Dmbt1 - deleted in malignant brain tumors 1 Gene

Also Known as CRP; p80; Crpd; DBMT1; gp300; CRP-[a]; CRP-[b]

Species: Mus musculus

Gene Type: protein coding
Gene ID: 12945

Summary

Enables zymogen binding activity. Involved in defense response to Gram-negative bacterium and defense response to Gram-positive bacterium. Acts upstream of or within inner cell mass cell proliferation; positive regulation of epithelial cell differentiation; and response to bacterium. Located in extracellular matrix and zymogen granule membrane. Is extrinsic component of membrane. Is expressed in several structures, including central nervous system; genitourinary system; gut; retina; and spleen. Human ortholog(s) of this gene implicated in glioblastoma. Orthologous to human DMBT1 (deleted in malignant brain tumors 1). [provided by Alliance of Genome Resources, Apr 2022]

Dmbt1 Products (2)

mRNA Protein Name
NM_001347632.2 NP_001334561.1 deleted in malignant brain tumors 1 protein isoform 1 precursor
NM_007769.3 NP_031795.2 deleted in malignant brain tumors 1 protein isoform 2 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
12884308 MGI
enables zymogen binding IDA
IDA: Inferred from direct assay
15292166 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within blastocyst development IMP
IMP: Inferred from mutant phenotype
15452149 MGI
acts upstream of columnar/cuboidal epithelial cell differentiation IDA
IDA: Inferred from direct assay
15452149 MGI
involved in defense response to Gram-negative bacterium IDA
IDA: Inferred from direct assay
12884308 MGI
involved in defense response to Gram-positive bacterium IDA
IDA: Inferred from direct assay
12884308 MGI
acts upstream of or within inner cell mass cell proliferation IDA
IDA: Inferred from direct assay
15452149 MGI
acts upstream of or within positive regulation of epithelial cell differentiation IDA
IDA: Inferred from direct assay
15452149 MGI
acts upstream of or within response to bacterium IEP
IEP: Inferred from expression pattern
23012479 MGI
Cellular Component GO Annotation Evidence References Source
located in extracellular matrix IDA
IDA: Inferred from direct assay
9247472 MGI
located in intracellular anatomical structure IDA
IDA: Inferred from direct assay
15452149 MGI
located in zymogen granule membrane IDA
IDA: Inferred from direct assay
7876332 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

deleted in malignant brain tumors 1 protein

  • apactin

  • crp-ductin

  • deleted in malignant brain tumors 1 pseudogene

  • ebnerin

  • glycoprotein 300

  • hensin

  • mucin-like glycoprotein

  • muclin

  • vomeroglandin

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS03820 DMBT1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19428 Dmbt1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25919 Dmbt1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Dmbt1 NCBI NCBI:1755