Tpm3 - tropomyosin 3 Gene

Also Known as Tpm5; TM30nm

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 117557

Summary

Predicted to enable actin filament binding activity. Involved in brain development. Located in brush border. Human ortholog(s) of this gene implicated in congenital fiber-type disproportion and nemaline myopathy 1. Orthologous to human TPM3 (tropomyosin 3). [provided by Alliance of Genome Resources, Apr 2022]

Tpm3 Products (4)

mRNA Protein Name
NM_001301285.1 NP_001288214.1 tropomyosin alpha-3 chain isoform Tpm3.12st
NM_001301286.1 NP_001288215.1 tropomyosin alpha-3 chain isoform Tpm3.3cy
NM_057208.2 NP_476556.2 tropomyosin alpha-3 chain isoform Tpm3.4cy
NM_173111.2 NP_775134.2 tropomyosin alpha-3 chain isoform Tpm3.1cy

Gene Ontology

  • Cellular Component
Cellular Component GO Annotation Evidence References Source
located in brush border IDA
IDA: Inferred from direct assay
22114352 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

tropomyosin alpha-3 chain

  • gamma-tropomyosin

  • nonmuscle tropomyosin 5

  • tropomyosin 3, gamma

  • tropomyosin non-muscle

  • tropomyosin-5

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-137465 CG428 Degrader 98.26% Phase 2

Pre-clinical Phase

Bioactive Molecules (8)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-124689 TR-100 Inhibitor 99.0% Unkown
HY-157542 CG428-NEG Control 97.6% Unkown
HY-131244 ALK-IN-9 Inhibitor / Unkown
HY-175271 JWJ-01-378 / Unkown
HY-RS14938 TPM3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-164514 NMS-P626 Inhibitor / Unkown
HY-RS18503 Tpm3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24985 Tpm3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Tpm3 NCBI NCBI:7170