Adora2a - adenosine A2a receptor Gene

Also Known as A2aR; A2AAR; AA2AR; ARA2A

Species: Mus musculus

Gene Type: protein coding
Gene ID: 11540

About Adora2a

Chromosome 10: 75,152,711-75,170,618 forward strand.GRCm39:CM001003.3

This gene has 4 transcripts (splice variants), 263 orthologues, 3 paralogues and is associated with 42 phenotypes. Broad expression in thymus adult (RPKM 8.8), spleen adult (RPKM 8.) and 26 other tissues.

Summary

Enables G protein-coupled Adenosine Receptor activity. Acts upstream of or within several processes, including G protein-coupled receptor signaling pathway; chemical synaptic transmission; and positive regulation of cell communication. Located in plasma membrane. Is expressed in several structures, including brain; genitourinary system; hemolymphoid system gland; intestine; and liver and biliary system. Used to study myopia and primary pulmonary hypertension. Human ortholog(s) of this gene implicated in asthma. Orthologous to human ADORA2A (adenosine A2a receptor). [provided by Alliance of Genome Resources, Apr 2022]

Adora2a Products (6)

mRNA Protein Name
NM_009630.3 NP_033760.2 adenosine receptor A2a
NM_001331095.1 NP_001318024.1 adenosine receptor A2a
NM_001331096.1 NP_001318025.1 adenosine receptor A2a
NM_001331095.1 NP_001318024.1 adenosine receptor A2a
NM_001331096.1 NP_001318025.1 adenosine receptor A2a
NM_009630.3 NP_033760.2 adenosine receptor A2a

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables G protein-coupled adenosine receptor activity IDA
IDA: Inferred from direct assay
8157966 MGI
enables G protein-coupled adenosine receptor activity IMP
IMP: Inferred from mutant phenotype
10845921 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within G protein-coupled adenosine receptor signaling pathway IDA
IDA: Inferred from direct assay
12223546 MGI
involved in G protein-coupled adenosine receptor signaling pathway IDA
IDA: Inferred from direct assay
8157966 MGI
acts upstream of or within G protein-coupled adenosine receptor signaling pathway IGI
IGI: Inferred from genetic interaction
12223546 MGI
acts upstream of or within G protein-coupled adenosine receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
10845921 MGI
acts upstream of or within G protein-coupled receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
11404425 MGI
acts upstream of or within adenylate cyclase-activating G protein-coupled receptor signaling pathway IDA
IDA: Inferred from direct assay
8738226 MGI
acts upstream of or within adenylate cyclase-activating G protein-coupled receptor signaling pathway IGI
IGI: Inferred from genetic interaction
12223546 MGI
acts upstream of or within adenylate cyclase-activating G protein-coupled receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
10845921 MGI
acts upstream of apoptotic signaling pathway IMP
IMP: Inferred from mutant phenotype
10845921 MGI
acts upstream of or within eating behavior IGI
IGI: Inferred from genetic interaction
12538862 MGI
acts upstream of or within inhibitory postsynaptic potential IGI
IGI: Inferred from genetic interaction
10704492 MGI
acts upstream of or within locomotory behavior IGI
IGI: Inferred from genetic interaction
10908627 MGI
acts upstream of or within negative regulation of alpha-beta T cell activation IDA
IDA: Inferred from direct assay
10069416 MGI
acts upstream of or within negative regulation of inflammatory response IGI
IGI: Inferred from genetic interaction
17601796 MGI
acts upstream of or within positive regulation of apoptotic signaling pathway IMP
IMP: Inferred from mutant phenotype
10845921 MGI
acts upstream of or within positive regulation of synaptic transmission, GABAergic IDA
IDA: Inferred from direct assay
10934242 MGI
acts upstream of or within positive regulation of synaptic transmission, GABAergic IGI
IGI: Inferred from genetic interaction
10934242 MGI
acts upstream of or within response to amphetamine IMP
IMP: Inferred from mutant phenotype
11172060 MGI
acts upstream of or within synaptic transmission, dopaminergic IGI
IGI: Inferred from genetic interaction
12538862 MGI
Cellular Component GO Annotation Evidence References Source
located in membrane IDA
IDA: Inferred from direct assay
8738226 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
12817016 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Adora2a Protein Structure

7tmA_Adenosine_R_A2A

7tmA_Adenosine_R_A2A: cd15068 (3 - 293)

7tmA_Adenosine_R_A2A

7tmA_Adenosine_R_A2A: cd15068 (4 - 30)

7tmA_Adenosine_R_A2A

7tmA_Adenosine_R_A2A: cd15068 (37 - 64)

7tmA_Adenosine_R_A2A

7tmA_Adenosine_R_A2A: cd15068 (73 - 103)

7tmA_Adenosine_R_A2A

7tmA_Adenosine_R_A2A: cd15068 (117 - 135)

7tmA_Adenosine_R_A2A

7tmA_Adenosine_R_A2A: cd15068 (168 - 198)

7tmA_Adenosine_R_A2A

7tmA_Adenosine_R_A2A: cd15068 (220 - 250)

7tmA_Adenosine_R_A2A

7tmA_Adenosine_R_A2A: cd15068 (261 - 286)

  • 0
  • 100
  • 200
  • 300
  • 410 a.a.
Protein Preferred Names Protein Names

adenosine receptor A2a

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-170397 ADORA2A/PDE4D-IN-1 / Unkown
HY-RS00394 ADORA2A Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS00395 Adora2a Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS00396 Adora2a Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Adora2a NCBI NCBI:135