Adam8 - a disintegrin and metallopeptidase domain 8 Gene

Also Known as MS2; CD156; ADAM 8; CD156a; E430039A18Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 11501

About Adam8

Chromosome 7: 139,558,845-139,572,475 reverse strand.GRCm39:CM001000.3

This gene has 8 transcripts (splice variants), 245 orthologues, 35 paralogues and is associated with 8 phenotypes. Broad expression in ovary adult (RPKM 21.), thymus adult (RPKM 6.6) and 19 other tissues.

Summary

This gene encodes a member of the Adam family of proteins that contain the disintegrin and metalloprotease domains. The encoded protein is localized to the cell surface, where it is involved in the remodeling of extracellular matrix and cell migration. Mice lacking the encoded protein display persistent inflammation upon treatment with allergens. Alternative splicing of this gene results in multiple variants. [provided by RefSeq, Mar 2015]

Adam8 Products (2)

mRNA Protein Name
NM_001291066.2 NP_001277995.1 disintegrin and metalloproteinase domain-containing protein 8 isoform 2 precursor
NM_007403.3 NP_031429.1 disintegrin and metalloproteinase domain-containing protein 8 isoform 1 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables calcium ion binding IDA
IDA: Inferred from direct assay
12372841 MGI
enables cell adhesion molecule binding IPI
IPI: Inferred from physical interaction
12135759 MGI
enables metallopeptidase activity IDA
IDA: Inferred from direct assay
12135759 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
12135759 MGI
enables zinc ion binding IDA
IDA: Inferred from direct assay
12135759 MGI
Biological Process GO Annotation Evidence References Source
involved in angiogenesis IDA
IDA: Inferred from direct assay
19003792 MGI
involved in canonical NF-kappaB signal transduction IDA
IDA: Inferred from direct assay
20683884 MGI
involved in cell morphogenesis IMP
IMP: Inferred from mutant phenotype
11341326 MGI
acts upstream of or within cell-cell adhesion IDA
IDA: Inferred from direct assay
12372841 MGI
involved in leukocyte migration involved in inflammatory response IMP
IMP: Inferred from mutant phenotype
20194813 MGI
involved in lymphocyte chemotaxis IDA
IDA: Inferred from direct assay
20856819 MGI
involved in negative regulation of neuron apoptotic process IDA
IDA: Inferred from direct assay
14761956 MGI
involved in positive regulation of MAPK cascade IDA
IDA: Inferred from direct assay
20683884 MGI
involved in positive regulation of T cell differentiation in thymus IDA
IDA: Inferred from direct assay
20856819 MGI
involved in positive regulation of T cell migration IMP
IMP: Inferred from mutant phenotype
20194813 MGI
involved in positive regulation of acute inflammatory response IMP
IMP: Inferred from mutant phenotype
21268008 MGI
involved in positive regulation of bone resorption IDA
IDA: Inferred from direct assay
11341326 MGI
involved in positive regulation of bone resorption IMP
IMP: Inferred from mutant phenotype
20683884 MGI
involved in positive regulation of cell adhesion IDA
IDA: Inferred from direct assay
12372841 MGI
involved in positive regulation of cellular extravasation IMP
IMP: Inferred from mutant phenotype
20194813 MGI
involved in positive regulation of eosinophil migration IMP
IMP: Inferred from mutant phenotype
20194813 MGI
involved in positive regulation of epithelial to mesenchymal transition IMP
IMP: Inferred from mutant phenotype
34615811 MGI
involved in positive regulation of fibronectin-dependent thymocyte migration IMP
IMP: Inferred from mutant phenotype
20856819 MGI
involved in positive regulation of inflammatory response IDA
IDA: Inferred from direct assay
19397475 MGI
involved in positive regulation of innate immune response IDA
IDA: Inferred from direct assay
20683884 MGI
involved in positive regulation of membrane protein ectodomain proteolysis IDA
IDA: Inferred from direct assay
14761956 MGI
involved in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IDA
IDA: Inferred from direct assay
20683884 MGI
involved in positive regulation of thymocyte apoptotic process IMP
IMP: Inferred from mutant phenotype
20856819 MGI
involved in positive regulation of tumor necrosis factor (ligand) superfamily member 11 production IMP
IMP: Inferred from mutant phenotype
20683884 MGI
Cellular Component GO Annotation Evidence References Source
part of alpha9-beta1 integrin-ADAM8 complex IDA
IDA: Inferred from direct assay
16995821 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
12372841 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Adam8 Protein Structure

Pep_M12B_propep

Pep_M12B_propep: pfam01562 (26 - 150)

Reprolysin

Reprolysin: pfam01421 (194 - 393)

DISIN

DISIN: smart00050 (410 - 484)

ACR

ACR: smart00608 (486 - 605)

PHA03247

PHA03247: cl33720 (693 - 805)

  • 0
  • 200
  • 400
  • 600
  • 825 a.a.
Protein Preferred Names Protein Names

disintegrin and metalloproteinase domain-containing protein 8

  • a disintegrin and metalloprotease domain 8

  • cell surface antigen MS2

  • macrophage cysteine-rich glycoprotein

Recombinant Adam8 Proteins

Cat. No. Product Name Accession Purity
HY-P77558 ADAM8 Protein, Mouse (HEK293, His) Q05910 (P17-S658) ≥ 95%, as determined by Bis-Tris PAGE.

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-120852 JG26 Inhibitor 98.14% Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Adam8 NCBI NCBI:101