Adsl - adenylosuccinate lyase Gene

Also Known as Adl; Asl

Species: Mus musculus

Gene Type: protein coding
Gene ID: 11564

Summary

This gene encodes a protein that is involved in adenosine monophosphate (AMP) biosynthesis and maintaining AMP levels in the muscle. The encoded enzyme catalyzes the release of fumarate during AMP biosynthesis by cleaving the substrates succinylaminoimidazole carboxamide (SAICA) ribotide to give aminoimidazole carboxamide (AICA) ribotide, and adenylosuccinate to give adenylate. In humans, this gene is associated with adenylosuccinate deficiency, a rare autosomal disorder resulting in a spectrum of neurological symptoms. A pseudogene associated with this gene is located on the X chromosome. [provided by RefSeq, Jan 2013]

Adsl Products (1)

mRNA Protein Name
NM_009634.6 NP_033764.2 adenylosuccinate lyase

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido) succinate lyase (fumarate-forming) activity IMP
IMP: Inferred from mutant phenotype
6480832 MGI
enables N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity IDA
IDA: Inferred from direct assay
5891253 MGI
Biological Process GO Annotation Evidence References Source
involved in 'de novo' AMP biosynthetic process IDA
IDA: Inferred from direct assay
5891253 MGI
involved in 'de novo' AMP biosynthetic process IMP
IMP: Inferred from mutant phenotype
6480832 MGI
involved in 'de novo' IMP biosynthetic process IMP
IMP: Inferred from mutant phenotype
6480832 MGI
involved in 'de novo' XMP biosynthetic process IMP
IMP: Inferred from mutant phenotype
6480832 MGI
involved in AMP salvage IDA
IDA: Inferred from direct assay
25681585 MGI
involved in GMP biosynthetic process IMP
IMP: Inferred from mutant phenotype
6480832 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

adenylosuccinate lyase

  • ASase

  • adenylosuccinase

  • adenylosuccinate lyase 1

Related Agents

  • Approval
  • Pre-clinical Phase

Approval

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-109056 Elsulfavirine Inhibitor 99.90% Unkown

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-109056A Elsulfavirine sodium Inhibitor / Unkown
HY-RS00418 ADSL Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18123 Adsl Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24597 Adsl Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Adsl NCBI NCBI:158