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Agtr2 - angiotensin II receptor, type 2 Gene

Species: Mus musculus

Gene Type: protein coding

Gene ID: 11609

About Agtr2

Chromosome X: 21,350,783-21,355,403 forward strand.GRCm39:CM001013.3

This gene has 2 transcripts (splice variants), 192 orthologues, 9 paralogues and is associated with 104 phenotypes. Biased expression in limb E14.5 (RPKM 7.4) and CNS E14 (RPKM 3.9).

Summary

Enables angiotensin type II receptor activity. Involved in several processes, including G protein-coupled receptor signaling pathway coupled to cGMP nucleotide second messenger; metanephros development; and positive regulation of branching involved in ureteric bud morphogenesis. Acts upstream of or within angiotensin-mediated vasodilation involved in regulation of systemic arterial blood pressure; brain renin-angiotensin system; and inflammatory response. Predicted to be located in perinuclear region of cytoplasm. Predicted to be active in plasma membrane. Is expressed in several structures, including alimentary system; brain; extraembryonic component; genitourinary system; and limb. Human ortholog(s) of this gene implicated in IgA glomerulonephritis; end stage renal disease; hypoglycemia; intellectual disability; and vesicoureteral reflux. Orthologous to human AGTR2 (angiotensin II receptor type 2). [provided by Alliance of Genome Resources, Apr 2022]

Agtr2 Products (1)

mRNA	Protein	Name
NM_007429.5	NP_031455.1	type-2 angiotensin II receptor

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables angiotensin type II receptor activity	IDA IDA: Inferred from direct assay	9878677	MGI
enables angiotensin type II receptor activity	IPI IPI: Inferred from physical interaction	9878677	MGI

Biological Process GO Annotation	Evidence	References	Source
involved in G protein-coupled receptor signaling pathway coupled to cGMP nucleotide second messenger	IDA IDA: Inferred from direct assay	17000928	MGI
acts upstream of or within angiotensin-mediated vasodilation involved in regulation of systemic arterial blood pressure	IMP IMP: Inferred from mutant phenotype	10425188	MGI
acts upstream of or within brain renin-angiotensin system	IDA IDA: Inferred from direct assay	9878677	MGI
involved in exploration behavior	IMP IMP: Inferred from mutant phenotype	7477267	MGI
acts upstream of or within inflammatory response	IGI IGI: Inferred from genetic interaction	19404405	MGI
involved in negative regulation of heart rate	IMP IMP: Inferred from mutant phenotype	9449684	MGI
NOT acts upstream of or within negative regulation of neuron apoptotic process	IMP IMP: Inferred from mutant phenotype	9310306	MGI
acts upstream of neuron apoptotic process	IMP IMP: Inferred from mutant phenotype	9310306	MGI
involved in nitric oxide-cGMP-mediated signaling	IDA IDA: Inferred from direct assay	17000928	MGI
involved in positive regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	15153556	MGI
involved in positive regulation of branching involved in ureteric bud morphogenesis	IMP IMP: Inferred from mutant phenotype	18607644	MGI
involved in positive regulation of metanephric glomerulus development	IMP IMP: Inferred from mutant phenotype	18607644	MGI
involved in regulation of metanephros size	IMP IMP: Inferred from mutant phenotype	18607644	MGI
involved in regulation of systemic arterial blood pressure by circulatory renin-angiotensin	IMP IMP: Inferred from mutant phenotype	7477267	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Agtr2 Protein Structure

7tmA_AT2R

0
100
200
300
363 a.a.

Protein Preferred Names	Protein Names
type-2 angiotensin II receptor	AT2 receptor angiotensin II type-2 receptor

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00469	AGTR2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS00470	Agtr2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS00471	Agtr2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Agtr2	NCBI	NCBI:186