Becn1 - beclin 1 Gene

Also Known as Beclin1

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 114558

About Becn1

Primary_assembly 10: 86,231,388-86,246,742 reverse strand.mRatBN7.2:CM026983.1

This gene has 3 transcripts (splice variants), 214 orthologues, 1 paralogue and is associated with 63 phenotypes. Biased expression in Kidney (RPKM 276.8), Thymus (RPKM 266.7) and 9 other tissues.

Summary

Enables ubiquitin protein Ligase binding activity. Involved in several processes, including cellular response to metal ion; regulation of apoptotic process; and regulation of vacuole organization. Located in cytoplasm; dendrite; and nucleus. Colocalizes with trans-Golgi network. Used to study brain ischemia and middle cerebral artery infarction. Biomarker of several diseases, including Barrett's esophagus; acute necrotizing pancreatitis; artery disease (multiple); brain disease (multiple); and neuropathy (multiple). Human ortholog(s) of this gene implicated in Machado-Joseph disease. Orthologous to human BECN1 (beclin 1). [provided by Alliance of Genome Resources, Apr 2022]

Becn1 Products (4)

mRNA Protein Name
NM_053739.2 NP_446191.1 beclin-1
NM_001034117.1 NP_001029289.1 beclin-1
NM_001034117.1 NP_001029289.1 beclin-1
NM_053739.2 NP_446191.1 beclin-1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
25117440 RGD
enables ubiquitin protein ligase binding IPI
IPI: Inferred from physical interaction
24879156 RGD
Biological Process GO Annotation Evidence References Source
involved in JNK cascade IMP
IMP: Inferred from mutant phenotype
27769861 RGD
involved in SMAD protein signal transduction IDA
IDA: Inferred from direct assay
27769861 RGD
involved in autophagosome assembly IMP
IMP: Inferred from mutant phenotype
16420522 RGD
involved in autophagy IMP
IMP: Inferred from mutant phenotype
16697404 RGD
involved in cellular response to aluminum ion IEP
IEP: Inferred from expression pattern
22138567 RGD
involved in cellular response to amino acid starvation IEP
IEP: Inferred from expression pattern
22835012 RGD
involved in cellular response to copper ion IEP
IEP: Inferred from expression pattern
22540380 RGD
involved in cellular response to epidermal growth factor stimulus IEP
IEP: Inferred from expression pattern
20539009 RGD
involved in cellular response to hydrogen peroxide IEP
IEP: Inferred from expression pattern
23314838 RGD
involved in cellular response to oxygen-glucose deprivation IEP
IEP: Inferred from expression pattern
27769861 RGD
involved in negative regulation of apoptotic process IMP
IMP: Inferred from mutant phenotype
20075199 RGD
involved in negative regulation of lysosome organization IMP
IMP: Inferred from mutant phenotype
25561470 RGD
involved in p38MAPK cascade IMP
IMP: Inferred from mutant phenotype
27769861 RGD
involved in positive regulation of autophagosome assembly IMP
IMP: Inferred from mutant phenotype
25561470 RGD
involved in positive regulation of autophagy IMP
IMP: Inferred from mutant phenotype
21490676 RGD
involved in positive regulation of intrinsic apoptotic signaling pathway IMP
IMP: Inferred from mutant phenotype
27031958 RGD
involved in positive regulation of stress granule assembly IMP
IMP: Inferred from mutant phenotype
30404558 RGD
involved in response to hypoxia IEP
IEP: Inferred from expression pattern
22449108 RGD
involved in response to iron(II) ion IEP
IEP: Inferred from expression pattern
23187302 RGD
involved in response to lead ion IEP
IEP: Inferred from expression pattern
22927075 RGD
involved in response to nutrient levels IEP
IEP: Inferred from expression pattern
17665967 RGD
involved in response to vitamin E IEP
IEP: Inferred from expression pattern
19138675 RGD
involved in response to xenobiotic stimulus IEP
IEP: Inferred from expression pattern
22521819 RGD
Cellular Component GO Annotation Evidence References Source
located in dendrite IDA
IDA: Inferred from direct assay
21490676 RGD
located in trans-Golgi network IDA
IDA: Inferred from direct assay
11306555 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Becn1 Protein Structure

BH3

BH3: pfam15285 (104 - 126)

APG6_N

APG6_N: pfam17675 (132 - 258)

APG6

APG6: pfam04111 (264 - 442)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 448 a.a.
Protein Preferred Names Protein Names

beclin-1

  • beclin 1 (coiled-coil, myosin-like BCL2-interacting protein)

  • beclin 1, autophagy related

  • coiled-coil myosin-like BCL2-interacting protein

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-137506 XST-14 99.26% Unkown
HY-N1956 Rubiadin-1-methyl ether Inhibitor 98.57% Unkown
HY-149954 SARS-CoV-2-IN-39 Inhibitor 99.79% Unkown
HY-RS01463 BECN1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS01464 Becn1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS01465 Becn1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Becn1 NCBI NCBI:8678