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Claudin 4 Antibody (YA1351)(PBS only)

(Synonyms: CLDN4; CPER; CPETR1; WBSCR8; Claudin-4; Clostridium perfringens enterotoxin receptor; CPE-R; CPE-receptor; Williams-Beuren syndrome chromosomal region 8 protein)
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Claudin 4 Antibody (YA1351) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Claudin 4.

For research use only. We do not sell to patients.
  • Host:

    Rabbit

  • Isotype:

    IgG

  • Application:

    WB, IHC-P, IP

  • Reactivity :

    Human, Mouse

  • Formulation:

    Supplied in PBS, pH 7.4.

  • Conjugation:
    Non-conjugated
  • Claudin 4 Antibody (YA1351)(PBS only) Product Image
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To place orders, for customer services and technical support, please contact: MedChemExpress USA

Tel: 609-228-6898 E-mail: [email protected] [email protected]

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Applications

Application
WB Info
WB: Western Blot
IHC-P Info
IHC-P: Immunohistochemistry-Paraffin
IP Info
IP: Immunoprecipitation
Dilution Ratio 1:500-1:1000 1:500-1:2000 1:20-1:50

Product Details

Description

Claudin 4 Antibody (YA1351) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Claudin 4.

  • Host Rabbit
  • Species Reactivity
    Human, Mouse
  • Observed Molecular Weight
    Observed band size: 18 kDa Info
    Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
  • Calculated Molecular Weight Predicted band size: 22 kDa
Immunogen

A synthesized peptide derived from human Claudin 4

Purification

Affinity Chromatography

Conjugation

Non-conjugated

Isotype

IgG

Product Properties

  • Appearance

    Solution

  • Formulation

    Supplied in PBS, pH 7.4.

  • Concentration

    Batch-dependent, Please check the COA for the concentration of each lot. Check Lot Concentration

  • Storage & Stability

    Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

  • Shipping

    Shipping with blue ice.

Background

  • Function

    Claudin 4 is a Can associate with other claudins to regulate tight junction structural and functional strand dynamics. May coassemble with CLDN8 into tight junction strands containing anion-selective channels that convey paracellular chloride permeability in renal collecting ducts. May integrate into CLDN3 strands to modulate localized tight junction barrier properties. May disrupt strand assembly of channel-forming CLDN2 and CLDN15 and inhibit cation conductance. Cannot form tight junction strands on its own[1][2].

  • Subcellular Localization

    Cell junction, tight junction; Cell membrane; Multi-pass membrane protein

  • Subunit

    Can form heteropolymeric strands with other claudins (PubMed:36008380). Interacts with CLDN8 (By similarity). Interacts with CLDN1 (PubMed:20375010). Directly interacts with TJP1/ZO-1 (PubMed:16236711). Interacts with TJP2/ZO-2 and TJP3/ZO-3 (By similarity). Interacts with EPHA2; phosphorylates CLDN4 and may regulate tight junctions (PubMed:16236711)

  • SwissProt ID

    O14493

  • Gene ID
    1364 [NCBI]
  • Synonyms

    CLDN4; CPER; CPETR1; WBSCR8; Claudin-4; Clostridium perfringens enterotoxin receptor; CPE-R; CPE-receptor; Williams-Beuren syndrome chromosomal region 8 protein

  • Research Field

    Cell Biology

References

[1]. Shashikanth N, et al. Tight junction channel regulation by interclaudin interference. Nat Commun. 2022 Jun 30;13(1):3780. [Content Brief]

[2]. Gonschior H, et al. Nanoscale segregation of channel and barrier claudins enables paracellular ion flux. Nat Commun. 2022 Aug 25;13(1):4985.

Claudin 4 Antibody (YA1351)(PBS only) Related Classifications

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100 mg

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Measured by its ability to inhibit anti-CD3-induced proliferation of stimulated CTLL-2 mouse cytotoxic T cells. The ED50 this effect is 0.8023 μg/ml, corresponding to a specific activity is 1246.42 units/mg.

Assay Types
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  • Claudin 4 Antibody (YA1351)(PBS only) Product Image