Bak1 - BCL2-antagonist/killer 1 Gene

Also Known as Bak; N-Bak; N-BAK1

Species: Mus musculus

Gene Type: protein coding
Gene ID: 12018

About Bak1

Chromosome 17: 27,238,784-27,247,983 reverse strand.GRCm39:CM001010.3

This gene has 4 transcripts (splice variants), 135 orthologues, 10 paralogues and is associated with 3 phenotypes. Broad expression in large intestine adult (RPKM 19.5), duodenum adult (RPKM 17.1) and 25 other tissues.

Summary

Enables identical protein binding activity. Involved in cellular response to UV and release of cytochrome c from mitochondria. Acts upstream of or within several processes, including apoptotic signaling pathway; cellular calcium ion homeostasis; and lymphocyte apoptotic process. Located in cytosol; endoplasmic reticulum; and mitochondrial membrane. Is integral component of mitochondrial outer membrane. Part of Bak complex. Is expressed in several structures, including alimentary system; brain; branchial arch; genitourinary system; and hemolymphoid system gland. Human ortholog(s) of this gene implicated in ataxia telangiectasia and cervix carcinoma. Orthologous to human BAK1 (BCL2 antagonist/killer 1). [provided by Alliance of Genome Resources, Apr 2022]

Bak1 Products (1)

mRNA Protein Name
NM_007523.3 NP_031549.2 bcl-2 homologous antagonist/killer

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables identical protein binding IPI
IPI: Inferred from physical interaction
10950869 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
10950869 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within B cell apoptotic process IGI
IGI: Inferred from genetic interaction
16055554 MGI
acts upstream of or within B cell homeostasis IGI
IGI: Inferred from genetic interaction
15967824 MGI
acts upstream of or within B cell homeostasis IMP
IMP: Inferred from mutant phenotype
16055554 MGI
acts upstream of or within B cell negative selection IGI
IGI: Inferred from genetic interaction
16055554 MGI
acts upstream of or within activation of cysteine-type endopeptidase activity involved in apoptotic process IGI
IGI: Inferred from genetic interaction
12847083 MGI
acts upstream of or within activation of cysteine-type endopeptidase activity involved in apoptotic process IMP
IMP: Inferred from mutant phenotype
16893972 MGI
acts upstream of or within activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c IMP
IMP: Inferred from mutant phenotype
11836241 MGI
acts upstream of or within apoptotic process involved in blood vessel morphogenesis IGI
IGI: Inferred from genetic interaction
15955981 MGI
acts upstream of or within blood vessel remodeling IGI
IGI: Inferred from genetic interaction
15955981 MGI
acts upstream of calcium ion transport into cytosol IGI
IGI: Inferred from genetic interaction
15613488 MGI
involved in cellular response to UV IMP
IMP: Inferred from mutant phenotype
15901672 MGI
acts upstream of or within epithelial cell proliferation IDA
IDA: Inferred from direct assay
9176392 MGI
acts upstream of establishment of localization in cell IGI
IGI: Inferred from genetic interaction
15613488 MGI
acts upstream of or within extrinsic apoptotic signaling pathway in absence of ligand IGI
IGI: Inferred from genetic interaction
15680329 MGI
acts upstream of or within fibroblast apoptotic process IMP
IMP: Inferred from mutant phenotype
15901672 MGI
acts upstream of or within homeostasis of number of cells IGI
IGI: Inferred from genetic interaction
11163212 MGI
acts upstream of or within intrinsic apoptotic signaling pathway in response to DNA damage IGI
IGI: Inferred from genetic interaction
15901672 MGI
acts upstream of or within intrinsic apoptotic signaling pathway in response to DNA damage IMP
IMP: Inferred from mutant phenotype
15901672 MGI
acts upstream of or within intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress IGI
IGI: Inferred from genetic interaction
12847083 MGI
acts upstream of or within leukocyte homeostasis IGI
IGI: Inferred from genetic interaction
11163212 MGI
acts upstream of or within limb morphogenesis IGI
IGI: Inferred from genetic interaction
11163212 MGI
acts upstream of or within mitochondrial fusion IGI
IGI: Inferred from genetic interaction
16893972 MGI
acts upstream of or within myeloid cell homeostasis IGI
IGI: Inferred from genetic interaction
15967824 MGI
acts upstream of or within negative regulation of endoplasmic reticulum calcium ion concentration IGI
IGI: Inferred from genetic interaction
15613488 MGI
acts upstream of or within negative regulation of peptidyl-serine phosphorylation IGI
IGI: Inferred from genetic interaction
15613488 MGI
acts upstream of peptidyl-serine phosphorylation IGI
IGI: Inferred from genetic interaction
15613488 MGI
acts upstream of or within positive regulation of apoptotic process IMP
IMP: Inferred from mutant phenotype
17068116 MGI
involved in positive regulation of apoptotic process IMP
IMP: Inferred from mutant phenotype
26949185 MGI
acts upstream of or within positive regulation of calcium ion transport into cytosol IGI
IGI: Inferred from genetic interaction
15613488 MGI
acts upstream of or within post-embryonic camera-type eye morphogenesis IGI
IGI: Inferred from genetic interaction
15955981 MGI
acts upstream of or within regulation of cell cycle IGI
IGI: Inferred from genetic interaction
16055554 MGI
involved in release of cytochrome c from mitochondria IMP
IMP: Inferred from mutant phenotype
10950869 MGI
acts upstream of or within response to fungus IMP
IMP: Inferred from mutant phenotype
16893972 MGI
acts upstream of or within response to gamma radiation IMP
IMP: Inferred from mutant phenotype
17068116 MGI
acts upstream of or within response to mycotoxin IMP
IMP: Inferred from mutant phenotype
16893972 MGI
acts upstream of or within thymocyte apoptotic process IGI
IGI: Inferred from genetic interaction
15967824 MGI
acts upstream of or within vagina development IGI
IGI: Inferred from genetic interaction
11163212 MGI
Cellular Component GO Annotation Evidence References Source
part of BAK complex IDA
IDA: Inferred from direct assay
10950869 MGI
part of BAK complex IPI
IPI: Inferred from physical interaction
27488021 MGI
located in cytosol IDA
IDA: Inferred from direct assay
12847083 MGI
located in endoplasmic reticulum IDA
IDA: Inferred from direct assay
12847083 MGI
located in intracellular anatomical structure IDA
IDA: Inferred from direct assay
11146504 MGI
located in mitochondrial membrane IDA
IDA: Inferred from direct assay
11980919 MGI
located in mitochondrial outer membrane IDA
IDA: Inferred from direct assay
10950869 MGI
located in mitochondrion IDA
IDA: Inferred from direct assay
12142566 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Bak1 Protein Structure

Bcl-2_like

Bcl-2_like: cd06845 (26 - 180)

  • 0
  • 100
  • 209 a.a.
Protein Preferred Names Protein Names

bcl-2 homologous antagonist/killer

  • Bcl2 homologous antagonist/killer

  • apoptosis regulator BAK

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (9)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-162858 BRD-810 98.00% Unkown
HY-129461 Dibenzyl trisulfide Inducer 98.24% Unkown
HY-183601 Mcl-1-IN-22 / Unkown
HY-E70788 BARK1 Recombinant Human Active Protein Kinase / Unkown
HY-RS01357 BAK1 Human Pre-designed siRNA Set A / Unkown
HY-RS01358 Bak1 Mouse Pre-designed siRNA Set A / Unkown
HY-RS01359 Bak1 Rat Pre-designed siRNA Set A / Unkown
HY-136999 7-O-Methyleucomol / Unkown
HY-174777 Human BAK1 mRNA / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Bak1 NCBI NCBI:578