Becn1 - beclin 1 Gene

Rattus norvegicus

Also known as Beclin1

Gene ID: 114558 | Gene type: protein coding

About Becn1

Primary_assembly 10: 86,231,388-86,246,742 reverse strand.mRatBN7.2:CM026983.1

This gene has 3 transcripts (splice variants), 214 orthologues, 1 paralogue and is associated with 63 phenotypes. Biased expression in Kidney (RPKM 276.8), Thymus (RPKM 266.7) and 9 other tissues.

Summary

Enables ubiquitin protein ligase binding activity. Involved in several processes, including cellular response to metal ion; regulation of apoptotic process; and regulation of vacuole organization. Located in cytoplasm; dendrite; and nucleus. Colocalizes with trans-Golgi network. Used to study brain ischemia and middle cerebral artery infarction. Biomarker of several diseases, including Barrett's esophagus; acute necrotizing pancreatitis; artery disease (multiple); brain disease (multiple); and neuropathy (multiple). Human ortholog(s) of this gene implicated in Machado-Joseph disease. Orthologous to human BECN1 (beclin 1). [provided by Alliance of Genome Resources, Apr 2022]

Becn1 Products(2)

mRNA	Protein	Name
NM_053739.2	NP_446191.1	beclin-1
NM_001034117.1	NP_001029289.1	beclin-1

Becn1 Protein Structure

BH3

APG6_N

APG6

0
100
200
300
400
448 a.a.

Protein Preferred Names

Protein Names

beclin-1

beclin 1 (coiled-coil, myosin-like BCL2-interacting protein)	beclin 1, autophagy related
coiled-coil myosin-like BCL2-interacting protein

Related Agents

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-137506	XST-14		99.69%	Unkown
HY-149954	SARS-CoV-2-IN-39	Inhibitor	99.51%	Unkown
HY-RS01463	BECN1 Human Pre-designed siRNA Set A		/	Unkown
HY-RS01464	Becn1 Mouse Pre-designed siRNA Set A		/	Unkown
HY-RS01465	Becn1 Rat Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Becn1	NCBI	NCBI:8678

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