ADAM8 - ADAM metallopeptidase domain 8 Gene

Homo sapiens

Also known as MS2; CD156; CD156a

Gene ID: 101 | Gene type: protein coding

About ADAM8

Cytogenetic location: 10q26.3 Genomic coordinates (GRCh38): 10:133,262,423-133,276,868 (from NCBI)

This gene has 11 transcripts (splice variants), 245 orthologues and 20 paralogues. Biased expression in bone marrow (RPKM 22.3), spleen (RPKM 13.4) and 12 other tissues.

Summary

This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The protein encoded by this gene may be involved in cell adhesion during neurodegeneration, and it is thought to be a target for allergic respiratory diseases, including asthma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2009]

ADAM8 Products(8)

mRNA	Protein	Name
XR_007061938.1
XM_047424425.1	XP_047280381.1	disintegrin and metalloproteinase domain-containing protein 8 isoform X3
XM_047424423.1	XP_047280379.1	disintegrin and metalloproteinase domain-containing protein 8 isoform X1
NM_001164489.2	NP_001157961.1	disintegrin and metalloproteinase domain-containing protein 8 isoform 2 precursor
NM_001164490.2	NP_001157962.1	disintegrin and metalloproteinase domain-containing protein 8 isoform 3
NM_001109.5	NP_001100.3	disintegrin and metalloproteinase domain-containing protein 8 isoform 1 precursor
XM_047424424.1	XP_047280380.1	disintegrin and metalloproteinase domain-containing protein 8 isoform X2
XM_047424426.1	XP_047280382.1	disintegrin and metalloproteinase domain-containing protein 8 isoform X4

ADAM8 Protein Structure

Pep_M12B_propep

Reprolysin

Disintegrin

ADAM_CR

0
200
400
600
824 a.a.

Protein Preferred Names

Protein Names

disintegrin and metalloproteinase domain-containing protein 8

a disintegrin and metalloproteinase domain 8	cell surface antigen MS2
human leukocyte differentiation antigen

Recombinant ADAM8 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P75532	ADAM8 Protein, Human (HEK293, His)	AAI15405.1 (I17-P655)	≥95%
HY-P77866	ADAM8 Protein, Human (639a.a, HEK293, His)	P78325 (I17-P655)	≥95%

Related Diseases

Diseases

Alias

Asthma

Chronic Obstructive Asthma	Asthma, Diminished Response To Antileukotriene Treatment In
Bronchial Hyperreactivity	Asthma, Susceptibility To
Asthma, Bronchial	Asthma, Protection Against
Asthma, Nocturnal, Susceptibility To	Nocturnal Asthma
Asthma-Related Traits	Asthma-Related Traits, Susceptibility To
Asthma, Nocturnal	Chronic Obstructive Asthma With Acute Exacerbation
Chronic Obstructive Asthma With Status Asthmaticus	Exercise Induced Asthma
Exercise-Induced Asthma	Bronchial Asthma
Asthma, Exercise-Induced	Idiosyncratic Asthma
Unspecified Asthma With Acute Exacerbation	Asthma, Unspecified, With Stated Status Asthmaticus
Status Asthmaticus Nos	Acute Severe Asthma
Acute Severe Bronchial Asthma	Status Asthma
Status Post Asthmaticus

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-120852	JG26	Inhibitor	98.01%	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	ADAM8	VGNC	VGNC:69494
Mus musculus	ADAM8	MGD	MGI:107825
Canis familiaris	ADAM8	VGNC	VGNC:37587
Bos taurus	ADAM8	VGNC	VGNC:25612
Felis catus	ADAM8	VGNC	VGNC:59584
Rattus norvegicus	ADAM8	RGD	RGD:1566394
Others	ADAM8	NCBI