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Ctcf - CCCTC-binding factor Gene

Species: Mus musculus

Gene Type: protein coding

Gene ID: 13018

Summary

Enables chromatin binding activity and sequence-specific DNA binding activity. Involved in regulation of gene expression and regulation of histone modification. Acts upstream of or within DNA metabolic process and regulation of gene expression. Located in nucleus. Is expressed in several structures, including alimentary system; central nervous system; early conceptus; genitourinary system; and limb. Human ortholog(s) of this gene implicated in autosomal dominant non-syndromic intellectual disability 21. Orthologous to human CTCF (CCCTC-binding factor). [provided by Alliance of Genome Resources, Apr 2022]

Ctcf Products (12)

mRNA	Protein	Name
NM_001358924.2	NP_001345853.1	transcriptional repressor CTCF isoform 2
NM_001403723.1	NP_001390652.1	transcriptional repressor CTCF isoform 1
NM_001403724.1	NP_001390653.1	transcriptional repressor CTCF isoform 1
NM_001403725.1	NP_001390654.1	transcriptional repressor CTCF isoform 1
NM_001403726.1	NP_001390655.1	transcriptional repressor CTCF isoform 2
NM_001403727.1	NP_001390656.1	transcriptional repressor CTCF isoform 2
NM_001403728.1	NP_001390657.1	transcriptional repressor CTCF isoform 2
NM_001403729.1	NP_001390658.1	transcriptional repressor CTCF isoform 3
NM_001403730.1	NP_001390659.1	transcriptional repressor CTCF isoform 3
NM_001403731.1	NP_001390660.1	transcriptional repressor CTCF isoform 4
NM_001403732.1	NP_001390661.1	transcriptional repressor CTCF isoform 4
NM_181322.4	NP_851839.1	transcriptional repressor CTCF isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables DNA binding	IDA IDA: Inferred from direct assay	12461525	MGI
enables chromatin binding	IDA IDA: Inferred from direct assay	22780989	MGI
enables cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	28636939	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	16949368	MGI
enables sequence-specific DNA binding	IDA IDA: Inferred from direct assay	11743158	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within DNA methylation-dependent heterochromatin formation	IMP IMP: Inferred from mutant phenotype	24105743	MGI
acts upstream of or within cardiac muscle cell development	IMP IMP: Inferred from mutant phenotype	28846746	MGI
acts upstream of or within cardiac muscle cell differentiation	IMP IMP: Inferred from mutant phenotype	28846746	MGI
involved in chromatin looping	IDA IDA: Inferred from direct assay	28388437	MGI
involved in chromatin looping	IMP IMP: Inferred from mutant phenotype	16951251	MGI
acts upstream of or within chromatin organization	IMP IMP: Inferred from mutant phenotype	28846746	MGI
acts upstream of or within epigenetic regulation of gene expression	IDA IDA: Inferred from direct assay	12461525	MGI
acts upstream of or within gene expression	IMP IMP: Inferred from mutant phenotype	28846746	MGI
acts upstream of or within genomic imprinting	IDA IDA: Inferred from direct assay	12461525	MGI
acts upstream of or within genomic imprinting	IMP IMP: Inferred from mutant phenotype	14716017	MGI
acts upstream of or within heart development	IMP IMP: Inferred from mutant phenotype	28846746	MGI
acts upstream of or within in utero embryonic development	IMP IMP: Inferred from mutant phenotype	28846746	MGI
acts upstream of or within mitochondrion organization	IMP IMP: Inferred from mutant phenotype	28846746	MGI
involved in negative regulation of gene expression	IMP IMP: Inferred from mutant phenotype	18614575	MGI
acts upstream of or within negative regulation of gene expression via chromosomal CpG island methylation	IMP IMP: Inferred from mutant phenotype	14716017	MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	24105743	MGI
involved in positive regulation of gene expression	IMP IMP: Inferred from mutant phenotype	18614575	MGI
acts upstream of or within regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	15143173	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in male germ cell nucleus	IDA IDA: Inferred from direct assay	12011441	MGI
located in nucleus	IDA IDA: Inferred from direct assay	12075007	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
transcriptional repressor CTCF	11-zinc finger protein CTCFL paralog

Ctcf Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	Ctcf	Q61164	Chd8	Mus musculus	Q09XV5	Y2H	16949368

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03287	CTCF Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17635	Ctcf Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24095	Ctcf Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Ctcf	NCBI	NCBI:10664