Adam2 - a disintegrin and metallopeptidase domain 2 Gene

Also Known as Ftnb; Ph30-beta

Species: Mus musculus

Gene Type: protein coding
Gene ID: 11495

Summary

This gene encodes a member of a disintegrin and metalloprotease (ADAM) family of endoproteases that play important roles in various biological processes including cell signaling, adhesion and migration. This gene is predominantly expressed in the epididymis, where the encoded preproprotein undergoes proteolytic processing to generate a mature, functional protein. Male mice lacking the encoded protein are infertile and exhibit multiple defects in reproduction. [provided by RefSeq, May 2016]

Adam2 Products (1)

mRNA Protein Name
NM_009618.3 NP_033748.2 disintegrin and metalloproteinase domain-containing protein 2 preproprotein

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
15194697 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within adult behavior IMP
IMP: Inferred from mutant phenotype
16504143 MGI
acts upstream of or within cell adhesion IGI
IGI: Inferred from genetic interaction
21060781 MGI
acts upstream of or within gene expression IMP
IMP: Inferred from mutant phenotype
16407499 MGI
acts upstream of or within positive regulation of gene expression IMP
IMP: Inferred from mutant phenotype
19129510 MGI
acts upstream of or within visual learning IMP
IMP: Inferred from mutant phenotype
16504143 MGI
Cellular Component GO Annotation Evidence References Source
is active in cell surface IDA
IDA: Inferred from direct assay
16407499 MGI
located in cell surface IDA
IDA: Inferred from direct assay
21273369 MGI
part of protein-containing complex IDA
IDA: Inferred from direct assay
19129510 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

disintegrin and metalloproteinase domain-containing protein 2

  • a disintegrin and metalloprotease domain 2 (fertilin beta)

  • fertilin subunit beta

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS00276 ADAM2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22377 Adam2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28901 Adam2 Rat Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Adam2 NCBI NCBI:2515