Aco1 - aconitase 1 Gene

Also Known as Irp1; Aco-1; Irebp

Species: Mus musculus

Gene Type: protein coding
Gene ID: 11428

Summary

This gene encodes a member of the aconitase/IPM isomerase protein family. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. Depending on iron levels in the cytosol, the encoded protein can function as either an aconitase enzyme or as an mRNA binding protein. When cellular iron levels are high, the encoded protein functions as an aconitase, an essential enzyme in the TCA cycle that catalyzes the conversion of citrate to isocitrate. When cellular iron levels are low, the encoded protein regulates iron uptake and utilization by binding to iron-responsive elements in the untranslated regions of mRNAs for genes involved in iron metabolism. Disruption of this gene is associated with pulmonary hypertension and polycythemia. [provided by RefSeq, Jan 2014]

Aco1 Products (1)

mRNA Protein Name
NM_007386.2 NP_031412.2 cytoplasmic aconitate hydratase

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables aconitate hydratase activity IDA
IDA: Inferred from direct assay
14726953 MGI
enables iron-responsive element binding IDA
IDA: Inferred from direct assay
8262972 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within intestinal absorption IGI
IGI: Inferred from genetic interaction
18177727 MGI
acts upstream of or within intracellular iron ion homeostasis IGI
IGI: Inferred from genetic interaction
14726953 MGI
acts upstream of or within intracellular iron ion homeostasis IMP
IMP: Inferred from mutant phenotype
14726953 MGI
acts upstream of or within post-embryonic development IGI
IGI: Inferred from genetic interaction
18177727 MGI
acts upstream of or within regulation of gene expression IGI
IGI: Inferred from genetic interaction
18177727 MGI
acts upstream of or within regulation of translation IMP
IMP: Inferred from mutant phenotype
14726953 MGI
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
8262972 MGI
located in cytosol IDA
IDA: Inferred from direct assay
14726953 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

cytoplasmic aconitate hydratase

  • IRE-BP 1

  • citrate hydro-lyase

  • cytoplasmic aconitase

  • iron regulatory protein 1

  • iron-responsive element-binding protein 1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS00170 ACO1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18459 Aco1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24940 Aco1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Aco1 NCBI NCBI:48