Bcl2l11 - BCL2-like 11 (apoptosis facilitator) Gene

Also Known as Bim; Bod; bcl2-L-11; 1500006F24Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 12125

About Bcl2l11

Chromosome 2: 127,967,958-128,004,467 forward strand.GRCm39:CM000995.3

This gene has 8 transcripts (splice variants), 116 orthologues, 2 paralogues and is associated with 84 phenotypes. Ubiquitous expression in thymus adult (RPKM 7.8), lung adult (RPKM 4.3) and 28 other tissues.

Summary

Enables dynein complex binding activity; microtubule binding activity; and protein kinase binding activity. Involved in response to endoplasmic reticulum stress. Acts upstream of or within several processes, including animal organ development; apoptotic signaling pathway; and lymphocyte homeostasis. Located in mitochondrion. Is extrinsic component of membrane. Part of Bcl-2 Family protein complex. Is expressed in brain; hair outer root sheath; metanephros; spleen; and trunk unsegmented mesenchyme. Orthologous to human BCL2L11 (BCL2 like 11). [provided by Alliance of Genome Resources, Apr 2022]

Bcl2l11 Products (10)

mRNA Protein Name
NM_001406060.1 NP_001392989.1 bcl-2-like protein 11 isoform 6
NM_009754.3 NP_033884.1 bcl-2-like protein 11 isoform 3
NM_001291016.1 NP_001277945.1 bcl-2-like protein 11 isoform 5
NM_001406061.1 NP_001392990.1 bcl-2-like protein 11 isoform 7
NM_207680.2 NP_997563.1 bcl-2-like protein 11 isoform 1
NM_207681.2 NP_997564.1 bcl-2-like protein 11 isoform 2
NM_001406059.1 NP_001392988.1 bcl-2-like protein 11 isoform 6
NM_001406057.1 NP_001392986.1 bcl-2-like protein 11 isoform 2
NM_001284410.3 NP_001271339.2 bcl-2-like protein 11 isoform 4
NM_001406058.1 NP_001392987.1 bcl-2-like protein 11 isoform 3

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables microtubule binding IDA
IDA: Inferred from direct assay
16832056 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
14561217 MGI
enables protein kinase binding IPI
IPI: Inferred from physical interaction
20371704 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within B cell homeostasis IGI
IGI: Inferred from genetic interaction
15967824 MGI
acts upstream of or within B cell homeostasis IMP
IMP: Inferred from mutant phenotype
16055554 MGI
acts upstream of T cell apoptotic process IGI
IGI: Inferred from genetic interaction
16832056 MGI
acts upstream of T cell apoptotic process IMP
IMP: Inferred from mutant phenotype
16832056 MGI
acts upstream of or within T cell homeostasis IGI
IGI: Inferred from genetic interaction
17591857 MGI
acts upstream of or within T cell homeostasis IMP
IMP: Inferred from mutant phenotype
16270031 MGI
acts upstream of or within apoptotic process involved in embryonic digit morphogenesis IGI
IGI: Inferred from genetic interaction
15967824 MGI
acts upstream of cell cycle IMP
IMP: Inferred from mutant phenotype
17705137 MGI
acts upstream of or within cell-matrix adhesion IMP
IMP: Inferred from mutant phenotype
17276340 MGI
acts upstream of or within developmental pigmentation IGI
IGI: Inferred from genetic interaction
11709185 MGI
acts upstream of or within ear development IGI
IGI: Inferred from genetic interaction
11709185 MGI
acts upstream of or within extrinsic apoptotic signaling pathway in absence of ligand IGI
IGI: Inferred from genetic interaction
15967824 MGI
acts upstream of or within extrinsic apoptotic signaling pathway in absence of ligand IMP
IMP: Inferred from mutant phenotype
15967824 MGI
acts upstream of or within in utero embryonic development IGI
IGI: Inferred from genetic interaction
16282979 MGI
acts upstream of or within intrinsic apoptotic signaling pathway in response to DNA damage IGI
IGI: Inferred from genetic interaction
15967824 MGI
acts upstream of or within kidney development IGI
IGI: Inferred from genetic interaction
11709185 MGI
acts upstream of or within leukocyte homeostasis IGI
IGI: Inferred from genetic interaction
15967824 MGI
acts upstream of or within leukocyte homeostasis IMP
IMP: Inferred from mutant phenotype
15967824 MGI
acts upstream of lymphocyte apoptotic process IMP
IMP: Inferred from mutant phenotype
16270031 MGI
acts upstream of or within lymphocyte homeostasis IGI
IGI: Inferred from genetic interaction
11709185 MGI
acts upstream of or within lymphocyte homeostasis IMP
IMP: Inferred from mutant phenotype
11709185 MGI
acts upstream of or within male gonad development IGI
IGI: Inferred from genetic interaction
16270031 MGI
acts upstream of or within mammary gland development IMP
IMP: Inferred from mutant phenotype
17276340 MGI
acts upstream of or within myeloid cell homeostasis IGI
IGI: Inferred from genetic interaction
15967824 MGI
acts upstream of or within odontogenesis of dentin-containing tooth IGI
IGI: Inferred from genetic interaction
15967824 MGI
acts upstream of or within positive regulation of T cell apoptotic process IGI
IGI: Inferred from genetic interaction
16832056 MGI
acts upstream of or within positive regulation of T cell apoptotic process IMP
IMP: Inferred from mutant phenotype
16832056 MGI
acts upstream of or within positive regulation of apoptotic process IMP
IMP: Inferred from mutant phenotype
17276340 MGI
acts upstream of or within positive regulation of cell cycle IMP
IMP: Inferred from mutant phenotype
17705137 MGI
acts upstream of or within positive regulation of cysteine-type endopeptidase activity involved in apoptotic process IMP
IMP: Inferred from mutant phenotype
15967824 MGI
acts upstream of or within positive regulation of lymphocyte apoptotic process IMP
IMP: Inferred from mutant phenotype
16270031 MGI
acts upstream of or within positive regulation of mitochondrial membrane permeability involved in apoptotic process IGI
IGI: Inferred from genetic interaction
15967824 MGI
acts upstream of or within positive regulation of neuron apoptotic process IDA
IDA: Inferred from direct assay
15231831 MGI
acts upstream of or within post-embryonic development IGI
IGI: Inferred from genetic interaction
11709185 MGI
acts upstream of or within regulation of apoptotic process IGI
IGI: Inferred from genetic interaction
15818405 MGI
acts upstream of or within regulation of developmental pigmentation IGI
IGI: Inferred from genetic interaction
15818405 MGI
acts upstream of or within regulation of organ growth IMP
IMP: Inferred from mutant phenotype
17276340 MGI
involved in response to endoplasmic reticulum stress IDA
IDA: Inferred from direct assay
21159964 MGI
acts upstream of or within spermatogenesis IGI
IGI: Inferred from genetic interaction
16270031 MGI
acts upstream of or within spleen development IGI
IGI: Inferred from genetic interaction
15818405 MGI
acts upstream of or within symbiont-mediated activation of host apoptosis IDA
IDA: Inferred from direct assay
15231831 MGI
acts upstream of or within thymocyte apoptotic process IGI
IGI: Inferred from genetic interaction
15967824 MGI
acts upstream of or within thymus development IGI
IGI: Inferred from genetic interaction
15818405 MGI
acts upstream of or within tube formation IMP
IMP: Inferred from mutant phenotype
17276340 MGI
Cellular Component GO Annotation Evidence References Source
part of Bcl-2 family protein complex IMP
IMP: Inferred from mutant phenotype
16645638 MGI
located in cytoplasm IDA
IDA: Inferred from direct assay
15136728 MGI
located in intracellular membrane-bounded organelle IDA
IDA: Inferred from direct assay
15136728 MGI
located in membrane IDA
IDA: Inferred from direct assay
15136728 MGI
located in mitochondrion IDA
IDA: Inferred from direct assay
15136728 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Bcl2l11 Protein Structure

Bim_N

Bim_N: pfam06773 (3 - 39)

Bclx_interact

Bclx_interact: pfam08945 (128 - 163)

  • 0
  • 100
  • 196 a.a.
Protein Preferred Names Protein Names

bcl-2-like protein 11

  • Bcl2 interacting mediator of cell death

  • bcl2-interacting mediator of cell death

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-153953 Bcl-2-IN-11 Inhibitor / Unkown
HY-RS01427 BCL2L11 Human Pre-designed siRNA Set A / Unkown
HY-RS01428 Bcl2l11 Mouse Pre-designed siRNA Set A / Unkown
HY-RS01429 Bcl2l11 Rat Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Bcl2l11 NCBI NCBI:10018