OSCAR - osteoclast associated Ig-like receptor Gene

Also Known as PIGR3; PIgR-3

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 126014

About OSCAR

Cytogenetic location: 19q13.42 Genomic coordinates (GRCh38): 19:54,094,668-54,100,803 (from NCBI)

This gene has 10 transcripts (splice variants), 1 gene allele, 224 orthologues and 25 paralogues. Biased expression in lung (RPKM 7.4), bone marrow (RPKM 7.3) and 12 other tissues.

Summary

Osteoclasts are multinucleated cells that resorb bone and are essential for bone homeostasis. This gene encodes an osteoclast-associated receptor (OSCAR), which is a member of the leukocyte receptor complex protein family that plays critical roles in the regulation of both innate and adaptive immune responses. The encoded protein may play a role in oxidative stress-mediated atherogenesis as well as monocyte adhesion. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2013]

OSCAR Products (6)

mRNA Protein Name
NM_001282349.3 NP_001269278.1 osteoclast-associated immunoglobulin-like receptor isoform 6 precursor
NM_001282350.3 NP_001269279.1 osteoclast-associated immunoglobulin-like receptor isoform 7 precursor
NM_130771.6 NP_570127.3 osteoclast-associated immunoglobulin-like receptor isoform 3 precursor
NM_133168.6 NP_573398.2 osteoclast-associated immunoglobulin-like receptor isoform 5 precursor
NM_133169.6 NP_573399.2 osteoclast-associated immunoglobulin-like receptor isoform 4 precursor
NM_206818.4 NP_996554.2 osteoclast-associated immunoglobulin-like receptor isoform 1 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables collagen receptor activity IDA
IDA: Inferred from direct assay
21841309 GOA
enables collagen receptor activity IMP
IMP: Inferred from mutant phenotype
21841309 GOA
Biological Process GO Annotation Evidence References Source
acts upstream of or within osteoclast differentiation IMP
IMP: Inferred from mutant phenotype
21841309 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

OSCAR Protein Structure

Ig_2

Ig_2: Immunoglobulin domain (36 - 127)

Ig_2

Ig_2: Immunoglobulin domain (134 - 205)

  • 0
  • 100
  • 200
  • 286 a.a.
Protein Preferred Names Protein Names

osteoclast-associated immunoglobulin-like receptor

  • osteoclast associated receptor OSCAR-S1

Recombinant OSCAR Proteins

Cat. No. Product Name Accession Purity
HY-P78011 OSCAR Protein, Human (HEK293, Fc) Q8IYS5-2 (D19-N229) ≥ 95%, as determined by Bis-Tris PAGE.

Related Diseases

Diseases Alias
Microphthalmia

  • Microphthalmos

  • Isolated Anophthalmia-Microphthalmia Syndrome

  • Isolated Microphthalmia-Anophthalmia-Coloboma

  • Simple Microphthalmos

  • Clinical Anophthalmia

  • Isolated Anophthalmia - Microphthalmia

  • Isolated Pure Microphthalmia

  • Mac Spectrum

  • Microphthalmia-Anophthalmia-Coloboma Spectrum

  • Primitive Anophthalmia

  • Globe Of Eye Small

  • Small Eyeball

  • Hypoplasia Of Eye

  • Isolated Nanophthalmos

  • Rudimentary Eye

  • Dysplasia Of Eye
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS09847 OSCAR Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19466 Oscar Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25959 Oscar Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P992285 Anti-OSCAR Antibody / Unkown