Adam8 - a disintegrin and metallopeptidase domain 8 Gene

Mus musculus

Also known as MS2; CD156; ADAM 8; CD156a; E430039A18Rik

Gene ID: 11501 | Gene type: protein coding

About Adam8

Chromosome 7: 139,558,845-139,572,475 reverse strand.GRCm39:CM001000.3

This gene has 8 transcripts (splice variants), 245 orthologues, 35 paralogues and is associated with 8 phenotypes. Broad expression in ovary adult (RPKM 21.), thymus adult (RPKM 6.6) and 19 other tissues.

Summary

This gene encodes a member of the Adam family of proteins that contain the disintegrin and metalloprotease domains. The encoded protein is localized to the cell surface, where it is involved in the remodeling of extracellular matrix and cell migration. Mice lacking the encoded protein display persistent inflammation upon treatment with allergens. Alternative splicing of this gene results in multiple variants. [provided by RefSeq, Mar 2015]

Adam8 Products(2)

mRNA	Protein	Name
NM_001291066.2	NP_001277995.1	disintegrin and metalloproteinase domain-containing protein 8 isoform 2 precursor
NM_007403.3	NP_031429.1	disintegrin and metalloproteinase domain-containing protein 8 isoform 1 precursor

Adam8 Protein Structure

Pep_M12B_propep

Reprolysin

DISIN

ACR

PHA03247

0
200
400
600
825 a.a.

Protein Preferred Names

Protein Names

disintegrin and metalloproteinase domain-containing protein 8

a disintegrin and metalloprotease domain 8	cell surface antigen MS2
macrophage cysteine-rich glycoprotein

Recombinant Adam8 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P77558	ADAM8 Protein, Mouse (HEK293, His)	Q05910 (P17-S658)	≥95%

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-120852	JG26	Inhibitor	98.01%	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Adam8	NCBI	NCBI:101
Macaca mulatta	Adam8	NCBI	NCBI:100428452