Cst7 - cystatin F (leukocystatin) Gene

Also Known as Cmap

Species: Mus musculus

Gene Type: protein coding
Gene ID: 13011

Summary

Enables cysteine-type endopeptidase inhibitor activity. Involved in negative regulation of peptidase activity. Acts upstream of or within inhibition of cysteine-type endopeptidase activity; negative regulation of microglial cell activation; and positive regulation of myelination. Located in several cellular components, including Golgi apparatus; late endosome; and lysosome. Is expressed in several structures, including early conceptus and female reproductive system. Orthologous to human CST7 (Cystatin F). [provided by Alliance of Genome Resources, Apr 2022]

Cst7 Products (1)

mRNA Protein Name
NM_009977.3 NP_034107.2 cystatin-F precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables cysteine-type endopeptidase inhibitor activity IMP
IMP: Inferred from mutant phenotype
28251676 MGI
enables peptidase inhibitor activity IDA
IDA: Inferred from direct assay
18256700 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within inhibition of cysteine-type endopeptidase activity IMP
IMP: Inferred from mutant phenotype
28251676 MGI
acts upstream of or within negative regulation of microglial cell activation IMP
IMP: Inferred from mutant phenotype
28251676 MGI
involved in negative regulation of peptidase activity IDA
IDA: Inferred from direct assay
18256700 MGI
acts upstream of or within positive regulation of myelination IMP
IMP: Inferred from mutant phenotype
28251676 MGI
Cellular Component GO Annotation Evidence References Source
located in Golgi apparatus IDA
IDA: Inferred from direct assay
18256700 MGI
located in cytoplasm IDA
IDA: Inferred from direct assay
28251676 MGI
located in cytoplasmic vesicle IMP
IMP: Inferred from mutant phenotype
15212960 MGI
located in endoplasmic reticulum IMP
IMP: Inferred from mutant phenotype
15212960 MGI
located in extracellular space IDA
IDA: Inferred from direct assay
28178353 MGI
located in late endosome IMP
IMP: Inferred from mutant phenotype
15212960 MGI
located in lysosome IMP
IMP: Inferred from mutant phenotype
15212960 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

cystatin-F

  • cystatin-7

  • cystatin-like metastasis-associated protein

Recombinant Cst7 Proteins

Cat. No. Product Name Accession Purity
HY-P7853 Cystatin F/CST7 Protein, Mouse (HEK293, His) O89098 (A19-Q144) ≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS03268 CST7 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18469 Cst7 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24950 Cst7 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Cst7 NCBI NCBI:8530