P2ry6 - pyrimidinergic receptor P2Y6 Gene

Also Known as P2y6

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 117264

About P2ry6

Primary_assembly 1: 155,295,111-155,330,808 reverse strand.mRatBN7.2:CM026974.1

This gene has 5 transcripts (splice variants), 183 orthologues, 13 paralogues and is associated with 1 phenotype. Biased expression in Spleen (RPKM 12.8), Heart (RPKM 6.9) and 9 other tissues.

Summary

Predicted to enable G protein-coupled ADP receptor activity; G protein-coupled UDP receptor activity; and G protein-coupled UTP receptor activity. Involved in several processes, including cellular response to pyrimidine ribonucleotide; positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity; and positive regulation of smooth muscle cell migration. Located in apical plasma membrane and basolateral plasma membrane. Orthologous to human P2RY6 (pyrimidinergic receptor P2Y6). [provided by Alliance of Genome Resources, Apr 2022]

P2ry6 Products (1)

mRNA Protein Name
NM_057124.2 NP_476465.1 P2Y purinoceptor 6

Gene Ontology

  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence References Source
involved in cellular response to pyrimidine ribonucleotide IMP
IMP: Inferred from mutant phenotype
17410128 RGD
involved in phagocytosis IMP
IMP: Inferred from mutant phenotype
17410128 RGD
involved in positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity IMP
IMP: Inferred from mutant phenotype
17410128 RGD
involved in positive regulation of smooth muscle cell migration IMP
IMP: Inferred from mutant phenotype
11934835 RGD
Cellular Component GO Annotation Evidence References Source
located in apical plasma membrane IDA
IDA: Inferred from direct assay
11557527 RGD
located in basolateral plasma membrane IDA
IDA: Inferred from direct assay
11557527 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

P2ry6 Protein Structure

7tm_GPCRs

7tm_GPCRs: cl28897 (26 - 311)

7tm_GPCRs

7tm_GPCRs: cd14964 (28 - 52)

7tm_GPCRs

7tm_GPCRs: cd14964 (61 - 82)

7tm_GPCRs

7tm_GPCRs: cd14964 (99 - 121)

7tm_GPCRs

7tm_GPCRs: cd14964 (145 - 161)

7tm_GPCRs

7tm_GPCRs: cd14964 (189 - 212)

7tm_GPCRs

7tm_GPCRs: cd14964 (237 - 259)

7tm_GPCRs

7tm_GPCRs: cd14964 (279 - 304)

  • 0
  • 100
  • 200
  • 300
  • 328 a.a.
Protein Preferred Names Protein Names

P2Y purinoceptor 6

  • P2Y ATP receptor 6

  • pyrimidinergic receptor P2Y, G-protein coupled, 6

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS09934 P2RY6 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-117356A MRS2693 ammonium / Unkown
HY-RS09935 P2ry6 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS09936 P2ry6 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens P2ry6 NCBI NCBI:5031