Nr2f2 - nuclear receptor subfamily 2, group F, member 2 Gene

Also Known as EAR3; ARP-1; SVP40; Aporp1; COUPTFB; COUP-TF2; Tcfcoup2; COUP-TFII; 2700033K02Rik; 9430015G03Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 11819

Summary

Enables sequence-specific DNA binding activity. Acts upstream of or within several processes, including placenta development; regionalization; and vasculature development. Located in nucleus. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; respiratory system; and sensory organ. Used to study congenital diaphragmatic hernia and dilated cardiomyopathy. Human ortholog(s) of this gene implicated in 46,XX sex reversal 5. Orthologous to human NR2F2 (nuclear receptor subfamily 2 group F member 2). [provided by Alliance of Genome Resources, Apr 2022]

Nr2f2 Products (2)

mRNA Protein Name
NM_009697.3 NP_033827.2 COUP transcription factor 2 isoform 1
NM_183261.3 NP_899084.2 COUP transcription factor 2 isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables DNA binding IDA
IDA: Inferred from direct assay
16912278 MGI
enables sequence-specific DNA binding IDA
IDA: Inferred from direct assay
7823919 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within anterior/posterior pattern specification IMP
IMP: Inferred from mutant phenotype
15829524 MGI
acts upstream of or within blood vessel morphogenesis IMP
IMP: Inferred from mutant phenotype
15875024 MGI
acts upstream of or within fertilization IMP
IMP: Inferred from mutant phenotype
17404209 MGI
acts upstream of or within forebrain development IDA
IDA: Inferred from direct assay
15548577 MGI
acts upstream of or within in utero embryonic development IMP
IMP: Inferred from mutant phenotype
17404209 MGI
acts upstream of or within interneuron migration IDA
IDA: Inferred from direct assay
15548577 MGI
involved in lymph vessel development IEP
IEP: Inferred from expression pattern
19210544 MGI
acts upstream of or within maternal placenta development IMP
IMP: Inferred from mutant phenotype
17404209 MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
7823919 MGI
acts upstream of or within neuron migration IDA
IDA: Inferred from direct assay
15548577 MGI
acts upstream of or within placenta blood vessel development IMP
IMP: Inferred from mutant phenotype
17404209 MGI
acts upstream of or within radial pattern formation IMP
IMP: Inferred from mutant phenotype
15829524 MGI
acts upstream of or within regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
19796622 MGI
acts upstream of or within skeletal muscle tissue development IMP
IMP: Inferred from mutant phenotype
16251273 MGI
acts upstream of or within trophoblast giant cell differentiation IMP
IMP: Inferred from mutant phenotype
17404209 MGI
Cellular Component GO Annotation Evidence References Source
located in nucleus IDA
IDA: Inferred from direct assay
15548577 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

COUP transcription factor 2

  • COUP transcription factor II

  • COUP-TF II

  • apolipoprotein AI regulatory protein 1

  • apolipoprotein regulatory protein 1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-156190A NR2F2-IN-1 free base Inhibitor 99.31% Unkown
HY-156190 NR2F2-IN-1 Inhibitor / Unkown
HY-RS09542 NR2F2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20069 Nr2f2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26573 Nr2f2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Nr2f2 NCBI NCBI:7026