Adora1 - adenosine A1 receptor Gene

Also Known as Ri; A1R; A1AR; AA1R; ARA1; A1-AR

Species: Mus musculus

Gene Type: protein coding
Gene ID: 11539

About Adora1

Chromosome 1: 134,126,961-134,163,169 reverse strand.GRCm39:CM000994.3

This gene has 4 transcripts (splice variants), 274 orthologues, 3 paralogues and is associated with 20 phenotypes. Biased expression in adrenal adult (RPKM 63.), cerebellum adult (RPKM 3.8) and 13 other tissues.

Summary

Predicted to enable several functions, including G protein-coupled Adenosine Receptor activity; G-protein beta/gamma-subunit complex binding activity; and heterotrimeric G-protein binding activity. Involved in regulation of sensory perception of pain. Acts upstream of or within several processes, including excitatory postsynaptic potential; negative regulation of long-term synaptic depression; and negative regulation of mucus secretion. Located in dendritic spine. Is expressed in several structures, including adipose tissue; alimentary system; brain; genitourinary system; and heart. Human ortholog(s) of this gene implicated in asthma. Orthologous to human ADORA1 (adenosine A1 receptor). [provided by Alliance of Genome Resources, Apr 2022]

Adora1 Products (5)

mRNA Protein Name
NM_001291928.1 NP_001278857.1 adenosine receptor A1 isoform b
NM_001282945.1 NP_001269874.1 adenosine receptor A1 isoform a
NM_001291930.1 NP_001278859.1 adenosine receptor A1 isoform c
NM_001039510.2 NP_001034599.1 adenosine receptor A1 isoform a
NM_001008533.3 NP_001008533.1 adenosine receptor A1 isoform a

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
24259587 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within excitatory postsynaptic potential IDA
IDA: Inferred from direct assay
17428973 MGI
acts upstream of leukocyte migration IGI
IGI: Inferred from genetic interaction
15630442 MGI
acts upstream of long-term synaptic depression IGI
IGI: Inferred from genetic interaction
24259587 MGI
acts upstream of long-term synaptic depression IMP
IMP: Inferred from mutant phenotype
24259587 MGI
acts upstream of mucus secretion IGI
IGI: Inferred from genetic interaction
15630442 MGI
acts upstream of or within negative regulation of inflammatory response IGI
IGI: Inferred from genetic interaction
15630442 MGI
acts upstream of or within negative regulation of leukocyte migration IGI
IGI: Inferred from genetic interaction
15630442 MGI
acts upstream of or within negative regulation of long-term synaptic depression IGI
IGI: Inferred from genetic interaction
24259587 MGI
acts upstream of or within negative regulation of long-term synaptic depression IMP
IMP: Inferred from mutant phenotype
24259587 MGI
acts upstream of or within negative regulation of mucus secretion IGI
IGI: Inferred from genetic interaction
15630442 MGI
acts upstream of or within regulation of glomerular filtration IMP
IMP: Inferred from mutant phenotype
15283758 MGI
involved in regulation of sensory perception of pain IMP
IMP: Inferred from mutant phenotype
18940592 MGI
Cellular Component GO Annotation Evidence References Source
located in dendritic spine IDA
IDA: Inferred from direct assay
24259587 MGI
located in synapse IDA
IDA: Inferred from direct assay
24259587 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Adora1 Protein Structure

7tmA_Adenosine_R_A1

7tmA_Adenosine_R_A1: cd15071 (9 - 36)

7tmA_Adenosine_R_A1

7tmA_Adenosine_R_A1: cd15071 (9 - 298)

7tmA_Adenosine_R_A1

7tmA_Adenosine_R_A1: cd15071 (43 - 70)

7tmA_Adenosine_R_A1

7tmA_Adenosine_R_A1: cd15071 (79 - 109)

7tmA_Adenosine_R_A1

7tmA_Adenosine_R_A1: cd15071 (123 - 141)

7tmA_Adenosine_R_A1

7tmA_Adenosine_R_A1: cd15071 (176 - 206)

7tmA_Adenosine_R_A1

7tmA_Adenosine_R_A1: cd15071 (226 - 256)

7tmA_Adenosine_R_A1

7tmA_Adenosine_R_A1: cd15071 (266 - 291)

  • 0
  • 100
  • 200
  • 300
  • 326 a.a.
Protein Preferred Names Protein Names

adenosine receptor A1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS00391 ADORA1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS00392 Adora1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS00393 Adora1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-180879 ADORA1 modulator-1 / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Adora1 NCBI NCBI:134