ADAM8 - ADAM metallopeptidase domain 8 Gene

Also Known as MS2; CD156; CD156a

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 101

About ADAM8

Cytogenetic location: 10q26.3 Genomic coordinates (GRCh38): 10:133,262,423-133,276,868 (from NCBI)

This gene has 11 transcripts (splice variants), 245 orthologues and 20 paralogues. Biased expression in bone marrow (RPKM 22.3), spleen (RPKM 13.4) and 12 other tissues.

Summary

This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The protein encoded by this gene may be involved in cell adhesion during neurodegeneration, and it is thought to be a target for allergic respiratory diseases, including asthma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2009]

ADAM8 Products (8)

mRNA Protein Name
XR_007061938.1
XM_047424425.1 XP_047280381.1 disintegrin and metalloproteinase domain-containing protein 8 isoform X3
XM_047424423.1 XP_047280379.1 disintegrin and metalloproteinase domain-containing protein 8 isoform X1
NM_001164489.2 NP_001157961.1 disintegrin and metalloproteinase domain-containing protein 8 isoform 2 precursor
NM_001164490.2 NP_001157962.1 disintegrin and metalloproteinase domain-containing protein 8 isoform 3
NM_001109.5 NP_001100.3 disintegrin and metalloproteinase domain-containing protein 8 isoform 1 precursor
XM_047424424.1 XP_047280380.1 disintegrin and metalloproteinase domain-containing protein 8 isoform X2
XM_047424426.1 XP_047280382.1 disintegrin and metalloproteinase domain-containing protein 8 isoform X4

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables immunoglobulin receptor binding IPI
IPI: Inferred from physical interaction
12777399 GOA
enables metallopeptidase activity IDA
IDA: Inferred from direct assay
12777399 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
15574124 GOA
enables tumor necrosis factor receptor superfamily binding IPI
IPI: Inferred from physical interaction
12777399 GOA
Biological Process GO Annotation Evidence References Source
involved in cellular response to hypoxia IDA
IDA: Inferred from direct assay
18566576 GOA
involved in inflammatory response IDA
IDA: Inferred from direct assay
12777399 GOA
involved in positive regulation of membrane protein ectodomain proteolysis IDA
IDA: Inferred from direct assay
15220135 GOA
involved in positive regulation of neutrophil extravasation IDA
IDA: Inferred from direct assay
17548643 GOA
involved in regulation of cell-cell adhesion IDA
IDA: Inferred from direct assay
17548643 GOA
involved in signal release IDA
IDA: Inferred from direct assay
12777399 GOA
Cellular Component GO Annotation Evidence References Source
located in cell surface IDA
IDA: Inferred from direct assay
17548643 GOA
located in cytoplasm IDA
IDA: Inferred from direct assay
18397961 GOA
located in dense core granule membrane IDA
IDA: Inferred from direct assay
17548643 GOA
located in phagolysosome IDA
IDA: Inferred from direct assay
17548643 GOA
located in plasma membrane IDA
IDA: Inferred from direct assay
17548643 GOA
located in podosome IDA
IDA: Inferred from direct assay
15220135 GOA
located in specific granule IDA
IDA: Inferred from direct assay
17548643 GOA
located in tertiary granule IDA
IDA: Inferred from direct assay
17548643 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ADAM8 Protein Structure

Pep_M12B_propep

Pep_M12B_propep: Reprolysin family propeptide (29 - 155)

Reprolysin

Reprolysin: Reprolysin (M12B) family zinc metalloprotease (200 - 400)

Disintegrin

Disintegrin: Disintegrin (417 - 491)

ADAM_CR

ADAM_CR: ADAM cysteine-rich (494 - 567)

  • 0
  • 200
  • 400
  • 600
  • 824 a.a.
Protein Preferred Names Protein Names

disintegrin and metalloproteinase domain-containing protein 8

  • a disintegrin and metalloproteinase domain 8

  • cell surface antigen MS2

  • human leukocyte differentiation antigen

ADAM8 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
ADAM8 P78325 TEC Homo sapiens P42680
Phage Display
25825872
Intra
ADAM8 P78325 TEC Homo sapiens P42680
Peptide Array
25825872
Intra
ADAM8 P78325 NCF1 Homo sapiens P14598
Phage Display
25825872
Intra
ADAM8 P78325 NCF1 Homo sapiens P14598
Peptide Array
25825872
Intra
ADAM8 P78325 FNBP1L Homo sapiens Q5T0N5
Phage Display
25825872
Intra
ADAM8 P78325 FNBP1L Homo sapiens Q5T0N5
Peptide Array
25825872
Intra
ADAM8 P78325 TRIP10 Homo sapiens Q15642
Peptide Array
25825872
Intra
ADAM8 P78325 TRIP10 Homo sapiens Q15642
Phage Display
25825872
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant ADAM8 Proteins

Cat. No. Product Name Accession Purity
HY-P75532 ADAM8 Protein, Human (HEK293, His) AAI15405.1 (I17-P655) ≥ 95%, as determined by reducing SDS-PAGE or Bis-Tris PAGE.

ADAM8 Antibodies

Cat. No. Product Name Application Reactivity
HY-P83502 MS2 Antibody (YA3247) WB, IP Human, Mouse
HY-P83502A MS2 Antibody (YA3247)(PBS only) WB, IP Human, Mouse
HY-P84436 MS2 Antibody (YA4133) IHC-P, ICC/IF, FC, ELISA Human
HY-P84436A MS2 Antibody (YA4133)(PBS only) IHC-P, ICC/IF, FC, ELISA Human

Related Diseases

Diseases Alias
Asthma

  • Chronic Obstructive Asthma

  • Asthma, Diminished Response To Antileukotriene Treatment In

  • Bronchial Hyperreactivity

  • Asthma, Susceptibility To

  • Asthma, Bronchial

  • Asthma, Protection Against

  • Asthma, Nocturnal, Susceptibility To

  • Nocturnal Asthma

  • Asthma-Related Traits

  • Asthma-Related Traits, Susceptibility To

  • Asthma, Nocturnal

  • Chronic Obstructive Asthma With Acute Exacerbation

  • Chronic Obstructive Asthma With Status Asthmaticus

  • Exercise Induced Asthma

  • Exercise-Induced Asthma

  • Bronchial Asthma

  • Asthma, Exercise-Induced

  • Idiosyncratic Asthma

  • Unspecified Asthma With Acute Exacerbation

  • Asthma, Unspecified, With Stated Status Asthmaticus

  • Status Asthmaticus Nos

  • Acute Severe Asthma

  • Acute Severe Bronchial Asthma

  • Status Asthma

  • Status Post Asthmaticus
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-120852 JG26 Inhibitor 98.14% Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta ADAM8 VGNC VGNC:69494
Mus musculus ADAM8 MGD MGI:107825
Canis familiaris ADAM8 VGNC VGNC:37587
Bos taurus ADAM8 VGNC VGNC:25612
Felis catus ADAM8 VGNC VGNC:59584
Rattus norvegicus ADAM8 RGD RGD:1566394
Others ADAM8 NCBI