Agtr2 - angiotensin II receptor, type 2 Gene

Mus musculus

Gene ID: 11609 | Gene type: protein coding

About Agtr2

Chromosome X: 21,350,783-21,355,403 forward strand.GRCm39:CM001013.3

This gene has 2 transcripts (splice variants), 192 orthologues, 9 paralogues and is associated with 104 phenotypes. Biased expression in limb E14.5 (RPKM 7.4) and CNS E14 (RPKM 3.9).

Summary

Enables angiotensin type II receptor activity. Involved in several processes, including G protein-coupled receptor signaling pathway coupled to cGMP nucleotide second messenger; metanephros development; and positive regulation of branching involved in ureteric bud morphogenesis. Acts upstream of or within angiotensin-mediated vasodilation involved in regulation of systemic arterial blood pressure; brain renin-angiotensin system; and inflammatory response. Predicted to be located in perinuclear region of cytoplasm. Predicted to be active in plasma membrane. Is expressed in several structures, including alimentary system; brain; extraembryonic component; genitourinary system; and limb. Human ortholog(s) of this gene implicated in IgA glomerulonephritis; end stage renal disease; hypoglycemia; intellectual disability; and vesicoureteral reflux. Orthologous to human AGTR2 (angiotensin II receptor type 2). [provided by Alliance of Genome Resources, Apr 2022]

Agtr2 Products(1)

mRNA	Protein	Name
NM_007429.5	NP_031455.1	type-2 angiotensin II receptor

Agtr2 Protein Structure

7tmA_AT2R

0
100
200
300
363 a.a.

Protein Preferred Names

Protein Names

type-2 angiotensin II receptor

AT2 receptor

angiotensin II type-2 receptor

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Purity	Rare Diseases
HY-RS00469	AGTR2 Human Pre-designed siRNA Set A	/	Unkown
HY-RS00470	Agtr2 Mouse Pre-designed siRNA Set A	/	Unkown
HY-RS00471	Agtr2 Rat Pre-designed siRNA Set A	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Agtr2	NCBI	NCBI:186

Name
Email *

	Sorry, but the email address you supplied was invalid.