CLDN4 - claudin 4 Gene

Also Known as CPER; CPE-R; CPETR; CPETR1; WBSCR8; hCPE-R

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 1364

About CLDN4

Cytogenetic location: 7q11.23 Genomic coordinates (GRCh38): 7:73,830,996-73,832,690 (from NCBI)

This gene has 5 transcripts (splice variants), 339 orthologues and 22 paralogues.

Summary

The protein encoded by this intronless gene belongs to the Claudin family. Claudins are integral membrane proteins that are components of the epithelial cell tight junctions, which regulate movement of solutes and ions through the paracellular space. This protein is a high-affinity receptor for Clostridium perfringens enterotoxin (CPE) and may play a role in internal organ development and function during pre- and postnatal life. This gene is deleted in Williams-Beuren syndrome, a neurodevelopmental disorder affecting multiple systems. [provided by RefSeq, Sep 2013]

CLDN4 Products (1)

mRNA Protein Name
NM_001305.5 NP_001296.1 claudin-4

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
27647526 GOA
Biological Process GO Annotation Evidence References Source
involved in establishment of skin barrier IMP
IMP: Inferred from mutant phenotype
23407391 GOA
involved in positive regulation of cell migration IMP
IMP: Inferred from mutant phenotype
16103090 GOA
involved in positive regulation of metallopeptidase activity IMP
IMP: Inferred from mutant phenotype
16103090 GOA
involved in positive regulation of wound healing IMP
IMP: Inferred from mutant phenotype
16103090 GOA
involved in regulation of cell morphogenesis IMP
IMP: Inferred from mutant phenotype
16103090 GOA
Cellular Component GO Annotation Evidence References Source
located in bicellular tight junction IDA
IDA: Inferred from direct assay
23407391 GOA
located in cell-cell junction IDA
IDA: Inferred from direct assay
18774778 GOA
located in plasma membrane IDA
IDA: Inferred from direct assay
20375010 GOA
located in plasma membrane IMP
IMP: Inferred from mutant phenotype
23407391 GOA
located in tight junction IDA
IDA: Inferred from direct assay
30734065 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CLDN4 Protein Structure

PMP22_Claudin

PMP22_Claudin: PMP-22/EMP/MP20/Claudin family (4 - 180)

  • 0
  • 100
  • 209 a.a.
Protein Preferred Names Protein Names

claudin-4

  • CPE-receptor

CLDN4 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
CLDN4 O14493 TRIM59 Homo sapiens Q8IWR1
Validated Y2H
32296183
Intra
CLDN4 O14493 TRIM59 Homo sapiens Q8IWR1
Y2H Array
32296183
Intra
CLDN4 O14493 TRIM59 Homo sapiens Q8IWR1
Y2H Prey Pooling
32296183
Intra
CLDN4 O14493 TMEM237 Homo sapiens Q96Q45-2
Y2H Prey Pooling
32296183
Intra
CLDN4 O14493 TMEM237 Homo sapiens Q96Q45-2
Validated Y2H
32296183
Intra
CLDN4 O14493 TMEM237 Homo sapiens Q96Q45-2
Y2H Array
32296183
Intra
CLDN4 O14493 ARL13B Homo sapiens Q3SXY8
Y2H Prey Pooling
32296183
Intra
CLDN4 O14493 ARL13B Homo sapiens Q3SXY8
Validated Y2H
32296183
Intra
CLDN4 O14493 ARL13B Homo sapiens Q3SXY8
Y2H Array
32296183
Intra
CLDN4 O14493 TSPO2 Homo sapiens Q5TGU0
Y2H Prey Pooling
32296183
Intra
CLDN4 O14493 TSPO2 Homo sapiens Q5TGU0
Validated Y2H
32296183
Intra
CLDN4 O14493 TSPO2 Homo sapiens Q5TGU0
Y2H Array
32296183
Intra
CLDN4 O14493 AQP6 Homo sapiens Q13520
Y2H Prey Pooling
32296183
Intra
CLDN4 O14493 AQP6 Homo sapiens Q13520
Validated Y2H
32296183
Intra
CLDN4 O14493 AQP6 Homo sapiens Q13520
Y2H Array
32296183
Intra
CLDN4 O14493 GJA8 Homo sapiens P48165
Validated Y2H
32296183
Intra
CLDN4 O14493 GJA8 Homo sapiens P48165
Y2H Prey Pooling
32296183
Intra
CLDN4 O14493 GJA8 Homo sapiens P48165
Y2H Array
32296183
Intra
CLDN4 O14493 CLEC14A Homo sapiens Q86T13
Y2H Array
32296183
Intra
CLDN4 O14493 CLEC14A Homo sapiens Q86T13
Y2H Prey Pooling
32296183
Intra
CLDN4 O14493 CLEC14A Homo sapiens Q86T13
Validated Y2H
32296183
Intra
CLDN4 O14493 HSD17B13 Homo sapiens Q7Z5P4
Y2H Array
32296183
Intra
CLDN4 O14493 HSD17B13 Homo sapiens Q7Z5P4
Validated Y2H
32296183
Intra
CLDN4 O14493 HSD17B13 Homo sapiens Q7Z5P4
Y2H Prey Pooling
32296183
Intra
CLDN4 O14493 TMEM52B Homo sapiens Q4KMG9
Validated Y2H
32296183
Intra
CLDN4 O14493 TMEM52B Homo sapiens Q4KMG9
Y2H Array
32296183
Intra
CLDN4 O14493 TMEM52B Homo sapiens Q4KMG9
Y2H Prey Pooling
32296183
Intra
CLDN4 O14493 FAM209A Homo sapiens Q5JX71
Y2H Prey Pooling
32296183
Intra
CLDN4 O14493 FAM209A Homo sapiens Q5JX71
Validated Y2H
32296183
Intra
CLDN4 O14493 FAM209A Homo sapiens Q5JX71
Y2H Array
32296183
Intra
CLDN4 O14493 FFAR2 Homo sapiens O15552
Validated Y2H
32296183
Intra
CLDN4 O14493 FFAR2 Homo sapiens O15552
Y2H Prey Pooling
32296183
Intra
CLDN4 O14493 FFAR2 Homo sapiens O15552
Y2H Array
32296183
Intra
CLDN4 O14493 MFSD14B Homo sapiens Q5SR56
Validated Y2H
32296183
Intra
CLDN4 O14493 MFSD14B Homo sapiens Q5SR56
Y2H Array
32296183
Intra
CLDN4 O14493 MFSD14B Homo sapiens Q5SR56
Y2H Prey Pooling
32296183
Intra
CLDN4 O14493 GOLM1 Homo sapiens Q8NBJ4
Y2H Prey Pooling
32296183
Intra
CLDN4 O14493 GOLM1 Homo sapiens Q8NBJ4
Validated Y2H
32296183
Intra
CLDN4 O14493 GOLM1 Homo sapiens Q8NBJ4
Y2H Array
32296183
Intra
CLDN4 O14493 ICAM3 Homo sapiens P32942
Y2H Array
32296183
Intra
CLDN4 O14493 ICAM3 Homo sapiens P32942
Y2H Prey Pooling
32296183
Intra
CLDN4 O14493 ICAM3 Homo sapiens P32942
Validated Y2H
32296183
Intra
CLDN4 O14493 SYT2 Homo sapiens Q8N9I0
Y2H Prey Pooling
32296183
Intra
CLDN4 O14493 SYT2 Homo sapiens Q8N9I0
Validated Y2H
32296183
Intra
CLDN4 O14493 SYT2 Homo sapiens Q8N9I0
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant CLDN4 Proteins

Cat. No. Product Name Accession Purity
HY-P700405 Claudin-4/CLDN4 Protein-VLP, Human (HEK293, His) O14493 (M1-V209) Purity analysis by SDS-PAGE is not available for VLP proteins.

CLDN4 Antibodies

Cat. No. Product Name Application Reactivity
HY-P81606 Claudin 4 Antibody (YA1351) WB, IHC-P, IP Human
HY-P81606A Claudin 4 Antibody (YA1351)(PBS only) WB, IHC-P, IP Human, Mouse
HY-P85954 Claudin 4 Antibody (YA5646) IHC-P, WB, ICC/IF, ELISA Human

Related Diseases

Diseases Alias
Ovarian Cystadenoma

  • Cystoma Serosum Simplex

  • Simple Cystoma Of Ovary

  • Simple Cystoma Of The Ovary
Williams-Beuren Syndrome

  • Williams Syndrome

  • WBS

  • Wms

  • Deletion 7q11.23

  • Monosomy 7q11.23

  • Chromosome 7q11.23 Deletion Syndrome, 1.5- To 1.8-Mb

  • Fanconi Schlesinger Syndrome

  • Beuren Syndrome

  • Elfin Facies Syndrome

  • Elfin Facies With Hypercalcemia

  • Hypercalcemia-Supravalvar Aortic Stenosis

  • Ws
Breast Carcinoma In Situ

  • Carcinoma In Situ Of Breast

  • Non-Infiltrating Carcinoma Of Breast

  • Breast Cancer In Situ
Papillary Carcinoma

  • Carcinoma, Papillary

  • Carcinoma Papillary
Peritoneal Serous Papillary Adenocarcinoma

  • Primary Serous Papillary Carcinoma Of Peritoneum
Ovarian Cancer

  • Ovarian Carcinoma

  • Ovarian Neoplasm

  • Malignant Tumour Of Ovary

  • Cancer Of The Ovary

  • Epithelial Ovarian Cancer

  • Neoplasm Of Ovary

  • Ovarian Neoplasms

  • Ovarian Cancers

  • Malignant Neoplasm Of Ovary

  • Primary Malignant Neoplasm Of Ovary

  • Ovarian Cancer, Somatic

  • Malignant Ovarian Tumor

  • Ovary Neoplasm

  • Primary Ovarian Cancer

  • Tumor Of The Ovary

  • Malignant Neoplasm Of The Ovary

  • Malignant Tumor Of The Ovary

  • Ovarian Malignant Tumor

  • OC

  • Ovarian Carcinomas

  • Cancer, Ovarian

  • Cancer Of Ovary

  • Ovary Cancer

  • Ca Ovary
Gastric Adenocarcinoma

  • Adenocarcinoma Of Stomach

  • Stomach Adenocarcinoma

  • Adenocarcinoma Gastric

  • Intestinal Type Adenocarcinoma Of Unspecified Site

  • Diffuse Type Adenocarcinoma Of Unspecified Site
Inflammatory Bowel Disease 20

  • IBD20
Smarca4-Deficient Sarcoma Of Thorax

  • Smarca4-Dts

  • Smarca4-Deficient Thoracic Sarcoma
Gastric Cancer

  • Stomach Cancer

  • Gastric Carcinoma

  • Stomach Carcinoma

  • Gastric Cancer, Somatic

  • Gastric Neoplasm

  • Carcinoma Of Stomach

  • Stomach Neoplasms

  • Malignant Neoplasm Of Stomach

  • Gastric Cancer Risk After H. Pylori Infection

  • Cancer Of The Stomach

  • Adult Stomach Cancer

  • Adult Stomach Carcinoma

  • GASC

  • Gastric Cancer Intestinal

  • Gastric Cancers

  • Gastric Carcinomas

  • Cancer, Gastric

  • Stomach Neoplasm

  • Malignant Neoplasm Of Body Of Stomach

  • Malignant Tumor Of Lesser Curve Of Stomach

  • Gastrocarcinoma Of Unspecified Site

  • Leather Bottle Stomach

  • Carcinoma Of Fundus Of Stomach

  • Cancer Of Fundus Of Stomach

  • Primary Malignant Neoplasm Of Body Of Stomach

  • Cancer Of Body Of Stomach

  • Primary Malignant Neoplasm Of Pyloric Antrum

  • Pyloric Antrum Cancer

  • Malignant Tumour Of Stomach
Sarcomatoid Mesothelioma

  • Malignant Fibrous Mesothelioma

  • Spindled Mesothelioma
Endometrial Cancer

  • Endometrial Carcinoma

  • Endometrial Neoplasm

  • Malignant Neoplasm Of Endometrium

  • Endometrioid Carcinoma

  • Endometrial Neoplasms

  • Carcinoma, Endometrioid

  • Endometrial Cancer, Familial

  • Endometrial Carcinoma, Somatic

  • Endometrial Cancer, Susceptibility To

  • Endometrial Ca

  • Malignant Endometrial Neoplasm

  • Neoplasm Of Endometrium

  • Primary Malignant Neoplasm Of Endometrium

  • Tumor Of Endometrium

  • Carcinoma Of The Endometrium

  • Endometrioid Carcinoma Of Female Reproductive System

  • ENDMC

  • Carcinoma Endometrioid

  • Endometrial Cancers

  • Cancer, Endometrial

  • Uterine Corpus Cancer
Pancreatic Cancer

  • Pancreatic Carcinoma

  • Carcinoma Of Pancreas

  • Familial Pancreatic Carcinoma

  • Pancreatic Neoplasm

  • Pancreatic Carcinoma, Familial

  • Malignant Neoplasm Of Pancreas

  • Pancreatic Acinar Carcinoma

  • Pancreatic Tumor

  • Familial Pancreatic Cancer

  • Neoplasm Of The Pancreas

  • Cancer Of The Pancreas

  • Pancreatic Carcinoma, Somatic

  • Pancreatic Cancer, Somatic

  • Ca Body Of Pancreas

  • Ca Head Of Pancreas

  • Ca Tail Of Pancreas

  • Malignant Neoplasm Of Body Of Pancreas

  • Malignant Neoplasm Of Head Of Pancreas

  • Malignant Neoplasm Of Tail Of Pancreas

  • Pancreas Neoplasm

  • Exocrine Cancer

  • Exocrine Pancreas Carcinoma

  • Hereditary Pancreatic Cancer

  • Hereditary Pancreatic Carcinoma

  • PNCA

  • Pancreatic Cancer, Susceptibility To

  • Carcinoma Of Head Of Pancreas

  • Pancreatic Neoplasms

  • Pancreatic Tumors

  • Cancer, Pancreatic

  • Cancer Of Pancreas

  • Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site
Collagenous Colitis

  • Colitis, Collagenous

  • Microscopic Colitis, Collagenous Type
Peritoneal Serous Adenocarcinoma

  • Primary Peritoneal Serous Adenocarcinoma
Colorectal Cancer

  • Colon Cancer

  • Colorectal Carcinoma

  • Colon Carcinoma

  • Colorectal Cancer, Susceptibility To

  • Carcinoma Of Colon

  • CRC

  • Colorectal Cancer With Chromosomal Instability, Somatic

  • Colon Cancer, Somatic

  • Colon Cancer, Susceptibility To

  • Colonic Neoplasms

  • Colorectal Neoplasms

  • Colorectal Cancer, Somatic

  • Colon Cancer, Advanced, Somatic

  • Colonic Carcinoma

  • Colorectal Carcinomas

  • Colon Cancers

  • Colorectal Cancers

  • Cancer, Colorectal, Somatic

  • Cancer, Colon

  • Cancer, Colorectal, Susceptibility To

  • Colorectal Neoplasm

  • Colonic Neoplasm

  • Malignant Tumor Of Colon
Large Cell Carcinoma With Rhabdoid Phenotype

  • Large Cell Lung Carcinoma With Rhabdoid Phenotype
Corneal Dystrophy, Posterior Polymorphous, 4

  • PPCD4

  • Posterior Polymorphous Corneal Dystrophy 4
Diarrhea

  • Diarrhoea

  • Diarrhea Of Presumed Infectious Origin
Lymphohistiocytoid Mesothelioma
Inflammatory Bowel Disease

  • Inflammatory Bowel Diseases

  • Bowel Disease, Inflammatory
Breast Cancer

  • Breast Carcinoma

  • Male Breast Cancer

  • Breast Cancer, Familial

  • Malignant Neoplasm Of Breast

  • Breast Cancer, Susceptibility To

  • Breast Cancer, Early-Onset

  • Malignant Tumor Of Breast

  • Carcinoma Of Male Breast

  • Breast Cancer, Invasive Ductal

  • Breast Cancer, Protection Against

  • Breast Cancer, Somatic

  • Breast Cancer, Male

  • Breast Cancer, Lobular, Somatic

  • Breast Tumor

  • Mammary Cancer

  • Mammary Tumor

  • Malignant Neoplasm Of Male Breast

  • Mammary Carcinoma

  • Male Breast Carcinoma

  • Familial Cancer Of Breast

  • Invasive Ductal Breast Carcinoma

  • Breast Cancer Susceptibility

  • Breast Cancer, Male, Susceptibility To

  • Breast Cancer, Early-Onset, Susceptibility To

  • Malignant Tumor Of The Breast

  • Mammary Neoplasm

  • Primary Breast Cancer

  • Neoplasm Of Male Breast

  • Carcinoma Of Breast

  • Breast Cancer In Men

  • Familial Breast Cancer

  • Cancer Of Breast

  • BC

  • Breast Cancer Familial

  • Breast Cancer Familial Male

  • Breast Cancer, Familial Male

  • Breast Male Carcinoma

  • Breast Neoplasms

  • Breast Neoplasms, Male

  • Mammary Tumors

  • Mammary Carcinomas

  • Cancer, Breast

  • Cancer, Breast, Susceptibility

  • Invasive Breast Ductal Carcinoma

  • Breast Neoplasm

  • Susceptibility To Breast Cancer

  • Mammary Neoplasms

  • Animal Mammary Neoplasms

  • Primary Malignant Neoplasm Of Breast

  • Infiltrating Ductal Carcinoma Of Breast

  • Infiltrating Duct Carcinoma Of Unspecified Site

  • Infiltrating Ductular Carcinoma Of Unspecified Site

  • Invasive Breast Carcinoma Of No Special Type

  • Microinvasive Carcinoma Of Breast

  • Carcinoma With Apocrine Differentiation
Celiac Disease 1

  • Celiac Disease

  • Coeliac Disease

  • Celiac Sprue

  • Celiac Disease, Susceptibility To

  • Gluten-Sensitive Enteropathy

  • Nontropical Sprue

  • Sprue

  • CELIAC1

  • Celiac Disease, Susceptibility To, 1

  • Celiac Sprue 1

  • Celiac Sprue, Susceptibility To, 1

  • Gluten-Sensitive Enteropathy 1

  • Gluten-Sensitive Enteropathy, Susceptibility To, 1

  • Idiopathic Steatorrhea

  • Cœliac Disease

  • Gluten Intolerance

  • Gluten-Induced Enteropathy

  • Gluten Enteropathy

  • Celiac Disease, Susceptibility To, Type 1

  • Childhood Celiac Disease

  • Coeliac Rickets

  • Gee Disease

  • Gee-Herter Disease

  • Heubner-Herter Disease

  • Idiopathic Steatorrhoea

  • Thaysen'S Disease

  • Herter Gee Syndrome
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS02772 CLDN4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-P11785 Cpe30 MT2 Ligand / Unkown
HY-RS21532 Cldn4 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28050 Cldn4 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris CLDN4 VGNC VGNC:39321
Macaca mulatta CLDN4 VGNC VGNC:80864
Rattus norvegicus CLDN4 RGD RGD:1307932
Felis catus CLDN4 VGNC VGNC:60937
Bos taurus CLDN4 VGNC VGNC:27416
Mus musculus CLDN4 MGD MGI:1313314
Others CLDN4 NCBI