Camk2b - calcium/calmodulin-dependent protein kinase II, beta Gene

Also Known as CaMKII

Species: Mus musculus

Gene Type: protein coding

Gene ID: 12323

Summary

Enables calmodulin-dependent protein kinase activity. Involved in regulation of neuron migration. Acts upstream of or within several processes, including activation of meiosis involved in egg activation; modulation of chemical synaptic transmission; and protein phosphorylation. Located in cytosol; postsynaptic density; and spindle midzone. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; sensory organ; and skeletal musculature. Human ortholog(s) of this gene implicated in autosomal dominant mental retardation 54. Orthologous to human CAMK2B (calcium/Calmodulin dependent protein kinase II beta). [provided by Alliance of Genome Resources, Apr 2022]

Camk2b Products (3)

mRNA	Protein	Name
NM_001174053.1	NP_001167524.1	calcium/calmodulin-dependent protein kinase type II subunit beta isoform 1
NM_001174054.1	NP_001167525.1	calcium/calmodulin-dependent protein kinase type II subunit beta isoform 3
NM_007595.5	NP_031621.3	calcium/calmodulin-dependent protein kinase type II subunit beta isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables calcium/calmodulin-dependent protein kinase activity	IDA IDA: Inferred from direct assay	9882483	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	22579289	MGI
enables protein serine/threonine kinase activity	IDA IDA: Inferred from direct assay	19332541	MGI
enables protein serine/threonine kinase activity	IMP IMP: Inferred from mutant phenotype	12660151	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within G1/S transition of mitotic cell cycle	IMP IMP: Inferred from mutant phenotype	12660151	MGI
acts upstream of or within activation of meiosis involved in egg activation	IMP IMP: Inferred from mutant phenotype	9882483	MGI
acts upstream of apoptotic signaling pathway	IDA IDA: Inferred from direct assay	17367784	MGI
acts upstream of or within calcium ion transport	IMP IMP: Inferred from mutant phenotype	12660151	MGI
acts upstream of or within inhibitory G protein-coupled receptor phosphorylation	IDA IDA: Inferred from direct assay	19332541	MGI
acts upstream of or within neuromuscular process controlling balance	IMP IMP: Inferred from mutant phenotype	19503086	MGI
acts upstream of or within peptidyl-serine phosphorylation	IDA IDA: Inferred from direct assay	19332541	MGI
acts upstream of or within positive regulation of apoptotic signaling pathway	IDA IDA: Inferred from direct assay	17367784	MGI
acts upstream of or within protein autophosphorylation	IMP IMP: Inferred from mutant phenotype	12660151	MGI
acts upstream of or within regulation of long-term neuronal synaptic plasticity	IMP IMP: Inferred from mutant phenotype	19503086	MGI
involved in regulation of neuron migration	IMP IMP: Inferred from mutant phenotype	29100089	MGI
acts upstream of or within regulation of synaptic transmission, cholinergic	IMP IMP: Inferred from mutant phenotype	19332541	MGI
acts upstream of or within response to cadmium ion	IDA IDA: Inferred from direct assay	17367784	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in cytosol	IDA IDA: Inferred from direct assay	9882483	MGI
located in postsynaptic density	IDA IDA: Inferred from direct assay	17114649	MGI
located in spindle midzone	IDA IDA: Inferred from direct assay	9882483	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
calcium/calmodulin-dependent protein kinase type II subunit beta	CaMK II caM kinase II subunit beta caMK-II subunit beta

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01857	CAMK2B Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS20531	Camk2b Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS27040	Camk2b Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Camk2b	NCBI	NCBI:816