Casp7 - caspase 7 Gene

Also Known as Mch3; CMH-1; mCASP-7; ICE-IAP3; caspase-7

Species: Mus musculus

Gene Type: protein coding
Gene ID: 12369

About Casp7

Chromosome 19: 56,385,561-56,430,776 forward strand.GRCm39:CM001012.3

This gene has 6 transcripts (splice variants), 218 orthologues, 11 paralogues and is associated with 1 phenotype.

Summary

Enables aspartic-type endopeptidase activity and cysteine-type endopeptidase activity involved in apoptotic process. Acts upstream of or within several processes, including execution phase of apoptosis; neuron apoptotic process; and response to UV. Predicted to be located in cytosol and nucleus. Predicted to be active in cytoplasm. Is expressed in brain; foregut; sensory organ; and urinary system. Human ortholog(s) of this gene implicated in Alzheimer's disease; breast cancer; colon cancer; and lung non-small cell carcinoma. Orthologous to human CASP7 (Caspase 7). [provided by Alliance of Genome Resources, Apr 2022]

Casp7 Products (1)

mRNA Protein Name
NM_007611.3 NP_031637.1 caspase-7 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables aspartic-type endopeptidase activity IDA
IDA: Inferred from direct assay
15231831 MGI
enables cysteine-type endopeptidase activity IDA
IDA: Inferred from direct assay
19759058 MGI
enables cysteine-type endopeptidase activity involved in apoptotic process IDA
IDA: Inferred from direct assay
16183742 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
19759058 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of defense response to bacterium IDA
IDA: Inferred from direct assay
35705808 MGI
acts upstream of or within execution phase of apoptosis IGI
IGI: Inferred from genetic interaction
16469926 MGI
acts upstream of or within fibroblast apoptotic process IGI
IGI: Inferred from genetic interaction
16469926 MGI
acts upstream of or within heart development IGI
IGI: Inferred from genetic interaction
16469926 MGI
involved in lymphocyte apoptotic process IMP
IMP: Inferred from mutant phenotype
19168786 MGI
acts upstream of or within neuron apoptotic process IDA
IDA: Inferred from direct assay
15231831 MGI
acts upstream of positive regulation of plasma membrane repair IDA
IDA: Inferred from direct assay
35705808 MGI
involved in protein maturation IDA
IDA: Inferred from direct assay
35705808 MGI
acts upstream of or within protein processing IDA
IDA: Inferred from direct assay
15231831 MGI
acts upstream of or within response to UV IGI
IGI: Inferred from genetic interaction
16469926 MGI
Cellular Component GO Annotation Evidence References Source
is active in extracellular space IDA
IDA: Inferred from direct assay
35705808 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

caspase-7

  • CASP-7

  • apoptotic protease Mch-3

  • cysteine protease LICE2

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-175177 XIAP-CASP7 PPI-IN-1 / Unkown
HY-RS01962 CASP7 Human Pre-designed siRNA Set A / Unkown
HY-RS01963 Casp7 Mouse Pre-designed siRNA Set A / Unkown
HY-RS01964 Casp7 Rat Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Casp7 NCBI NCBI:840