Nr0b2 - nuclear receptor subfamily 0, group B, member 2 Gene

Also Known as Shp

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 117274

Summary

Enables peroxisome proliferator activated receptor binding activity; retinoid X receptor binding activity; and Thyroid Hormone Receptor binding activity. Involved in several processes, including animal organ regeneration; bile acid and bile salt transport; and positive regulation of Insulin secretion. Part of protein-containing complex. Biomarker of alcoholic hepatitis; diabetes mellitus; and intrahepatic cholestasis. Human ortholog(s) of this gene implicated in obesity and type 2 diabetes mellitus. Orthologous to human NR0B2 (nuclear receptor subfamily 0 group B member 2). [provided by Alliance of Genome Resources, Apr 2022]

Nr0b2 Products (1)

mRNA Protein Name
NM_057133.1 NP_476474.1 nuclear receptor subfamily 0 group B member 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables nuclear retinoic acid receptor binding IPI
IPI: Inferred from physical interaction
9003453 RGD
enables nuclear retinoid X receptor binding IPI
IPI: Inferred from physical interaction
9003453 RGD
enables nuclear thyroid hormone receptor binding IPI
IPI: Inferred from physical interaction
9003453 RGD
enables peroxisome proliferator activated receptor binding IPI
IPI: Inferred from physical interaction
9003453 RGD
enables protein-containing complex binding IDA
IDA: Inferred from direct assay
10648597 RGD
Biological Process GO Annotation Evidence References Source
involved in animal organ regeneration IEP
IEP: Inferred from expression pattern
15904869 RGD
involved in bile acid and bile salt transport IEP
IEP: Inferred from expression pattern
27939985 RGD
involved in negative regulation of DNA-templated transcription IMP
IMP: Inferred from mutant phenotype
15860571 RGD
involved in negative regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
15860571 RGD
involved in positive regulation of insulin secretion IMP
IMP: Inferred from mutant phenotype
17259388 RGD
involved in response to ethanol IEP
IEP: Inferred from expression pattern
27939985 RGD
involved in response to glucose IMP
IMP: Inferred from mutant phenotype
17259388 RGD
involved in response to organic cyclic compound IEP
IEP: Inferred from expression pattern
27939985 RGD
Cellular Component GO Annotation Evidence References Source
part of protein-containing complex IDA
IDA: Inferred from direct assay
10648597 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

nuclear receptor subfamily 0 group B member 2

  • orphan nuclear receptor SHP

  • small heterodimer partner homologue

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS09526 NR0B2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21668 Nr0b2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28186 Nr0b2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Nr0b2 NCBI NCBI:8431