ACR - acrosin Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 49

About ACR

Cytogenetic location: 22q13.33 Genomic coordinates (GRCh38): 22:50,738,204-50,745,339 (from NCBI)

This gene has 4 transcripts (splice variants), 1 gene allele and 105 orthologues. Restricted expression toward testis (RPKM 44.8).

Summary

Acrosin is the major proteinase present in the acrosome of mature spermatozoa. It is a typical serine proteinase with trypsin-like specificity. It is stored in the acrosome in its precursor form, proacrosin. The active enzyme functions in the lysis of the zona pellucida, thus facilitating penetration of the sperm through the innermost glycoprotein layers of the ovum. The mRNA for proacrosin is synthesized only in the postmeiotic stages of spermatogenesis. In humans proacrosin first appears in the haploid spermatids. [provided by RefSeq, Jul 2008]

ACR Products (1)

mRNA Protein Name
NM_001097.3 NP_001088.2 acrosin precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables D-mannose binding IDA
IDA: Inferred from direct assay
15950652 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
7521127 GOA
enables serine-type endopeptidase activity IDA
IDA: Inferred from direct assay
6802470 GOA
Biological Process GO Annotation Evidence References Source
involved in acrosome reaction IMP
IMP: Inferred from mutant phenotype
2550339 GOA
involved in activation of adenylate cyclase activity IDA
IDA: Inferred from direct assay
3880736 GOA
Cellular Component GO Annotation Evidence References Source
part of protein-containing complex IDA
IDA: Inferred from direct assay
7521127 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ACR Protein Structure

Trypsin

Trypsin: Trypsin (43 - 285)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 421 a.a.
Protein Preferred Names Protein Names

acrosin

  • acrosin light and heavy chain prepropeptide

Related Diseases

Diseases Alias
Varicocele

  • Scrotal Varices

  • Varicoceles

  • Varicocele Of Scrotum

  • Scrotal Varicocele
Spermatogenic Failure 6

  • Globozoospermia

  • SPGF6

  • Round-Headed Spermatozoa

  • Acrosome Malformation Of Spermatozoa

  • Spermatogenic Failure 9

  • Spermatozoa, Round-Headed

  • Globozoospermia, Complete

  • Globozoospermia, Total

  • Mae Infertility Due To Round-Headed Spermatozoa

  • Male Infertility Due To Globozoospermia

  • Male Infertility Due To Round-Headed Spermatozoa

  • Round-Headed Sperm Syndrome

  • Spgf9

  • Teratozoospermia
Chronic Congestive Splenomegaly
Pulmonary Coin Lesion

  • Coin Lesion Of Lung

  • Solitary Pulmonary Nodule

  • Coin Lesion Lung
Rectum Lymphoma

  • Lymphoma Of Rectum
Supine Hypotensive Syndrome

  • Maternal Hypotension Syndrome

  • Antepartum Maternal Hypotension Syndrome

  • Postpartum Maternal Hypotension Syndrome

  • Maternal Hypotension Syndrome, Antepartum Condition Or Complication

  • Maternal Hypotension Syndrome, Postpartum Condition Or Complication

  • Maternal Hypotension Syndrome, Unspecified Trimester
Nutmeg Liver

  • Chronic Passive Congestion Of Liver
Male Infertility

  • Infertility, Male

  • Infertility Male

  • Male Sterility

  • Absolute Infertility
Infertility
Waterhouse-Friderichsen Syndrome

  • Fatal Pneumococcal Waterhouse-Friderichsen Syndrome

  • Meningococcal Hemorrhagic Adrenalitis

  • Waterhouse-Friderichsen Syndrome, Meningococcal

  • Meningococcal Haemorrhagic Adrenalitis

  • Meningococcal Adrenal Syndrome

  • Acute Adrenal Insufficiency With Meningococcal Septicaemia

  • Adrenal Haemorrhage Syndrome

  • Waterhouse-Friderichsen Disease

  • Meningococcal Waterhouse-Friderichsen Syndrome

  • Haemorrhagic Meningococcal Adrenitis
Mucocele Of Salivary Gland

  • Ranula

  • Salivary Cyst

  • Salivary Gland Mucocele

  • Mucous Retention Cyst Of Salivary Gland

  • Retention Cyst Of Salivary Gland

  • Sialocele

  • Cyst Of Salivary Gland Or Duct

  • Extravasation Cyst Of Salivary Gland
Colonic Lymphangioma

  • Lymphangioma Of Colon

  • Colon Lymphangioma
Sialolithiasis

  • Sialolith

  • Stone Of Salivary Gland Or Duct

  • Salivary Gland Calculi

  • Salivary Gland Stone

  • Calculus Of Salivary Gland Or Duct

  • Calculus Of Salivary Gland

  • Salivary Calculus

  • Salivary Gland Calculus

  • Salivary Stone

  • Salivary Duct Calculi

  • Sialodocholithiasis
Parasitic Ichthyosporea Infectious Disease
Rhinosporidiosis

  • Infection By Rhinosporidium Seeberi

  • Rhinosporosis
Spermatogenic Failure 9

  • Male Infertility Due To Globozoospermia

  • SPGF9

  • Male Infertility Due To Round-Headed Spermatozoa

  • Globozoospermia, Complete

  • Globozoospermia, Total

  • Globozoospermia

  • Globozoospermia Syndrome

  • Round-Headed Sperm Syndrome

  • Globozoospermia Complete

  • Globozoospermia Total
Pelvic Varices

  • Varix Of Pelvis

  • Pelvic Varicose Vein
Acquired Hemangioma
Mucinous Adenofibroma
Schizophrenia 14

  • Sczd14

  • Schizophrenia, Susceptibility To, 14

  • Schizophrenia Susceptibility Locus, Chromosome 2q32-Related
Urinary Bladder Small Cell Neuroendocrine Carcinoma

  • Small Cell Neuroendocrine Carcinoma Of The Urinary Bladder

  • Small Cell/Neuroendocrine Carcinoma Of Urinary Bladder
Lemierre'S Syndrome

  • Lemierre Syndrome

  • Lemierre Postanginal Sepsis

  • Necrobacillosis

  • Postanginal Sepsis Secondary To Orophyngeal Infection

  • Septic Phlebitis Of The Internal Jugular Vein

  • Fusobacterium Infections

  • Acute Sore Throat

  • Human Necrobacillosis

  • Postanginal Sepsis

  • Oropharyngeal Infection Leading To Secondary Septic Thrombophlebitis Of The Internal Jugular Vein
Chronic Dacryocystitis
Oligoasthenoteratozoospermia

  • Oat

  • Oligoasthenoteratospermia
Spermatogenic Failure

  • Azoospermia

  • Spgf

  • Spermatogenic Failure, Susceptibility To

  • Absent Sperm

  • Aspermatogenesis

  • Infertility Due To Azoospermia

  • Hypospermatogenesis

  • Azoospermatism
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Phase
HY-111210 Pridopidine hydrochloride Antagonist / Phase 3
HY-19845 Ordopidine Antagonist / Phase 1
HY-19845A Ordopidine hydrochloride Modulator / Phase 1

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-10684 Pridopidine Antagonist 99.85% Yes
HY-129126 NC9 Inhibitor 99.98% Unkown
HY-RS00193 ACR Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17573 Acr Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24033 Acr Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta ACR VGNC VGNC:69386
Felis catus ACR VGNC VGNC:59529
Rattus norvegicus ACR RGD RGD:2024
Bos taurus ACR VGNC VGNC:25557
Mus musculus ACR MGD MGI:87884
Canis familiaris ACR VGNC VGNC:37526
Others ACR NCBI