Keap1 - Kelch-like ECH-associated protein 1 Gene

Also Known as Inrf2

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 117519

About Keap1

Primary_assembly 8: 19,768,375-19,777,862 reverse strand.mRatBN7.2:CM026981.1

This gene has 2 transcripts (splice variants), 189 orthologues, 53 paralogues and is associated with 28 phenotypes. Biased expression in Muscle (RPKM 121.2), Adrenal (RPKM 18.2) and 9 other tissues.

Summary

Predicted to enable disordered domain specific binding activity and identical protein binding activity. Involved in several processes, including regulation of gene expression; response to thyroid hormone; and selenium compound metabolic process. Located in several cellular components, including adherens junction; focal adhesion; and nucleus. Part of protein-containing complex. Biomarker of diabetic retinopathy; end stage renal disease; and ureteral obstruction. Human ortholog(s) of this gene implicated in gallbladder Cancer. Orthologous to human KEAP1 (kelch like ECH associated protein 1). [provided by Alliance of Genome Resources, Apr 2022]

Keap1 Products (1)

mRNA Protein Name
NM_057152.2 NP_476493.2 kelch-like ECH-associated protein 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
11439354 RGD
Biological Process GO Annotation Evidence References Source
involved in cellular response to carbohydrate stimulus IDA
IDA: Inferred from direct assay
20026152 RGD
involved in cellular response to organic cyclic compound IEP
IEP: Inferred from expression pattern
11439354 RGD
involved in cytoplasmic sequestering of transcription factor IMP
IMP: Inferred from mutant phenotype
11439354 RGD
involved in negative regulation of gene expression IDA
IDA: Inferred from direct assay
20026152 RGD
involved in negative regulation of gene expression IMP
IMP: Inferred from mutant phenotype
11439354 RGD
involved in response to immobilization stress IEP
IEP: Inferred from expression pattern
17316384 RGD
involved in response to metal ion IEP
IEP: Inferred from expression pattern
22649286 RGD
involved in response to thyroid hormone IEP
IEP: Inferred from expression pattern
22649286 RGD
involved in selenium compound metabolic process IEP
IEP: Inferred from expression pattern
16978024 RGD
Cellular Component GO Annotation Evidence References Source
located in adherens junction IDA
IDA: Inferred from direct assay
14506708 RGD
located in focal adhesion IDA
IDA: Inferred from direct assay
14506708 RGD
part of protein-containing complex IDA
IDA: Inferred from direct assay
20026152 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Keap1 Protein Structure

BTB_POZ_KLHL19_KEAP1

BTB_POZ_KLHL19_KEAP1: cd18248 (55 - 179)

PHA03098

PHA03098: cl33709 (94 - 598)

Kelch

Kelch: sd00038 (361 - 408)

Kelch

Kelch: sd00038 (412 - 455)

Kelch

Kelch: sd00038 (459 - 502)

Kelch

Kelch: sd00038 (506 - 550)

Kelch

Kelch: sd00038 (553 - 596)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 624 a.a.
Protein Preferred Names Protein Names

kelch-like ECH-associated protein 1

  • cytosolic inhibitor of Nrf2

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-W012382 N-Acetyl-L-tyrosine 99.48% Unkown

Clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Phase
HY-N0005 Curcumin 98.84% Phase 4
HY-13755 Sulforaphane 99.75% Phase 4
HY-159641 VVD-130037 Activator 99.91% Phase 1

Pre-clinical Phase

Bioactive Molecules (125)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-100218A RSL3 99.87% Unkown
HY-112675 4-Octyl itaconate Activator 99.92% Unkown
HY-19543 Brusatol 99.94% Unkown
HY-101140 KI696 99.26% Unkown
HY-110258 ML334 Activator 99.76% Unkown
HY-134205A CBR-470-1 Activator 98.02% Unkown
HY-113298 Citraconic acid Inhibitor 99.08% Unkown
HY-N0147 Rutaecarpine 99.77% Unkown
HY-N0005R Curcumin (Standard) 98.01% Unkown
HY-N0806 Sweroside 99.76% Unkown
HY-P2048 MOTS-c (human) 99.90% Unkown
HY-13755A (R)-Sulforaphane 99.95% Unkown
HY-P2048A MOTS-c(human) acetate Activator 99.74% Unkown
HY-N0353 Curdione Inhibitor 99.80% Unkown
HY-N1437 Hydroxycitric acid 99.95% Unkown
HY-111126 K67 Inhibitor 98.26% Unkown
HY-N0493 Pectolinarigenin 99.98% Unkown
HY-113162 Bovinic acid ≥99.0% Unkown
HY-149508 Nrf2-IN-3 98.10% Unkown
HY-120371 CPUY192018 Inhibitor 98.90% Unkown
HY-145879 Nrf2 activator-2 Activator 99.20% Unkown
HY-W009731 Dibenzoylmethane Activator 98.0% Unkown
HY-153873 MSU38225 99.94% Unkown
HY-N0260 Epmedin C 99.47% Unkown
HY-110275 RA839 Inhibitor 98.54% Unkown
HY-103435 Vialinin A 99.90% Unkown
HY-131592 Tricetin 99.88% Unkown
HY-B0854 Mancozeb 85.50% Unkown
HY-N0005S Curcumin-d6 99.78% Unkown
HY-N0008 Orcinol glucoside 98.92% Unkown
HY-101140A KI696 isomer 98.44% Unkown
HY-171705 KMS99220 99.48% Unkown
HY-W338584 Hydroxycitric acid tripotassium 98.0% Unkown
HY-100218C (1R,3R)-RSL3 Control 99.05% Unkown
HY-139047 SW157765 Inhibitor 98.08% Unkown
HY-149010 NXPZ-2 Inhibitor 98.55% Unkown
HY-151362 Keap1-Nrf2-IN-14 Inhibitor 98.08% Unkown
HY-169766 VVD 065 Degrader 99.71% Unkown
HY-160876 BC-1901S Activator 99.81% Unkown
HY-P1328 TAT-14 Activator 99.71% Unkown
HY-162152 biKEAP1 Inhibitor 99.44% Unkown
HY-110258B (R,S,R)-ML334 Control 98.57% Unkown
HY-P10530 Nrf2 (69-84) 95.25% Unkown
HY-W012382S N-Acetyl-L-tyrosine-d3 98.44% Unkown
HY-W017187 2-tert-Butyl-1,4-benzoquinone 99.34% Unkown
HY-147517 Keap1-Nrf2-IN-9 Inhibitor 98.52% Unkown
HY-121523 MIND4-17 Activator 99.05% Unkown
HY-150579 Keap1-Nrf2-IN-13 Inhibitor 96.77% Unkown
HY-173444 HDAC11-IN-3 99.70% Unkown
HY-124834 Nrf2 activator-10 98.65% Unkown
HY-146577 Keap1-Nrf2-IN-7 Inhibitor 99.82% Unkown
HY-P5909 Keap1-Nrf2 probe 98.75% Unkown
HY-P5909F FITC-labeled Keap1-Nrf2 probe 98.57% Unkown
HY-RS07231 Keap1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-122054 BPK-29 99.4% Unkown
HY-122054A BPK-29 hydrochloride Inhibitor 99.19% Unkown
HY-178054 LMDP10 Activator 99.91% Unkown
HY-139620 MS83 / Unkown
HY-139620A MS83 epimer 1 98.36% Unkown
HY-113510 9(S)-HOTrE 99.9% Unkown
HY-N8160 Dehydrocurdione 97% Unkown
HY-RS07230 KEAP1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-112675R 4-Octyl itaconate (Standard) Activator / Unkown
HY-124941 7-Deacetylgedunin Activator / Unkown
HY-139862 Keap1-Nrf2-IN-3 Inhibitor / Unkown
HY-141439 TBE 31 / Unkown
HY-143892 Keap1-Nrf2-IN-5 Inhibitor / Unkown
HY-143893 Keap1-Nrf2-IN-6 Inhibitor / Unkown
HY-144099 Keap1-Nrf2-IN-4 / Unkown
HY-146578 Keap1-Nrf2-IN-8 Inhibitor / Unkown
HY-147924 Keap1-Nrf2-IN-11 Inhibitor / Unkown
HY-149245 Keap1-Nrf2-IN-15 Inhibitor / Unkown
HY-150578 Keap1-Nrf2-IN-12 Inhibitor / Unkown
HY-155997 Anti-inflammatory agent 56 Inhibitor / Unkown
HY-156065 S217879 / Unkown
HY-157928 Keap1-Nrf2-IN-18 Inhibitor / Unkown
HY-157929 Keap1-Nrf2-IN-19 Inhibitor / Unkown
HY-159495 Keap1-Nrf2-IN-21 / Unkown
HY-161643 S21-1011 / Unkown
HY-168065 Keap1-Nrf2-IN-22 Inhibitor / Unkown
HY-168161 Keap1-Nrf2-IN-23 Inhibitor / Unkown
HY-168526 Keap1-Nrf2-IN-24 Inhibitor / Unkown
HY-168640 RIP3 activator 1 / Unkown
HY-168709 Nrf2 activator 18 Activator / Unkown
HY-168922 Keap1-Nrf2-IN-25 Inhibitor / Unkown
HY-169315 Nrf2 activator 17 Activator / Unkown
HY-170301 Keap1-IN-1 Inhibitor / Unkown
HY-170761 KEAP1-NRF2 PPI-IN-1 Inhibitor / Unkown
HY-171035 PRL-295 Inhibitor / Unkown
HY-172598 SG16 Inhibitor / Unkown
HY-173039 α-Tubulin polymerization-IN-1 / Unkown
HY-173181 Anticonvulsant agent 10 Inhibitor / Unkown
HY-173187 Keap1-Nrf2-IN-27 Inhibitor / Unkown
HY-174395 CD-10 / Unkown
HY-175217 Nrf2 activator-20 Activator / Unkown
HY-175548 Nrf2 activator-21 / Unkown
HY-175833 NF-κB-IN-20 / Unkown
HY-176146 Keap1/Nrf2/ARE activator 1 Activator / Unkown
HY-178873 PROTAC K-Ras Degrader-7 Degrader / Unkown
HY-179398 Keap1-Nrf2-IN-29 Inhibitor / Unkown
HY-180112 SH543 / Unkown
HY-180155 Keap1/Nrf2/ARE activator 2 / Unkown
HY-181818 4,5-Dehydro-6-oxoallosecurinine / Unkown
HY-181887 Nrf2 activator-23 / Unkown
HY-181907 NBE5 / Unkown
HY-181908 5-Norbornene-2-methylamine-C10-NH2 / Unkown
HY-183353 Nrf2 activator-25 / Unkown
HY-184204 Keap1-p-p62-IN-1 / Unkown
HY-N10313 Dehydrobruceine B / Unkown
HY-N17317 Isostrictiniin / Unkown
HY-N17603 Ginnalin A Activator / Unkown
HY-N19738 Obtusaquinone / Unkown
HY-P1328A TAT-14 TFA Activator / Unkown
HY-P5480 Keap1-Nrf2-IN-16 / Unkown
HY-RS07232 Keap1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W701218 Sulforaphane-d8 / Unkown
HY-112675S 4-Octyl itaconate-13C5-1 / Unkown
HY-147548 Keap1-Nrf2-IN-10 Inhibitor / Unkown
HY-162096 Keap1-Nrf2-IN-17 Inhibitor / Unkown
HY-174287 Keap1-IN-2 Inhibitor / Unkown
HY-182927 KLHL12 ligand-1 / Unkown
HY-183448 ETMTC / Unkown
HY-N0005S1 Curcumin-d3 / Unkown
HY-N0493R Pectolinarigenin (Standard) / Unkown
HY-W505984 TPNA10168 Activator / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Keap1 NCBI NCBI:9817