Atp7b - ATPase, Cu++ transporting, beta polypeptide Gene

Also Known as tx; WND; Atp7a

Species: Mus musculus

Gene Type: protein coding
Gene ID: 11979

Summary

Enables P-type divalent copper transporter activity. Acts upstream of or within several processes, including cellular transition metal ion homeostasis; lactation; and protein maturation by copper ion transfer. Located in membrane and trans-Golgi network. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; respiratory system; and sensory organ. Used to study Wilson disease. Human ortholog(s) of this gene implicated in Wilson disease. Orthologous to human ATP7B (ATPase copper transporting beta). [provided by Alliance of Genome Resources, Apr 2022]

Atp7b Products (2)

mRNA Protein Name
NM_001403709.1 NP_001390638.1 copper-transporting ATPase 2 isoform 1
NM_007511.3 NP_031537.2 copper-transporting ATPase 2 isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables P-type divalent copper transporter activity IDA
IDA: Inferred from direct assay
11237756 MGI
enables P-type divalent copper transporter activity IMP
IMP: Inferred from mutant phenotype
11237756 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within copper ion transport IDA
IDA: Inferred from direct assay
11237756 MGI
acts upstream of or within copper ion transport IMP
IMP: Inferred from mutant phenotype
11085952 MGI
acts upstream of or within establishment of localization in cell IMP
IMP: Inferred from mutant phenotype
11085952 MGI
acts upstream of or within intracellular copper ion homeostasis IMP
IMP: Inferred from mutant phenotype
1588441 MGI
acts upstream of or within intracellular zinc ion homeostasis IMP
IMP: Inferred from mutant phenotype
8040371 MGI
acts upstream of or within lactation IMP
IMP: Inferred from mutant phenotype
1588441 MGI
acts upstream of or within protein maturation by copper ion transfer IMP
IMP: Inferred from mutant phenotype
16436657 MGI
Cellular Component GO Annotation Evidence References Source
located in membrane IDA
IDA: Inferred from direct assay
10441329 MGI
located in trans-Golgi network IDA
IDA: Inferred from direct assay
11085952 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

copper-transporting ATPase 2

  • Wilson protein

  • copper pump 2

  • toxic milk

  • wilson disease-associated protein homolog

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS01236 ATP7B Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W783351 CS790AM / Unkown
HY-RS17601 Atp7b Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24061 Atp7b Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Atp7b NCBI NCBI:540