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Coro1a - coronin, actin binding protein 1A Gene

Also Known as p57; Lmb3; TACO; Clabp

Species: Mus musculus

Gene Type: protein coding

Gene ID: 12721

Summary

This gene encodes a member of the WD repeat coronin family. The encoded protein may bind actin and interact with microtubules. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2014]

Coro1a Products (4)

mRNA	Protein	Name
NM_001301374.2	NP_001288303.1	coronin-1A
NM_001412247.1	NP_001399176.1	coronin-1A
NM_001412248.1	NP_001399177.1	coronin-1A
NM_009898.4	NP_034028.1	coronin-1A

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables actin filament binding	IDA IDA: Inferred from direct assay	18836449	MGI
enables cytoskeletal protein binding	IMP IMP: Inferred from mutant phenotype	15800061	MGI
enables identical protein binding	IPI IPI: Inferred from physical interaction	15800061	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	18836449	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of T cell activation	IMP IMP: Inferred from mutant phenotype	18199416	MGI
acts upstream of or within T cell homeostasis	IMP IMP: Inferred from mutant phenotype	16902139	MGI
acts upstream of T cell migration	IMP IMP: Inferred from mutant phenotype	18199416	MGI
acts upstream of T cell proliferation	IMP IMP: Inferred from mutant phenotype	18199416	MGI
acts upstream of or within actin filament organization	IMP IMP: Inferred from mutant phenotype	18199416	MGI
acts upstream of or within calcium ion transport	IMP IMP: Inferred from mutant phenotype	18199416	MGI
acts upstream of or within cellular response to interleukin-4	IDA IDA: Inferred from direct assay	9798653	MGI
acts upstream of or within early endosome to recycling endosome transport	IMP IMP: Inferred from mutant phenotype	24270184	MGI
acts upstream of or within epithelial cell migration	IMP IMP: Inferred from mutant phenotype	16902139	MGI
acts upstream of or within establishment of localization in cell	IMP IMP: Inferred from mutant phenotype	18199416	MGI
acts upstream of or within homeostasis of number of cells within a tissue	IMP IMP: Inferred from mutant phenotype	18836449	MGI
acts upstream of or within leukocyte chemotaxis	IMP IMP: Inferred from mutant phenotype	16902139	MGI
acts upstream of or within negative regulation of neuron apoptotic process	IGI IGI: Inferred from genetic interaction	24270184	MGI
acts upstream of or within negative regulation of vesicle fusion	IMP IMP: Inferred from mutant phenotype	24270184	MGI
acts upstream of or within nerve growth factor signaling pathway	IGI IGI: Inferred from genetic interaction	24270184	MGI
acts upstream of neuron apoptotic process	IGI IGI: Inferred from genetic interaction	24270184	MGI
acts upstream of or within positive regulation of T cell activation	IMP IMP: Inferred from mutant phenotype	18199416	MGI
acts upstream of or within positive regulation of T cell migration	IMP IMP: Inferred from mutant phenotype	18199416	MGI
acts upstream of or within positive regulation of T cell proliferation	IMP IMP: Inferred from mutant phenotype	18199416	MGI
acts upstream of or within regulation of actin filament polymerization	IMP IMP: Inferred from mutant phenotype	18836449	MGI
acts upstream of or within regulation of actin polymerization or depolymerization	IMP IMP: Inferred from mutant phenotype	16902139	MGI
acts upstream of or within regulation of cell shape	IMP IMP: Inferred from mutant phenotype	18836449	MGI
acts upstream of or within regulation of release of sequestered calcium ion into cytosol	IGI IGI: Inferred from genetic interaction	24270184	MGI
acts upstream of or within response to cytokine	IMP IMP: Inferred from mutant phenotype	18836449	MGI
acts upstream of or within thymocyte migration	IMP IMP: Inferred from mutant phenotype	18836449	MGI
acts upstream of or within uropod organization	IMP IMP: Inferred from mutant phenotype	16902139	MGI
acts upstream of vesicle fusion	IMP IMP: Inferred from mutant phenotype	24270184	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in actin cytoskeleton	IDA IDA: Inferred from direct assay	15800061	MGI
located in axon	IDA IDA: Inferred from direct assay	24270184	MGI
located in cell leading edge	IDA IDA: Inferred from direct assay	18836449	MGI
located in cell-cell junction	IDA IDA: Inferred from direct assay	23793062	MGI
located in early endosome	IDA IDA: Inferred from direct assay	24270184	MGI
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	24667537	MGI
located in immunological synapse	IDA IDA: Inferred from direct assay	18199416	MGI
located in plasma membrane	IDA IDA: Inferred from direct assay	15800061	MGI
is active in stereocilium tip	EXP EXP: Inferred from Experiment	26754646	MGI
is active in synapse	IDA IDA: Inferred from direct assay	24667537	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
coronin-1A	clipin-A coronin 1 coronin-like actin binding protein coronin-like protein A coronin-like protein p57 tryptophan aspartate-containing coat protein

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03048	CORO1A Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21841	Coro1a Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS28357	Coro1a Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Coro1a	NCBI	NCBI:11151