Adamts1 - a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 1 Gene

Also Known as C3-C5; METH1; ADAMTS; METH-1; ADAM-TS1; ADAMTS-1

Species: Mus musculus

Gene Type: protein coding
Gene ID: 11504

Summary

This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motif) family and preproprotein that is proteolytically processed to generate a mature protein product. This secreted protein product plays an important role in ovulation, likely through its cleavage of the extracellular matrix component versican. The encoded protein may enhance tumorigenesis in a mouse model of breast Cancer. Homozygous knockout mice for this gene exhibit enhanced perinatal lethality, impaired growth and adipose tissue development, and impaired ovulation in females. [provided by RefSeq, Oct 2015]

Adamts1 Products (1)

mRNA Protein Name
NM_009621.5 NP_033751.3 A disintegrin and metalloproteinase with thrombospondin motifs 1 preproprotein

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables heparin binding IDA
IDA: Inferred from direct assay
8995297 MGI
enables metalloendopeptidase activity IDA
IDA: Inferred from direct assay
16061471 MGI
enables metalloendopeptidase activity IMP
IMP: Inferred from mutant phenotype
16061471 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
16061471 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within heart trabecula formation IMP
IMP: Inferred from mutant phenotype
18267097 MGI
acts upstream of or within kidney development IMP
IMP: Inferred from mutant phenotype
14668204 MGI
acts upstream of or within ovulation from ovarian follicle IMP
IMP: Inferred from mutant phenotype
14668204 MGI
Cellular Component GO Annotation Evidence References Source
located in basement membrane IDA
IDA: Inferred from direct assay
16061471 MGI
located in cytoplasmic vesicle IDA
IDA: Inferred from direct assay
12907688 MGI
located in extracellular matrix IDA
IDA: Inferred from direct assay
9593739 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

A disintegrin and metalloproteinase with thrombospondin motifs 1

  • ADAM-TS 1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS00291 ADAMTS1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18432 Adamts5 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19084 Adamts1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25574 Adamts1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Adamts1 NCBI NCBI:9510