Acr - acrosin prepropeptide Gene

Species: Mus musculus

Gene Type: protein coding
Gene ID: 11434

Summary

Enables peptidase activity. Involved in single fertilization. Acts upstream of or within binding activity of sperm to zona pellucida and penetration of zona pellucida. Located in acrosomal vesicle. Is expressed in testis. Orthologous to human ACR (acrosin). [provided by Alliance of Genome Resources, Apr 2022]

Acr Products (7)

mRNA Protein Name
NM_001205049.2 NP_001191978.1 acrosin isoform 2 precursor
NM_001277245.2 NP_001264174.1 acrosin isoform 3
NM_001277246.2 NP_001264175.1 acrosin isoform 3
NM_001277247.2 NP_001264176.1 acrosin isoform 4 precursor
NM_001411168.1 NP_001398097.1 acrosin isoform 5 precursor
NM_001411169.1 NP_001398098.1 acrosin isoform 3
NM_013455.4 NP_038483.1 acrosin isoform 1 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables peptidase activity IMP
IMP: Inferred from mutant phenotype
7989357 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
11739644 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within binding of sperm to zona pellucida IGI
IGI: Inferred from genetic interaction
15685642 MGI
acts upstream of or within penetration of zona pellucida IGI
IGI: Inferred from genetic interaction
15051954 MGI
acts upstream of or within penetration of zona pellucida IMP
IMP: Inferred from mutant phenotype
7989357 MGI
involved in single fertilization IMP
IMP: Inferred from mutant phenotype
15685642 MGI
Cellular Component GO Annotation Evidence References Source
located in acrosomal vesicle IDA
IDA: Inferred from direct assay
7798216 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

acrosin

  • preproacrosin

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Phase
HY-111210 Pridopidine hydrochloride Antagonist / Phase 3
HY-19845 Ordopidine Antagonist / Phase 1
HY-19845A Ordopidine hydrochloride Modulator / Phase 1

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-10684 Pridopidine Antagonist 99.85% Yes
HY-129126 NC9 Inhibitor 99.98% Unkown
HY-RS00193 ACR Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17573 Acr Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24033 Acr Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Acr NCBI NCBI:49