ADH6 - alcohol dehydrogenase 6 (class V) Gene

Also Known as ADH-5

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 130

About ADH6

Cytogenetic location: 4q23 Genomic coordinates (GRCh38): 4:99,202,639-99,219,246 (from NCBI)

This gene has 8 transcripts (splice variants), 375 orthologues and 17 paralogues. Biased expression in liver (RPKM 139.0), duodenum (RPKM 20.7) and 2 other tissues.

Summary

This gene encodes class V alcohol dehydrogenase, which is a member of the alcohol dehydrogenase family. Members of this family metabolize a wide variety of substrates, including ethanol, retinol, Other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. This gene is expressed in the stomach as well as in the liver, and it contains a glucocorticoid response element upstream of its 5' UTR, which is a steroid hormone receptor binding site. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

ADH6 Products (2)

mRNA Protein Name
NM_000672.4 NP_000663.1 alcohol dehydrogenase 6 isoform 2
NM_001102470.2 NP_001095940.1 alcohol dehydrogenase 6 isoform 1

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables alcohol dehydrogenase (NAD+) activity IDA
IDA: Inferred from direct assay
1755855 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ADH6 Protein Structure

ADH_N

ADH_N: Alcohol dehydrogenase GroES-like domain (35 - 160)

ADH_zinc_N

ADH_zinc_N: Zinc-binding dehydrogenase (203 - 331)

  • 0
  • 100
  • 200
  • 300
  • 368 a.a.
Protein Preferred Names Protein Names

alcohol dehydrogenase 6

  • aldehyde reductase

Related Diseases

Diseases Alias
Proliferative Type Fibrocystic Change Of Breast

  • Fibrocystic Change, Proliferative Type With Atypia

  • Fibrocystic Disease, Proliferative Type With Atypia

  • Proliferating Lesion Of Breast Without Atypia

  • Proliferating Lesion Of The Breast Without Atypia

  • Proliferative Fibrocystic Change

  • Breast Fibrocystic Change, Proliferative Type
Amed Syndrome, Digenic

  • Amed Syndrome

  • AMEDS

  • Bone Marrow Failure Syndrome 7, Digenic

  • Bmfs7

  • Aplastic Anemia-Intellectual Disability-Dwarfism Syndrome
Breast Intraductal Proliferative Lesion

  • Intraductal Proliferative Lesion

  • Intraductal Proliferative Lesion Of The Breast
Alcohol Dependence

  • Alcoholism

  • Alcohol Dependence, Susceptibility To

  • Alcohol Dependence, Protection Against

  • Aerodigestive Tract Cancer, Squamous Cell, Alcohol-Related, Protection Against

  • Alcoholism, Susceptibility To

  • Alcoholic Intoxication, Chronic

  • Pharyngeal Neoplasms

  • Chronic Alcoholism

  • Dipsomania

  • Alcohol Addiction

  • Ethanol Dependence

  • Chronic Ethanolism

  • Chronic Alcoholic Disease Nos

  • Alcoholic Disease Nos

  • Alcoholic
Alzheimer Disease 3

  • AD3

  • Alzheimer Disease, Type 3

  • Alzheimer Disease, Type 3, With Spastic Paraparesis And Apraxia

  • Alzheimer Disease, Type 3, With Spastic Paraparesis And Unusual Plaques

  • Alzheimer'S Disease 3

  • Alzheimer Disease, Familial, 3, With Spastic Paraparesis And Apraxia

  • Alzheimer Disease 3, Early-Onset

  • Alzheimer Disease, Familial, 3

  • Alzheimer Disease, Protection Against, Due To Apoe3-Christchurch

  • Alzheimer Disease 3, Early Onset

  • Alzheimer Disease Familial 3

  • Early-Onset Familial Alzheimer Disease 3

  • Familial Alzheimer Disease 3

  • Familial Alzheimer Disease 3 With Spastic Paraparesis And Apraxia

  • Familial Alzheimer Disease 3 With Spastic Paraparesis And Unusual Plaques

  • Alzheimer Disease, Familial, 3, With Spastic Paraparesis And Unusual Plaques

  • Alzheimer Disease, Familial, Type 3
Focal Dermal Hypoplasia

  • Goltz Syndrome

  • Goltz-Gorlin Syndrome

  • FDH

  • FODH

  • Dhof

  • Goltz Gorlin Syndrome

  • Hypoplasia, Dermal, Focal
Substance Dependence
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-145785A ADH-6 TFA 99.91% Unkown
HY-145785 ADH-6 / Unkown
HY-RS00373 ADH6 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23987 Adh6 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus ADH6 RGD RGD:1306313
Mus musculus ADH6 MGD MGI:2446626