Bak1 - BCL2-antagonist/killer 1 Gene

Also Known as Bak

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 116502

About Bak1

Primary_assembly 20: 5,100,480-5,109,264 reverse strand.mRatBN7.2:CM026993.1

This gene has 1 transcript (splice variant), 135 orthologues, 13 paralogues and is associated with 15 phenotypes. Biased expression in Thymus (RPKM 137.4), Spleen (RPKM 16.9) and 9 other tissues.

Summary

Enables several functions, including chaperone binding activity; heat shock protein binding activity; and identical protein binding activity. Involved in several processes, including animal organ development; positive regulation of release of cytochrome c from mitochondria; and release of cytochrome c from mitochondria. Located in cytosol; membrane; and mitochondrion. Biomarker of intermittent claudication. Human ortholog(s) of this gene implicated in ataxia telangiectasia and cervix carcinoma. Orthologous to human BAK1 (BCL2 antagonist/killer 1). [provided by Alliance of Genome Resources, Apr 2022]

Bak1 Products (1)

mRNA Protein Name
NM_053812.2 NP_446264.1 bcl-2 homologous antagonist/killer

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables BH domain binding IPI
IPI: Inferred from physical interaction
9356461 RGD
enables heat shock protein binding IPI
IPI: Inferred from physical interaction
12070120 RGD
enables identical protein binding IPI
IPI: Inferred from physical interaction
12454021 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
15004018 RGD
enables protein-containing complex binding IPI
IPI: Inferred from physical interaction
9356461 RGD
enables protein-folding chaperone binding IPI
IPI: Inferred from physical interaction
12070120 RGD
Biological Process GO Annotation Evidence References Source
involved in animal organ regeneration IEP
IEP: Inferred from expression pattern
11232245 RGD
involved in endocrine pancreas development IEP
IEP: Inferred from expression pattern
11000281 RGD
involved in negative regulation of cell population proliferation IMP
IMP: Inferred from mutant phenotype
18349538 RGD
involved in negative regulation of gene expression IMP
IMP: Inferred from mutant phenotype
18349538 RGD
involved in positive regulation of release of cytochrome c from mitochondria IMP
IMP: Inferred from mutant phenotype
12485416 RGD
involved in release of cytochrome c from mitochondria IMP
IMP: Inferred from mutant phenotype
18252800 RGD
involved in response to UV-C IEP
IEP: Inferred from expression pattern
19520675 RGD
involved in response to ethanol IEP
IEP: Inferred from expression pattern
20028358 RGD
involved in response to hydrogen peroxide IEP
IEP: Inferred from expression pattern
19143845 RGD
involved in response to organic cyclic compound IEP
IEP: Inferred from expression pattern
18817839 RGD
involved in response to xenobiotic stimulus IEP
IEP: Inferred from expression pattern
15875735 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Bak1 Protein Structure

Bcl-2_like

Bcl-2_like: cd06845 (26 - 180)

  • 0
  • 100
  • 209 a.a.
Protein Preferred Names Protein Names

bcl-2 homologous antagonist/killer

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (9)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-162858 BRD-810 98.00% Unkown
HY-129461 Dibenzyl trisulfide Inducer 98.24% Unkown
HY-183601 Mcl-1-IN-22 / Unkown
HY-E70788 BARK1 Recombinant Human Active Protein Kinase / Unkown
HY-RS01357 BAK1 Human Pre-designed siRNA Set A / Unkown
HY-RS01358 Bak1 Mouse Pre-designed siRNA Set A / Unkown
HY-RS01359 Bak1 Rat Pre-designed siRNA Set A / Unkown
HY-136999 7-O-Methyleucomol / Unkown
HY-174777 Human BAK1 mRNA / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Bak1 NCBI NCBI:578