Capn2 - calpain 2 Gene

Also Known as Capa2; CALP80; Capa-2; m-calpin; m-calpain

Species: Mus musculus

Gene Type: protein coding
Gene ID: 12334

Summary

Enables calcium-dependent cysteine-type endopeptidase activity. Involved in cellular response to amino acid stimulus and proteolysis. Acts upstream of or within blastocyst development and myoblast fusion. Located in several cellular components, including chromatin; cytosol; and lysosome. Is expressed in several structures, including hindbrain; lens epithelium; oral region epithelium; skin; and spinal cord floor plate. Orthologous to human CAPN2 (calpain 2). [provided by Alliance of Genome Resources, Apr 2022]

Capn2 Products (1)

mRNA Protein Name
NM_009794.4 NP_033924.2 calpain-2 catalytic subunit

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables calcium-dependent cysteine-type endopeptidase activity IDA
IDA: Inferred from direct assay
22555453 MGI
enables peptidase activity IDA
IDA: Inferred from direct assay
21849499 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within blastocyst development IMP
IMP: Inferred from mutant phenotype
16433929 MGI
involved in cellular response to amino acid stimulus IDA
IDA: Inferred from direct assay
22711986 MGI
acts upstream of or within myoblast fusion IMP
IMP: Inferred from mutant phenotype
10949052 MGI
involved in protein catabolic process at postsynapse EXP
EXP: Inferred from Experiment
20089917 MGI
involved in protein catabolic process at postsynapse IDA
IDA: Inferred from direct assay
20089917 MGI
involved in protein catabolic process at postsynapse IEP
IEP: Inferred from expression pattern
20089917 MGI
involved in protein catabolic process at postsynapse IMP
IMP: Inferred from mutant phenotype
20089917 MGI
involved in proteolysis IDA
IDA: Inferred from direct assay
22711986 MGI
involved in synaptic vesicle endocytosis EXP
EXP: Inferred from Experiment
35318705 MGI
involved in synaptic vesicle endocytosis IDA
IDA: Inferred from direct assay
35318705 MGI
involved in synaptic vesicle endocytosis IEP
IEP: Inferred from expression pattern
35318705 MGI
involved in synaptic vesicle endocytosis IMP
IMP: Inferred from mutant phenotype
35318705 MGI
Cellular Component GO Annotation Evidence References Source
located in chromatin IDA
IDA: Inferred from direct assay
18415939 MGI
located in cytoplasm IDA
IDA: Inferred from direct assay
18415939 MGI
located in cytosol IDA
IDA: Inferred from direct assay
22555453 MGI
located in lysosome IDA
IDA: Inferred from direct assay
22555453 MGI
located in nucleus IDA
IDA: Inferred from direct assay
18415939 MGI
is active in postsynapse IDA
IDA: Inferred from direct assay
20089917 MGI
is active in postsynapse IMP
IMP: Inferred from mutant phenotype
20089917 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

calpain-2 catalytic subunit

  • 80 kDa M-calpain subunit

  • CANP 2

  • calcium-activated neutral proteinase 2

  • calpain M-type

  • calpain-2 large subunit

  • cysteine proteinase

  • m-calpain 80 kDa large subunit

  • m-calpain large subunit

  • millimolar-calpain

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS01889 CAPN2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS01896 CAPNS2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18379 Capn2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24859 Capn2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Capn2 NCBI NCBI:824