Cldn4 - claudin 4 Gene

Also Known as Cep-r; Cpetr; Cpetr1

Species: Mus musculus

Gene Type: protein coding
Gene ID: 12740

Summary

This gene encodes a member of the Claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. The protein encoded by this gene is a high-affinity receptor for clostridium perfringens enterotoxin (CPE) produced by the bacterium Clostridium perfringens, and the interaction with CPE results in increased membrane permeability by forming small pores in plasma membrane. This protein augments alveolar epithelial barrier function and is induced in acute lung injury. It is highly expressed in pancreatic and ovarian cancers. [provided by RefSeq, Aug 2010]

Cldn4 Products (1)

mRNA Protein Name
NM_009903.2 NP_034033.1 claudin-4

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
10601346 MGI
Biological Process GO Annotation Evidence References Source
involved in paracellular transport IMP
IMP: Inferred from mutant phenotype
20921420 MGI
involved in renal absorption IMP
IMP: Inferred from mutant phenotype
20921420 MGI
Cellular Component GO Annotation Evidence References Source
located in apicolateral plasma membrane IDA
IDA: Inferred from direct assay
9892664 MGI
located in bicellular tight junction IDA
IDA: Inferred from direct assay
9892664 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
15775979 MGI
located in tight junction IDA
IDA: Inferred from direct assay
30734065 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

claudin-4

  • CPE-R

  • CPE-receptor

  • clostridium perfringens enterotoxin receptor

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS02772 CLDN4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-P11785 Cpe30 MT2 Ligand / Unkown
HY-RS21532 Cldn4 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28050 Cldn4 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Cldn4 NCBI NCBI:1364