Itga6 - integrin subunit alpha 6 Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 114517

Summary

Enables laminin binding activity. Involved in cell-cell adhesion; cellular response to organic cyclic compound; and positive regulation of cell-substrate adhesion. Located in adherens junction and filopodium. Part of Integrin alpha6-beta4 complex. Human ortholog(s) of this gene implicated in junctional epidermolysis bullosa and junctional epidermolysis bullosa with pyloric atresia. Orthologous to human ITGA6 (Integrin subunit alpha 6). [provided by Alliance of Genome Resources, Apr 2022]

Itga6 Products (1)

mRNA Protein Name
NM_053725.2 NP_446177.2 integrin alpha-6 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables laminin binding IPI
IPI: Inferred from physical interaction
16608848 RGD
enables protein-containing complex binding IDA
IDA: Inferred from direct assay
13130099 RGD
Biological Process GO Annotation Evidence References Source
involved in cell-cell adhesion IMP
IMP: Inferred from mutant phenotype
16557522 RGD
involved in cellular response to organic cyclic compound IEP
IEP: Inferred from expression pattern
13130099 RGD
involved in positive regulation of cell-substrate adhesion IMP
IMP: Inferred from mutant phenotype
13130099 RGD
Cellular Component GO Annotation Evidence References Source
located in adherens junction IDA
IDA: Inferred from direct assay
16608848 RGD
located in filopodium IDA
IDA: Inferred from direct assay
13130099 RGD
part of integrin alpha6-beta4 complex IDA
IDA: Inferred from direct assay
13130099 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

integrin alpha-6

  • integrin, alpha 6

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-132974 Aminoflavone / Phase 2

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS06953 ITGA6 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18523 Itga6 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25005 Itga6 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Itga6 NCBI NCBI:3655