Dlk1 - delta like non-canonical Notch ligand 1 Gene

Also Known as FA1; ZOG; pG2; DlkI; Peg9; SCP1; DLK-1; Ly107; pref-1

Species: Mus musculus

Gene Type: protein coding

Gene ID: 13386

Summary

Predicted to enable calcium ion binding activity. Involved in negative regulation of fat cell differentiation and negative regulation of vascular endothelial cell proliferation. Acts upstream of or within several processes, including bone mineralization; negative regulation of Notch signaling pathway; and positive regulation of bone resorption. Located in external side of plasma membrane. Is expressed in several structures, including alimentary system; branchial arch; embryo mesenchyme; genitourinary system; and nervous system. Orthologous to human DLK1 (delta like non-canonical Notch ligand 1). [provided by Alliance of Genome Resources, Apr 2022]

Dlk1 Products (4)

mRNA	Protein	Name
NM_001190703.1	NP_001177632.1	protein delta homolog 1 isoform 2 precursor
NM_001190704.1	NP_001177633.1	protein delta homolog 1 isoform 3 precursor
NM_001190705.1	NP_001177634.1	protein delta homolog 1 isoform 4 precursor
NM_010052.5	NP_034182.2	protein delta homolog 1 isoform 1 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	24928897	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within bone mineralization	IMP IMP: Inferred from mutant phenotype	21308776	MGI
acts upstream of or within embryo development	IDA IDA: Inferred from direct assay	19247431	MGI
acts upstream of or within embryonic skeletal system development	IDA IDA: Inferred from direct assay	19247431	MGI
acts upstream of or within multicellular organism growth	IMP IMP: Inferred from mutant phenotype	21308776	MGI
acts upstream of or within negative regulation of Notch signaling pathway	IGI IGI: Inferred from genetic interaction	21419176	MGI
involved in negative regulation of fat cell differentiation	IDA IDA: Inferred from direct assay	8500166	MGI
involved in negative regulation of vascular endothelial cell proliferation	IDA IDA: Inferred from direct assay	24584117	MGI
acts upstream of or within ossification	IMP IMP: Inferred from mutant phenotype	21308776	MGI
acts upstream of or within osteoblast differentiation	IMP IMP: Inferred from mutant phenotype	21308776	MGI
acts upstream of or within positive regulation of bone resorption	IMP IMP: Inferred from mutant phenotype	21308776	MGI
acts upstream of or within positive regulation of cytokine production	IDA IDA: Inferred from direct assay	21308776	MGI
acts upstream of or within post-embryonic development	IDA IDA: Inferred from direct assay	19247431	MGI
acts upstream of or within regulation of gene expression	IMP IMP: Inferred from mutant phenotype	19515692	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in external side of plasma membrane	IDA IDA: Inferred from direct assay	18988804	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
protein delta homolog 1	adipocyte differentiation inhibitor protein delta-like 1 homolog fetal antigen 1 preadipocyte factor 1 stromal cell derived protein 1

Recombinant Dlk1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P77915	DLK-1 Protein, Mouse (HEK293, His)	Q09163-1 (A24-Q305)	≥ 95%, as determined by Bis-Tris PAGE.

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P990613	LIV-1205 (CBA-1205)		98.80%	Phase 1

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03806	DLK1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17535	Dlk1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23992	Dlk1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Inhibitory Antibodies (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P991714	Roltotatug	Inhibitor	99.332%	Unkown
HY-P992171	ADCT-701 Antibody		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Dlk1	NCBI	NCBI:8788