Cer1 - cerberus 1, DAN family BMP antagonist Gene

Also Known as Cerl; Cerl1; Cerr1; cer-1

Species: Mus musculus

Gene Type: protein coding
Gene ID: 12622

Summary

Enables protein homodimerization activity. Involved in negative regulation of mesoderm development; negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway; and ureteric bud development. Acts upstream of or within several processes, including cellular response to cadmium ion; growth plate cartilage chondrocyte proliferation; and signal transduction involved in regulation of gene expression. Located in extracellular space. Is expressed in several structures, including alimentary system; brain; genitourinary system; paraxial mesenchyme; and sensory organ. Orthologous to human CER1 (cerberus 1, Dan family BMP antagonist). [provided by Alliance of Genome Resources, Apr 2022]

Cer1 Products (1)

mRNA Protein Name
NM_009887.2 NP_034017.1 cerberus precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein homodimerization activity IDA
IDA: Inferred from direct assay
10748465 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within anterior/posterior axis specification IDA
IDA: Inferred from direct assay
15004567 MGI
acts upstream of or within anterior/posterior axis specification IGI
IGI: Inferred from genetic interaction
15004567 MGI
acts upstream of or within anterior/posterior pattern specification IDA
IDA: Inferred from direct assay
9501024 MGI
acts upstream of or within cell migration involved in gastrulation IGI
IGI: Inferred from genetic interaction
15004567 MGI
acts upstream of cell population proliferation IGI
IGI: Inferred from genetic interaction
15004567 MGI
acts upstream of or within cellular response to cadmium ion IDA
IDA: Inferred from direct assay
15219627 MGI
acts upstream of or within gastrulation IGI
IGI: Inferred from genetic interaction
18241853 MGI
involved in growth plate cartilage chondrocyte proliferation IEP
IEP: Inferred from expression pattern
19113921 MGI
acts upstream of or within negative regulation of BMP signaling pathway IDA
IDA: Inferred from direct assay
9431803 MGI
NOT involved in negative regulation of Wnt signaling pathway IDA
IDA: Inferred from direct assay
10748465 MGI
involved in negative regulation of activin receptor signaling pathway IDA
IDA: Inferred from direct assay
10748465 MGI
acts upstream of or within negative regulation of cell population proliferation IGI
IGI: Inferred from genetic interaction
15004567 MGI
involved in negative regulation of mesoderm development IDA
IDA: Inferred from direct assay
10748465 MGI
involved in sequestering of BMP in extracellular matrix IDA
IDA: Inferred from direct assay
10748465 MGI
acts upstream of or within signal transduction involved in regulation of gene expression IDA
IDA: Inferred from direct assay
18462699 MGI
involved in ureteric bud development IMP
IMP: Inferred from mutant phenotype
22114682 MGI
Cellular Component GO Annotation Evidence References Source
located in extracellular region IDA
IDA: Inferred from direct assay
9431803 MGI
located in extracellular space IDA
IDA: Inferred from direct assay
10748465 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

cerberus

  • cer-l

  • cerberus 1 homolog

  • cerberus homolog

  • cerberus-like protein

  • cerberus-related protein

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (13)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-126015 P053 Inhibitor 97.0% Unkown
HY-120803 Mefluidide 99.81% Unkown
HY-146910S CER1 (d18:1/26:0/18:1)-d9 99.0% Unkown
HY-176568 LCL768 / Unkown
HY-N15835 CER1(d18:1/28:0/18:2) / Unkown
HY-RS02532 CER1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS02536 CERS1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-175198 Cs-2d Inhibitor / Unkown
HY-179832 CER1 (d18:1/26:0/18:1) / Unkown
HY-RS18128 Cer1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19995 Cers1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24602 Cer1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26499 Cers1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Cer1 NCBI NCBI:9350