcinomas Cancer, Lung Cancer, Lung, Non-Small Cell Primary Malignant Neoplasm Of Lung Bronchioloalveolar Adenocarcinoma
Bone Osteosarcoma	Osteosarcoma Of Bone Primary Osteosarcoma Of Bone
Familial Ovarian Cancer	Familial Ovarian Carcinoma Familial Ovarian Malignant Tumor
Nervous System Disease	Abnormality Of The Nervous System Nervous System Diseases Nervous System Disorder
Diffuse Midline Glioma, H3 K27m-Mutant	Diffuse Intrinsic Pontine Glioma Dipg Infiltrative Brainstem Glioma
Hereditary Breast Ovarian Cancer Syndrome	Hereditary Breast And Ovarian Cancer Syndrome Brca1- And Brca2-Associated Hereditary Breast And Ovarian Cancer Breast And/Or Ovarian Cancer Breast And Ovarian Cancer Syndrome Hboc Syndrome Hereditary Breast And Ovarian Cancer Brca1- Brca2-Associated Hboc
Wilms Tumor 5	Wilms Tumor WT5 Wilms Tumor Susceptibility-5 Wilms Tumor And Radial Bilateral Aplasia Nephroblastoma Wilms' Tumor Wilms Tumor, Susceptibility To Wtsl Bilateral Radial Aplasia With Wilms Tumor Embryonal Adenosarcoma Embryonal Nephroma Kidney Wilms Tumor Kidney, Adenomyosarcoma, Embryonal Kidney, Carcinosarcoma, Embryonal Kidney, Embryoma Kidney, Embryonal Mixed Tumor Nephroma Renal Adenosarcoma Renal Cancer, Wilms Renal Wilms Tumor Tumor, Wilms Hereditary Susceptibility To Wilms Tumor 5
Sporadic Breast Cancer	Sporadic Breast Carcinoma
Adenoid Cystic Carcinoma	Adenocystic Carcinoma Cribriform Carcinoma Cylindroma Carcinoma Adenoid Cystic Carcinoma, Adenoid Cystic Adenoid Cystic Carcinoma Of Salivary Gland Eccrine Dermal Cylindroma Carcinoma, Cribriform
Colonic Benign Neoplasm	Colon Neoplasm Colonic Mass Colonic Tumor Neoplasm Of Colon Neoplasm Of The Colon Colonic Neoplasms Colon Cancer Colon Carcinoma Nos Colonic Cancer Metastatic Colon Cancer Nos
Osteogenic Sarcoma	Osteosarcoma OSRC Osteosarcoma, Somatic Neoplasms, Bone Tissue Bone Tissue Neoplasm Osteoid Sarcoma Skeletal Sarcoma Osteosarcoma Of Bone Bone Sarcoma
Squamous Cell Carcinoma	Epidermoid Carcinoma Squamous Cell Cancer Carcinoma, Squamous Cell Malignant Squamous Cell Tumor Squamous Carcinoma Squamous Cell Epithelioma Squamous Cell Skin Cancer Carcinoma Squamous Cell Neoplasms, Squamous Cell Squamous Cell Carcinoma - Category Malignant Squamous Cell Neoplasm Squamous Cell Carcinoma Of Skin
Esophageal Cancer	Esophageal Carcinoma Carcinoma Of Esophagus Esophageal Squamous Cell Carcinoma, Somatic Esophageal Carcinoma, Somatic Esophagus Cancer Gastric Cardia Adenocarcinoma Esophageal Neoplasms Esophageal Cancer, Somatic Cancer Of Esophagus Cancer Of Oesophagus Carcinoma Of Oesophagus Ca Lower Third Oesophagus Ca Middle Third Oesophagus Malignant Neoplasm Of Distal Third Of Esophagus Malignant Neoplasm Of Lower Third Of Oesophagus Malignant Neoplasm Of Middle Third Of Oesophagus Malignant Neoplasm Of Proximal Third Of Esophagus Malignant Neoplasm Of Upper Third Esophagus Malignant Tumor Of Abdominal Esophagus Malignant Tumor Of Distal Third Of Esophagus Malignant Tumor Of Proximal Third Of Esophagus Malignant Tumor Of The Middle Third Of The Esophagus ESCR Aerodigestive Tract Cancer Escc Esophageal Squamous Cell Carcinoma Cancer, Esophageal Malignant Neoplasm Of Esophagus Squamous Cell Carcinoma Of Esophagus Malignant Neoplasm Of Middle Third Of Esophagus
Diffuse Gastric Cancer	Hereditary Diffuse Gastric Adenocarcinoma Hereditary Diffuse Gastric Cancer Signet Cell Adenocarcinoma Signet Ring Cell Carcinoma Signet Ring Cell Gastric Carcinoma Signet Ring Gastric Carcinoma Fdgc Familial Diffuse Cancer Of Stomach Familial Diffuse Gastric Cancer Gastric Cancer, Familial Diffuse Gastric Cancer, Hereditary Diffuse Hdgc Hereditary Diffuse Cancer Of Stomach Diffuse Gastric Cancer Syndrome Cancer, Gastric, Diffuse Carcinoma, Signet Ring Cell Gastric Signet Ring Carcinoma
Ovarian Clear Cell Adenocarcinoma
Cowden Syndrome 1	Pten Hamartoma Tumor Syndrome Bannayan-Riley-Ruvalcaba Syndrome Lhermitte-Duclos Disease Bannayan-Zonana Syndrome Phts Riley-Smith Syndrome Bzs Ruvalcaba-Myhre-Smith Syndrome Multiple Hamartoma Syndrome Rmss Brrs Dysplastic Gangliocytoma Of The Cerebellum CWS1 Cs Cd Mham Pten Hamartoma Tumor Syndrome With Granular Cell Tumor Macrocephaly Multiple Lipomas And Hemangiomata Bannayan-Ruvalcaba-Riley Syndrome Myhre-Riley-Smith Syndrome LDD Cerebelloparenchymal Disorder Vi Hamartoma Syndrome, Multiple Bbrs Macrocephaly, Pseudopapilledema, And Multiple Hemangiomata Macrocephaly, Multiple Lipomas, And Hemangiomata Macrocephaly Pseudopapilledema And Multiple Hemangiomas Ruvalcaba -Myhre-Smith Syndrome Ruvalcaba-Myhre Syndrome Cowden Disease Macrocephaly Pseudopapilledema And Multiple Hemangiomata Cerebellar Granule Cell Hypertrophy And Megalencephaly Cpd6 Lhermitte-Duclos Syndrome Pten Hamartoma Tumor Syndromes Cowden Syndrome, Type 1
Ovarian Cystadenoma	Cystoma Serosum Simplex Simple Cystoma Of Ovary Simple Cystoma Of The Ovary
Fanconi Anemia, Complementation Group A	Fanconi Anemia Fanconi Pancytopenia Fanconi Anemia Complementation Group A FANCA Fa Fanconi Panmyelopathy Fanconi'S Anemia Fanconi Anaemia Fanconi'S Anaemia Fanconi Hypoplastic Anemia Estren-Dameshek Variant Of Fanconi Anemia Estren-Dameshek Variant Of Fanconi Pancytopenia Fanconi Anemia Estren-Dameshek Variant Fanconis Anemia
Aplastic Anemia	Aplastic Anemia, Susceptibility To Anemia Aplastic Idiopathic Aplastic Anemia Secondary Aplastic Anemia Idiopathic Bone Marrow Failure Aplastic Anemia Idiopathic AA Anemia, Aplastic Aplastic Anemia, Idiopathic Erythroid Aplasia Aa - [Aplastic Anaemia] Haematopoietic Aplasia Aleukia Haemorrhagica Anaemia Due To Decreased Red Cell Production Aplasia Bone Marrow Aplastic Bone Marrow Hypoplastic Anaemia Nos Myeloid Bone Marrow Aplasia Pancytopenia Panhaematopenia Hypoproliferative Anaemia Medullary Hypoplasia Red Blood Cells Hypoplastic Anaemia Panmyelophthisis Panhemocytopenia Refractive Hypoproliferative Anaemia Toxic Anaemia Toxic Aplastic Anaemia Aplastic Anaemia Due To Toxic Cause Idiopathic Aplastic Anaemia Nos
Thrombocytopenia	Low Platelet Count Low Platelets Decreased Platelets Platelet Dysfunction Nos
Bile Duct Cystadenoma	Cystadenoma Of The Bile Duct
Familial Adenomatous Polyposis 2	Mutyh-Related Attenuated Familial Adenomatous Polyposis FAP2 Colorectal Adenomatous Polyposis, Autosomal Recessive Adenomas, Multiple Colorectal Mutyh-Associated Polyposis Mutyh-Related Attenuated Familial Polyposis Coli Mutyh-Related Attenuated Fap Adenomas, Multiple Colorectal, Autosomal Recessive Mutyh-Related Afap Adenomas Multiple Colorectal Autosomal Recessive Colorectal Adenomatous Polyposis Autosomal Recessive Adenomatous Polyposis, Familial, Type 2
Hypertrophy Of Breast	Breasts Enlarged Large Breast Hypertrophy Of Breast Nos Hypertrophy Of Male Breast Hypertrophic Breast Excessive Development Of Breast Macromastia Mastoplastia
Xeroderma Pigmentosum, Variant Type	Xeroderma Pigmentosum XPV Xeroderma Pigmentosum Variant Type Xeroderma Pigmentosum With Normal Dna Repair Rates Photosensitivity With Defective Dna Synthesis De Sanctis-Cacchione Syndrome Xp Desanctis-Cacchione Syndrome Xeroderma Pigmentosa Xerodermic Idiocy Xeroderma Pigmentosum Variant Xp - [Xeroderma Pigmentosum] Atrophoderma Pigmentosum
Leukemia, Acute Myeloid	Acute Myeloid Leukemia Leukemia, Acute Myelogenous Acute Myelogenous Leukemia AML Leukemia, Acute Myeloid, Susceptibility To Acute Myeloblastic Leukemia Leukemia, Acute Myeloid, Reduced Survival In, Somatic Acute Myeloid Leukaemia Leukemia, Myelocytic, Acute Therapy Related Acute Myeloid Leukemia And Myelodysplastic Syndrome Secondary Aml Acute Myelocytic Leukemia Leukemia, Myeloid, Acute Acute Myeloid Leukemia, Somatic Leukemia, Acute Myeloid, Somatic Myeloid Leukemia, Acute, M4/M4eo Subtype, Somatic Acute Myeloblastic Leukaemia Acute Myelogenous Leukaemia Aml - Acute Myeloid Leukemia Acute Myeloid Leukemia With Cebpa Somatic Mutations Aml With Cebpa Somatic Mutations Inherited Acute Myeloid Leukemia Familial Aml Inherited Aml Pure Familial Aml Pure Familial Acute Myeloid Leukemia Secondary Acute Myeloid Leukemia Therapy-Related Aml And Myelodysplastic Syndrome Acute Myeloid Leukemia, Secondary Acute Non-Lymphoblastic Leukemia Acute Non-Lymphocytic Leukemia Acute Biphenotypic Leukemia Acute Undifferentiated Leukemia Acute Myeloblastic Leukaemia With Multilineage Dysplasia Acute Myeloid Leukaemia With Multilineage Dysplasia Without Mention Of Remission Acute Myeloid Leukaemia With Myelodysplasia-Related Features
Li-Fraumeni Syndrome	Sarcoma Family Syndrome Of Li And Fraumeni Sbla Syndrome LFS Li-Fraumeni Familiar Cancer Susceptibility Syndrome Sarcoma, Breast, Leukaemia And Adrenal Gland Syndrome Lfs1 Li Fraumeni Syndrome Sarcoma, Breast, Leukemia, And Adrenal Gland Syndrome Lfl Sbla Syndrome Li-Fraumeni-Like Syndrome Li-Fraumeni Syndrome 1
Ataxia-Telangiectasia	Ataxia Telangiectasia Louis-Bar Syndrome AT At1 Ataxia-Telangiectasia Syndrome Ataxia - Telangiectasia Variant Boder-Sedgwick Syndrome Louis Bar Syndrome Cerebello-Oculocutaneous Telangiectasia Immunodeficiency With Ataxia Telangiectasia A-T Ataxia Telangiectasia Syndrome Atm Telangiectasia, Cerebello-Oculocutaneous Ataxia-Telangiectasia Variant
Inherited Cancer-Predisposing Syndrome	Hereditary Cancer-Predisposing Syndrome
Gastric Cancer	Stomach Cancer Stomach Carcinoma Gastric Carcinoma Gastric Cancer, Somatic Gastric Neoplasm Carcinoma Of Stomach Stomach Neoplasms Malignant Neoplasm Of Stomach Gastric Cancer Risk After H. Pylori Infection Cancer Of The Stomach Adult Stomach Cancer Adult Stomach Carcinoma GASC Gastric Cancer Intestinal Gastric Cancers Gastric Carcinomas Cancer, Gastric Stomach Neoplasm Malignant Neoplasm Of Body Of Stomach Malignant Tumor Of Lesser Curve Of Stomach Gastrocarcinoma Of Unspecified Site Leather Bottle Stomach Carcinoma Of Fundus Of Stomach Cancer Of Fundus Of Stomach Primary Malignant Neoplasm Of Body Of Stomach Cancer Of Body Of Stomach Primary Malignant Neoplasm Of Pyloric Antrum Pyloric Antrum Cancer Malignant Tumour Of Stomach
Cerebellar Disease	Cerebellar Diseases Cerebellar Dysfunction Cerebellar Abnormality Cerebellar Disorders
Congenital Heart Defects, Multiple Types, 3	CHTD3 Congenital Heart Defects, Multiple Types, With Cardiac Rhythm And Conduction Disturbances
Nijmegen Breakage Syndrome	Berlin Breakage Syndrome NBS Microcephaly, Normal Intelligence And Immunodeficiency Ataxia-Telangiectasia Variant Ataxia-Telangiectasia Variant V1 Seemanova Syndrome Ii Immunodeficiency-Microcephaly-Chromosomal Instability Syndrome Seemanova Syndrome Type 2 At-V1 Microcephaly With Normal Intelligence, Immunodeficiency, And Lymphoreticular Malignancies Nonsyndromal Microcephaly, Autosomal Recessive, With Normal Intelligence Immunodeficiency, Microcephaly, And Chromosomal Instability Microcephaly-Immunodeficiency-Lymphoreticuloma Syndrome Microcephaly Immunodeficiency Lymphoreticuloma Microcephaly With Normal Intelligence Immunodeficiency And Lymphoreticular Malignancies Nonsyndromal Microcephaly Autosomal Recessive With Normal Intelligence Seemanova Syndrome 2 Ataxia-Telangiectasia Variant 1 Seemanova Syndrome At V1 Ataxia-Telangiectasia, Variant 1 Microcephaly-Immunodeficiency-Lymphoid Malignancy Syndrome V-At Ataxia Telangiectasia Variant V1
Tumor Predisposition Syndrome	TPDS Tumor Predisposition
Lymphoma	Lymphoid Cancer Lymphomas Lymphoid Cancers Lymphoid Neoplasm Lymphoma Nos Nhl - [Non-Hodgkin Lymphoma] Non-Hodgkin Lymphoma Non-Hodgkin Lymphoma, Nos Non-Hodgkin Malignant Lymphoma Nos
Breast Cancer	Breast Carcinoma Breast Cancer, Familial Malignant Neoplasm Of Breast Male Breast Cancer Breast Cancer, Susceptibility To Breast Cancer, Early-Onset Malignant Tumor Of Breast Carcinoma Of Male Breast Breast Cancer, Invasive Ductal Breast Cancer, Protection Against Breast Cancer, Somatic Breast Cancer, Male Breast Cancer, Lobular, Somatic Breast Tumor Mammary Cancer Mammary Tumor Malignant Neoplasm Of Male Breast Mammary Carcinoma Male Breast Carcinoma Familial Cancer Of Breast Invasive Ductal Breast Carcinoma Breast Cancer Susceptibility Breast Cancer, Male, Susceptibility To Breast Cancer, Early-Onset, Susceptibility To Malignant Tumor Of The Breast Mammary Neoplasm Primary Breast Cancer Neoplasm Of Male Breast Carcinoma Of Breast Breast Cancer In Men Familial Breast Cancer Cancer Of Breast BC Breast Cancer Familial Breast Cancer Familial Male Breast Cancer, Familial Male Breast Male Carcinoma Breast Neoplasms Breast Neoplasms, Male Mammary Tumors Mammary Carcinomas Cancer, Breast Cancer, Breast, Susceptibility Invasive Breast Ductal Carcinoma Breast Neoplasm Susceptibility To Breast Cancer Mammary Neoplasms Animal Mammary Neoplasms Primary Malignant Neoplasm Of Breast Infiltrating Ductal Carcinoma Of Breast Infiltrating Duct Carcinoma Of Unspecified Site Infiltrating Ductular Carcinoma Of Unspecified Site Invasive Breast Carcinoma Of No Special Type Microinvasive Carcinoma Of Breast Carcinoma With Apocrine Differentiation
Lynch Syndrome	Hereditary Nonpolyposis Colon Cancer Hereditary Nonpolyposis Colorectal Cancer Hereditary Nonpolyposis Colorectal Carcinoma Hereditary Nonpolyposis Colorectal Neoplasms Familial Nonpolyposis Colon Cancer Hnpcc Coca 1 Hereditary Defective Mismatch Repair Syndrome Hereditary Non-Polyposis Colon Cancer Hereditary Non-Polyposis Colon Cancer Syndrome Hereditary Non-Polyposis Colorectal Cancer Hereditary Non-Polyposis Colorectal Cancer Syndrome Hereditary Nonpolyposis Colon Cancer Syndrome Hereditary Nonpolyposis Colorectal Cancer Syndrome Hereditary Nonpolyposis Colorectal Neoplasm Hnpcc - Hereditary Nonpolyposis Colon Cancer Cancer Family Syndrome Familial Nonpolyposis Colorectal Cancer Colon Cancer, Familial Nonpolyposis Colorectal Neoplasms, Hereditary Nonpolyposis Cancer, Colorectal, Nonpolyposis, Hereditary Colorectal Cancer, Hereditary Nonpolyposis, Type 1
Cowden Syndrome	Cowden Disease Multiple Hamartoma Syndrome Cowden'S Disease Lhermitte-Duclos Disease Cd Cs Mham Dysplastic Gangliocytoma Of Cerebellum Cowden'S Syndrome Hamartoma Syndrome, Multiple
Superficial Urinary Bladder Cancer	Superficial Urinary Bladder Carcinoma Carcinoma Of Urinary Bladder, Superficial
Seckel Syndrome	Microcephalic Primordial Dwarfism Bird-Headed Dwarfism Harper'S Syndrome Virchow-Seckel Dwarfism Nanocephalic Dwarfism Sckl Seckel-Type Dwarfism
Diffuse Gastric And Lobular Breast Cancer Syndrome	Hereditary Diffuse Gastric Cancer HDGC LBC Familial Diffuse Gastric Cancer Fdgc Hereditary Diffuse Gastric Adenocarcinoma Breast Cancer, Lobular Gastric Cancer, Familial Diffuse, And Cleft Lip With Or Without Cleft Palate DGLBC Gastric Cancer, Hereditary Diffuse Gastric Cancer, Familial Diffuse Breast Cancer, Lobular Diffuse Gastric And Lobular Breast Cancer Syndrome With Or Without Cleft Lip And/Or Palate E-Cadherin-Associated Hereditary Gastric Cancer Familial Diffuse Cancer Of Stomach Hereditary Diffuse Cancer Of Stomach Gastric Cancer Familial Diffuse Gastric Cancer Familial Diffuse And Cleft Lip With Or Without Cleft Palate Cancer, Gastric, Hereditary Diffuse
Neuroendocrine Carcinoma	Neuroendocrine Cancer Carcinoma Neuroendocrine Carcinoma, Neuroendocrine
Bilateral Breast Cancer	Bilateral Breast Carcinoma
Premature Menopause	Primary Ovarian Insufficiency Premature Ovarian Failure Hypergonadotropic Hypogonadism Premature Ovarian Insufficiency Menopause - Premature Menopause Praecox Menopause Premature Menopause, Premature Female Hypergonadotropic Hypogonadism Hypergonadotrophic Ovarian Failure Primary Female Hypogonadism Pof - [Premature Ovarian Failure] Ovarian Failure Ovarian Secretion Suppression Ovary Hyposecretion Ovary Secretion Deficiency Premature Menopause Nos
Li-Fraumeni Syndrome 1	Lfs1
Hereditary Ataxia	Sca Spinocerebellar Ataxia Ataxias Hereditary Ataxias, Hereditary
Prostate Cancer	Prostate Carcinoma Prostate Cancer, Familial Prostate Neoplasm Prostate Cancer, Somatic Prostate Cancer, Susceptibility To Prostatic Cancer Prostatic Neoplasms Hereditary Prostate Cancer Prostatic Neoplasm Cancer Of Prostate Carcinoma Of Prostate Familial Prostate Cancer Familial Prostate Carcinoma Malignant Tumor Of Prostate Malignant Neoplasm Of Prostate Prostate Cancer, Familial, Susceptibility To Malignant Tumor Of The Prostate Ngp - New Growth Of Prostate Tumor Of The Prostate Prostate Cancer, Hereditary Cancer Of The Prostate Malignant Neoplasm Of The Prostate Prostatic Carcinoma PC Prca Cancer, Prostate Malignant Prostatic Tumour Malignant Tumour Of Prostate Primary Prostate Cancer Primary Malignant Neoplasm Of Prostate Prostate Gland Cancer
Melanoma, Cutaneous Malignant 1	Familial Melanoma Melanoma, Cutaneous Malignant, Susceptibility To, 1 CMM1 Melanoma, Cutaneous Malignant Cmm Melanoma, Malignant Familial Atypical Mole-Malignant Melanoma Syndrome Fammm Melanoma, Familial Mlm Dysplastic Nevus Syndrome, Hereditary Dns B-K Mole Syndrome Melanoma, Cutaneous Malignant, 1 Malignant Melanoma, Cutaneous Melanoma, Cutaneous, Malignant, Susceptibility To, Type 1 Dysplastic Nevus Syndrome Cutaneous Melanoma Familial Atypical Mole Melanoma Syndrome Hereditary Melanoma
Ovarian Cancer	Ovarian Carcinoma Ovarian Neoplasm Malignant Tumour Of Ovary Epithelial Ovarian Cancer Neoplasm Of Ovary Ovarian Neoplasms Ovarian Cancers Malignant Neoplasm Of Ovary Primary Malignant Neoplasm Of Ovary Ovarian Cancer, Somatic Malignant Ovarian Tumor Ovary Neoplasm Primary Ovarian Cancer Tumor Of The Ovary Cancer Of The Ovary Malignant Neoplasm Of The Ovary Malignant Tumor Of The Ovary Ovarian Malignant Tumor OC Ovarian Carcinomas Cancer, Ovarian Cancer Of Ovary Ovary Cancer Ca Ovary
Acute Promyelocytic Leukemia	Leukemia, Acute Promyelocytic Acute Myeloblastic Leukemia Type 3 Aml M3 APL Leukemia, Acute Promyelocytic, Somatic Aml With T(15 17)(Q22 Q12) (Pml/Raralpha) And Variants Apml Acute Myeloblastic Leukemia 3 Acute Myeloid Leukemia With T(15 17)(Q22 Q12) (Pml/Raralpha) And Variants Acute Myeloblastic Leukaemia Type 3 Acute Myeloid Leukaemia M3 Acute Myeloid Leukemia M3 Acute Promyelocytic Leukaemia M3 Anll Myeloid Leukemia, Acute, M3 Leukemia Promyelocytic Acute Leukemia, Promyelocytic, Acute Leukemia, Acute, Promyelocytic
Sarcoma	Connective And Soft Tissue Neoplasm Tumor Of Soft Tissue And Skeleton Sarcomas Sarcoma - Category
Wilms Tumor 1	Nephroblastoma Wilms Tumor WT1 Wilms' Tumor Bilateral Wilms Tumor Wilms Tumor, Type 1 Wilms Tumor, Somatic Adult Nephroblastoma Wt1 Disorder Renal Embryonic Tumor Adult Kidney Wilms Tumor Childhood Kidney Wilms Tumor Nonanaplastic Kidney Wilms Tumor
Rhabdomyosarcoma
Diamond-Blackfan Anemia 11	DBA11 Rpl26-Related Diamond-Blackfan Anemia Anemia, Diamond-Blackfan, Type 11
Telangiectasis	Telangiectasia
Hereditary Breast Cancer	Familial Breast Cancer Familial Breast Carcinoma Hereditary Breast Carcinoma
Autosomal Genetic Disease	Autosomal Hereditary Disorder
Colitis
Small Cell Carcinoma	Small Cell Carcinoma, Intermediate Cell Intermediate Cell Small Cell Carcinoma Small Cell Carcinoma - Intermediate Cell Small Cell Carcinoma Of Lung Carcinoma, Small Cell
Leiomyosarcoma	Leiomyosarcomas
Cervical Adenoma Malignum	Cervical Mucinous Adenocarcinoma, Minimal Deviation Variant
Myelodysplastic Syndrome	Myelodysplastic Syndromes Myelodysplasia MDS Myelodysplastic Syndrome Included Myelodysplastic Syndrome, Susceptibility To, Included Myelodysplastic Syndrome, Somatic Myelodysplastic Syndrome, Susceptibility To
Colorectal Cancer	Colon Cancer Colorectal Carcinoma Colon Carcinoma Colorectal Cancer, Susceptibility To Carcinoma Of Colon CRC Colorectal Cancer With Chromosomal Instability, Somatic Colon Cancer, Somatic Colon Cancer, Susceptibility To Colonic Neoplasms Colorectal Neoplasms Colorectal Cancer, Somatic Colon Cancer, Advanced, Somatic Colonic Carcinoma Colorectal Carcinomas Colon Cancers Colorectal Cancers Cancer, Colorectal, Somatic Cancer, Colon Cancer, Colorectal, Susceptibility To Colorectal Neoplasm Colonic Neoplasm Malignant Tumor Of Colon
Fallopian Tube Carcinoma	Fallopian Tube Cancer Cancer Of The Fallopian Tube Carcinoma Of Fallopian Tube Neoplasm Of Fallopian Tube Fallopian Tube Neoplasms Fallopian Tube Ca Fallopian Tube Neoplasm Malignant Neoplasm Of Uterine Tube Malignant Tumor Of Fallopian Tube Malignant Tumour Of Fallopian Tube Tumor Of The Fallopian Tube Tumor, Fallopian Tube, Malignant Malignant Tumor Of Fallopian Tubes Cancer Of Fallopian Tubes Malignant Tubal Tumor Tubal Cancer Malignant Neoplasm Of Fallopian Tube Primary Malignant Neoplasm Of Fallopian Tube Cancer Of The Oviduct
Li-Fraumeni Syndrome 2	LFS2 Li-Fraumeni Syndrome, Type 2 Li-Fraumeni Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-173147	CDK2-IN-42	Inhibitor	/	Unkown
HY-RS02619	CHEK2 Human Pre-designed siRNA Set A		/	Unkown
HY-RS02620	Chek2 Mouse Pre-designed siRNA Set A		/	Unkown
HY-RS02621	Chek2 Rat Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	CHEK2	VGNC	VGNC:60851
Rattus norvegicus	CHEK2	RGD	RGD:621543
Macaca mulatta	CHEK2	VGNC	VGNC:70958
Bos taurus	CHEK2	VGNC	VGNC:27286
Mus musculus	CHEK2	MGD	MGI:1355321
Canis familiaris	CHEK2	VGNC	VGNC:39209
Others	CHEK2	NCBI