CASP7 - caspase 7 Gene

Also Known as MCH3; CMH-1; LICE2; CASP-7; ICE-LAP3

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 840

About CASP7

Cytogenetic location: 10q25.3 Genomic coordinates (GRCh38): 10:113,679,194-113,730,909 (from NCBI)

This gene has 13 transcripts (splice variants), 218 orthologues and 16 paralogues. Broad expression in colon (RPKM 28.2), small intestine (RPKM 22.7) and 25 other tissues.

Summary

This gene encodes a member of the cysteine-aspartic acid protease (Caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell Apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. The precursor of the encoded protein is cleaved by Caspase 3 and 10, is activated upon cell death stimuli and induces Apoptosis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, May 2012]

CASP7 Products (11)

mRNA	Protein	Name
XM_006718017.4	XP_006718080.1	caspase-7 isoform X2
NM_001227.5	NP_001218.1	caspase-7 isoform alpha precursor
NM_033338.6	NP_203124.1	caspase-7 isoform delta
NM_033340.4	NP_203126.1	caspase-7 isoform beta
XM_011540260.2	XP_011538562.1	caspase-7 isoform X3
NM_001267058.2	NP_001253987.1	caspase-7 isoform f
NM_033339.5	NP_203125.1	caspase-7 isoform alpha precursor
NM_001267057.1	NP_001253986.1	caspase-7 isoform e
XM_017016763.2	XP_016872252.1	caspase-7 isoform X1
NM_001267056.2	NP_001253985.1	caspase-7 isoform alpha precursor
NM_001320911.2	NP_001307840.1	caspase-7 isoform g

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables RNA binding	IDA IDA: Inferred from direct assay	31586028	GOA
enables cysteine-type endopeptidase activity	IDA IDA: Inferred from direct assay	17646170	GOA
enables cysteine-type endopeptidase activity involved in apoptotic process	IDA IDA: Inferred from direct assay	11257230	GOA
enables cysteine-type endopeptidase activity involved in execution phase of apoptosis	IDA IDA: Inferred from direct assay	16123041	GOA
enables cysteine-type endopeptidase activity involved in execution phase of apoptosis	IMP IMP: Inferred from mutant phenotype	22253444	GOA
enables peptidase activity	IDA IDA: Inferred from direct assay	19740745	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	11084335	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in apoptotic process	IDA IDA: Inferred from direct assay	17464193	GOA
involved in cellular response to lipopolysaccharide	IDA IDA: Inferred from direct assay	22464733	GOA
involved in cellular response to staurosporine	IMP IMP: Inferred from mutant phenotype	22253444	GOA
involved in execution phase of apoptosis	IDA IDA: Inferred from direct assay	16374543	GOA
involved in protein catabolic process	IDA IDA: Inferred from direct assay	16374543	GOA
involved in protein maturation	IDA IDA: Inferred from direct assay	21157428	GOA
involved in proteolysis	IDA IDA: Inferred from direct assay	12888622	GOA

Cellular Component GO Annotation	Evidence	References	Source
is active in cytoplasm	IDA IDA: Inferred from direct assay	21555521	GOA
is active in cytosol	IDA IDA: Inferred from direct assay	16352606	GOA
located in cytosol	IDA IDA: Inferred from direct assay	17167422	GOA
is active in nucleus	IDA IDA: Inferred from direct assay	16374543	GOA
located in nucleus	IDA IDA: Inferred from direct assay	17167422	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CASP7 Protein Structure

Peptidase_C14

0
100
200
303 a.a.

Protein Preferred Names	Protein Names
caspase-7	ICE-like apoptotic protease 3 apoptotic protease MCH-3 caspase 7, apoptosis-related cysteine peptidase caspase 7, apoptosis-related cysteine protease

CASP7 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	CASP7	P55210	PAK2	Homo sapiens	Q13177	Protein Kinase Assay	21555521
Intra	CASP7	P55210	KLHL36	Homo sapiens	Q8N4N3-2	Validated Y2H	32814053
Intra	CASP7	P55210	KLHL36	Homo sapiens	Q8N4N3-2	Y2H Pooling	32814053
Intra	CASP7	P55210	KLHL36	Homo sapiens	Q8N4N3-2	Y2H Array	32814053
Intra	CASP7	P55210	HTRA4	Homo sapiens	P83105	Protease Assay	31470122
Intra	CASP7	P55210	BIRC2	Homo sapiens	Q13490	Enzymatic Study	11084335
Intra	CASP7	P55210	BIRC2	Homo sapiens	Q13490	Pull Down	11084335
Intra	CASP7	P55210	BIRC2	Homo sapiens	Q13490	Anti Tag CoIP	33961781
Intra	CASP7	P55210	XIAP	Homo sapiens	P98170	Pull Down	9525868
Intra	CASP7	P55210	XIAP	Homo sapiens	P98170	X-Ray Diffraction	11257230
Intra	CASP7	P55210	XIAP	Homo sapiens	P98170	Anti Tag CoIP	33961781
Intra	CASP7	P55210	XIAP	Homo sapiens	P98170	X-Ray Diffraction	11257231
Intra	CASP7	P55210	SMPD1	Homo sapiens	P17405	IF	21157428
Intra	CASP7	P55210	SMPD1	Homo sapiens	P17405	Anti Bait CoIP	21157428
Intra	CASP7	P55210	SAT1	Homo sapiens	P21673	Y2H Array	25416956
Intra	CASP7	P55210	SAT1	Homo sapiens	P21673	Y2H Prey Pooling	32296183
Intra	CASP7	P55210	SAT1	Homo sapiens	P21673	Y2H Array	32296183
Intra	CASP7	P55210	MAGEA11	Homo sapiens	P43364	Y2H Prey Pooling	32296183
Intra	CASP7	P55210	MAGEA11	Homo sapiens	P43364	Y2H Array	32296183
Intra	CASP7	P55210	NIF3L1	Homo sapiens	Q9GZT8	Validated Y2H	32296183
Intra	CASP7	P55210	NIF3L1	Homo sapiens	Q9GZT8	Y2H Array	32296183
Intra	CASP7	P55210	NIF3L1	Homo sapiens	Q9GZT8	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant CASP7 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P74347	Caspase-7/CASP7 Protein, Human (His)	P55210 (M1-Q303)	≥ 90%, as determined by reducing SDS-PAGE.

CASP7 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P80589	Caspase-7 Antibody (YA561)	WB, ICC/IF, IP	Mouse, Rat
HY-P80589A	Caspase-7 Antibody (YA561)(PBS only)	WB, ICC/IF, IP	Mouse, Rat
HY-P84402	Caspase-7 Antibody (YA4099)	WB, IHC-P, FC, ELISA	Human
HY-P84402A	Caspase-7 Antibody (YA4099)(PBS only)	WB, IHC-P, FC, ELISA	Human
HY-P86072	Cleaved Caspase-7 (Asp198) Antibody (YA5764)	WB, ICC/IF, IP, ELISA	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Hepatocellular Carcinoma	Liver Cancer Primary Liver Cancer HCC Hepatoma Malignant Neoplasm Of Liver Liver Neoplasms Cancer, Hepatocellular Liver Cell Carcinoma Lcc Hepatoblastoma, Somatic Hepatic Cancer Primary Malignant Neoplasm Of Liver Rare Tumor Of Liver And Intrahepatic Biliary Tract Hepatocellular Carcinoma, Somatic Hepatocellular Carcinoma, Childhood Type, Somatic Hepatocellular Cancer, Somatic Ca Liver - Primary Hepatic Neoplasm Malignant Hepato-Biliary Neoplasm Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary Malignant Neoplasm Of Liver, Primary Malignant Tumor Of Liver Neoplasm Of Liver Non-Resectable Primary Hepatic Malignant Neoplasm Resectable Malignant Neoplasm Of Liver Resectable Malignant Neoplasm Of The Liver Primary Liver Carcinoma Primary Malignant Liver Neoplasm Primary Cancer Of Liver Primary Tumor Of The Liver Rare Tumor Of Liver And Ibt Hepatocellular Cancer Neoplasm Of The Liver Hepatomas Liver Neoplasm Liver Carcinoma Liver And Intrahepatic Biliary Tract Carcinoma Malignant Hepatobiliary Neoplasm Adult Primary Hepatocellular Carcinoma Hepatoblastoma Carcinoma Of Liver Malignant Liver Tumour Malignant Hepatic Tumour
Colorectal Cancer	Colon Cancer Colorectal Carcinoma Colon Carcinoma Colorectal Cancer, Susceptibility To Carcinoma Of Colon CRC Colorectal Cancer With Chromosomal Instability, Somatic Colon Cancer, Somatic Colon Cancer, Susceptibility To Colonic Neoplasms Colorectal Neoplasms Colorectal Cancer, Somatic Colon Cancer, Advanced, Somatic Colonic Carcinoma Colorectal Carcinomas Colon Cancers Colorectal Cancers Cancer, Colorectal, Somatic Cancer, Colon Cancer, Colorectal, Susceptibility To Colorectal Neoplasm Colonic Neoplasm Malignant Tumor Of Colon
Breast Cancer	Breast Carcinoma Breast Cancer, Familial Malignant Neoplasm Of Breast Male Breast Cancer Breast Cancer, Susceptibility To Breast Cancer, Early-Onset Malignant Tumor Of Breast Carcinoma Of Male Breast Breast Cancer, Invasive Ductal Breast Cancer, Protection Against Breast Cancer, Somatic Breast Cancer, Male Breast Cancer, Lobular, Somatic Breast Tumor Mammary Cancer Mammary Tumor Malignant Neoplasm Of Male Breast Mammary Carcinoma Male Breast Carcinoma Familial Cancer Of Breast Invasive Ductal Breast Carcinoma Breast Cancer Susceptibility Breast Cancer, Male, Susceptibility To Breast Cancer, Early-Onset, Susceptibility To Malignant Tumor Of The Breast Mammary Neoplasm Primary Breast Cancer Neoplasm Of Male Breast Carcinoma Of Breast Breast Cancer In Men Familial Breast Cancer Cancer Of Breast BC Breast Cancer Familial Breast Cancer Familial Male Breast Cancer, Familial Male Breast Male Carcinoma Breast Neoplasms Breast Neoplasms, Male Mammary Tumors Mammary Carcinomas Cancer, Breast Cancer, Breast, Susceptibility Invasive Breast Ductal Carcinoma Breast Neoplasm Susceptibility To Breast Cancer Mammary Neoplasms Animal Mammary Neoplasms Primary Malignant Neoplasm Of Breast Infiltrating Ductal Carcinoma Of Breast Infiltrating Duct Carcinoma Of Unspecified Site Infiltrating Ductular Carcinoma Of Unspecified Site Invasive Breast Carcinoma Of No Special Type Microinvasive Carcinoma Of Breast Carcinoma With Apocrine Differentiation
Prostate Cancer	Prostate Carcinoma Prostate Cancer, Familial Prostate Neoplasm Prostate Cancer, Somatic Prostate Cancer, Susceptibility To Prostatic Cancer Prostatic Neoplasms Hereditary Prostate Cancer Prostatic Neoplasm Cancer Of Prostate Carcinoma Of Prostate Familial Prostate Cancer Familial Prostate Carcinoma Malignant Tumor Of Prostate Malignant Neoplasm Of Prostate Prostate Cancer, Familial, Susceptibility To Malignant Tumor Of The Prostate Ngp - New Growth Of Prostate Tumor Of The Prostate Prostate Cancer, Hereditary Cancer Of The Prostate Malignant Neoplasm Of The Prostate Prostatic Carcinoma PC Prca Cancer, Prostate Malignant Prostatic Tumour Malignant Tumour Of Prostate Primary Prostate Cancer Primary Malignant Neoplasm Of Prostate Prostate Gland Cancer
Ovarian Cancer	Ovarian Carcinoma Ovarian Neoplasm Malignant Tumour Of Ovary Epithelial Ovarian Cancer Neoplasm Of Ovary Ovarian Neoplasms Ovarian Cancers Malignant Neoplasm Of Ovary Primary Malignant Neoplasm Of Ovary Ovarian Cancer, Somatic Malignant Ovarian Tumor Ovary Neoplasm Primary Ovarian Cancer Tumor Of The Ovary Cancer Of The Ovary Malignant Neoplasm Of The Ovary Malignant Tumor Of The Ovary Ovarian Malignant Tumor OC Ovarian Carcinomas Cancer, Ovarian Cancer Of Ovary Ovary Cancer Ca Ovary
Lymphoma, Non-Hodgkin, Familial	Non-Hodgkin Lymphoma Lymphoma, Non-Hodgkin NHL Lymphoma, Non-Hodgkin, Somatic Lymphoma, Follicular, Somatic Familial Non-Hodgkin Lymphoma Lymphoma Non-Hodgkins Follicular Lymphoma, Somatic Lymphosarcoma Non-Hodgkins Lymphoma
Robinow Syndrome, Autosomal Dominant 3	Autosomal Dominant Robinow Syndrome 3 DRS3 Robinow, Autosomal Dominant Syndrome, Type 3
Pancreatic Cancer	Pancreatic Carcinoma Familial Pancreatic Carcinoma Pancreatic Neoplasm Carcinoma Of Pancreas Pancreatic Carcinoma, Familial Malignant Neoplasm Of Pancreas Pancreatic Acinar Carcinoma Pancreatic Tumor Familial Pancreatic Cancer Neoplasm Of The Pancreas Pancreatic Carcinoma, Somatic Pancreatic Cancer, Somatic Ca Body Of Pancreas Ca Head Of Pancreas Ca Tail Of Pancreas Malignant Neoplasm Of Body Of Pancreas Malignant Neoplasm Of Head Of Pancreas Malignant Neoplasm Of Tail Of Pancreas Pancreas Neoplasm Exocrine Cancer Exocrine Pancreas Carcinoma Hereditary Pancreatic Cancer Hereditary Pancreatic Carcinoma PNCA Cancer Of The Pancreas Pancreatic Cancer, Susceptibility To Carcinoma Of Head Of Pancreas Pancreatic Neoplasms Pancreatic Tumors Cancer, Pancreatic Cancer Of Pancreas Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site
Type 1 Diabetes Mellitus 17	Diabetes Mellitus, Insulin-Dependent, 17 Iddm17 Insulin-Dependent Diabetes Mellitus 17 TID17 Insulin-Dependent Diabetes Mellitus-17
Acute Laryngopharyngitis	Pharyngolaryngitis Laryngopharyngitis Hypopharyngitis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Purity	Rare Diseases
HY-175177	XIAP-CASP7 PPI-IN-1	/	Unkown
HY-RS01962	CASP7 Human Pre-designed siRNA Set A	/	Unkown
HY-RS01963	Casp7 Mouse Pre-designed siRNA Set A	/	Unkown
HY-RS01964	Casp7 Rat Pre-designed siRNA Set A	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	CASP7	VGNC	VGNC:26783
Mus musculus	CASP7	MGD	MGI:109383
Macaca mulatta	CASP7	VGNC	VGNC:70546
Rattus norvegicus	CASP7	RGD	RGD:620944
Canis familiaris	CASP7	VGNC	VGNC:38735
Felis catus	CASP7	VGNC	VGNC:60383
Others	CASP7	NCBI