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Ednra - endothelin receptor type A Gene

Also Known as ETa; ET-AR; AEA001; Gpcr10; Mhdaaea1

Species: Mus musculus

Gene Type: protein coding

Gene ID: 13617

About Ednra

Chromosome 8: 78,389,660-78,451,093 reverse strand.GRCm39:CM001001.3

This gene has 2 transcripts (splice variants), 268 orthologues, 14 paralogues and is associated with 131 phenotypes. Broad expression in lung adult (RPKM 16.9), limb E14.5 (RPKM 15.1) and 25 other tissues.

Summary

Enables Endothelin Receptor activity. Involved in several processes, including cellular response to gonadotropin stimulus; circulatory system development; and neuron differentiation. Acts upstream of or within several processes, including adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway; neural crest cell development; and regulation of glucose transmembrane transport. Located in cell periphery. Is expressed in several structures, including alimentary system; branchial arch; cardiovascular system; central nervous system; and genitourinary system. Used to study mandibulofacial dysostosis with alopecia and velocardiofacial syndrome. Human ortholog(s) of this gene implicated in hypertension (multiple); lung disease; mandibulofacial dysostosis with alopecia; migraine; and obstructive sleep apnea. Orthologous to human EDNRA (Endothelin Receptor type A). [provided by Alliance of Genome Resources, Apr 2022]

Ednra Products (1)

mRNA	Protein	Name
NM_010332.2	NP_034462.1	endothelin-1 receptor precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables endothelin receptor activity	IMP IMP: Inferred from mutant phenotype	9449664	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	9449664	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	IGI IGI: Inferred from genetic interaction	15928212	MGI
involved in angiogenesis	IGI IGI: Inferred from genetic interaction	24043815	MGI
involved in aorta development	IMP IMP: Inferred from mutant phenotype	14585980	MGI
involved in atrial cardiac muscle tissue development	IMP IMP: Inferred from mutant phenotype	20929948	MGI
involved in axon extension	IMP IMP: Inferred from mutant phenotype	18401410	MGI
involved in axon guidance	IMP IMP: Inferred from mutant phenotype	18401410	MGI
involved in axonogenesis involved in innervation	IMP IMP: Inferred from mutant phenotype	24875861	MGI
involved in blood vessel remodeling	IMP IMP: Inferred from mutant phenotype	25197047	MGI
acts upstream of or within branching involved in blood vessel morphogenesis	IGI IGI: Inferred from genetic interaction	15664398	MGI
involved in branching involved in blood vessel morphogenesis	IMP IMP: Inferred from mutant phenotype	23933587	MGI
involved in calcium ion transmembrane transport	IDA IDA: Inferred from direct assay	24722437	MGI
involved in calcium ion transmembrane transport	IGI IGI: Inferred from genetic interaction	24722437	MGI
involved in calcium ion transmembrane transport	IMP IMP: Inferred from mutant phenotype	24722437	MGI
involved in canonical Wnt signaling pathway	IGI IGI: Inferred from genetic interaction	24722437	MGI
involved in cardiac chamber formation	IMP IMP: Inferred from mutant phenotype	20929948	MGI
involved in cardiac neural crest cell migration involved in outflow tract morphogenesis	IMP IMP: Inferred from mutant phenotype	31219639	MGI
involved in cellular response to follicle-stimulating hormone stimulus	IDA IDA: Inferred from direct assay	19111534	MGI
involved in cellular response to human chorionic gonadotropin stimulus	IDA IDA: Inferred from direct assay	19111534	MGI
involved in cellular response to human chorionic gonadotropin stimulus	IMP IMP: Inferred from mutant phenotype	19111534	MGI
involved in cellular response to luteinizing hormone stimulus	IDA IDA: Inferred from direct assay	19111534	MGI
involved in cellular response to oxidative stress	IMP IMP: Inferred from mutant phenotype	27899487	MGI
involved in cranial skeletal system development	IDA IDA: Inferred from direct assay	18199583	MGI
involved in cranial skeletal system development	IMP IMP: Inferred from mutant phenotype	17294360	MGI
involved in embryonic heart tube development	IGI IGI: Inferred from genetic interaction	30735130	MGI
involved in embryonic heart tube development	IMP IMP: Inferred from mutant phenotype	20929948	MGI
involved in embryonic skeletal system development	IGI IGI: Inferred from genetic interaction	19017795	MGI
involved in endothelin receptor signaling pathway	IGI IGI: Inferred from genetic interaction	24722437	MGI
involved in endothelin receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	24722437	MGI
involved in endothelin receptor signaling pathway involved in heart process	IMP IMP: Inferred from mutant phenotype	31219639	MGI
involved in establishment of endothelial barrier	IDA IDA: Inferred from direct assay	27026367	MGI
involved in face development	IDA IDA: Inferred from direct assay	18199583	MGI
involved in face development	IMP IMP: Inferred from mutant phenotype	18199583	MGI
involved in gene expression	IGI IGI: Inferred from genetic interaction	24722437	MGI
involved in gene expression	IMP IMP: Inferred from mutant phenotype	20929948	MGI
involved in glomerular endothelium development	IDA IDA: Inferred from direct assay	31402170	MGI
involved in glomerular filtration	IDA IDA: Inferred from direct assay	31402170	MGI
involved in glomerulus development	IMP IMP: Inferred from mutant phenotype	27899487	MGI
acts upstream of or within head development	IMP IMP: Inferred from mutant phenotype	15306564	MGI
acts upstream of or within heart development	IGI IGI: Inferred from genetic interaction	15664398	MGI
involved in heart development	IMP IMP: Inferred from mutant phenotype	24875861	MGI
involved in heart process	IMP IMP: Inferred from mutant phenotype	25197047	MGI
involved in heparin metabolic process	IGI IGI: Inferred from genetic interaction	27026367	MGI
acts upstream of or within in utero embryonic development	IMP IMP: Inferred from mutant phenotype	15327783	MGI
involved in left ventricular cardiac muscle tissue morphogenesis	IMP IMP: Inferred from mutant phenotype	20929948	MGI
involved in meiotic cell cycle process involved in oocyte maturation	IMP IMP: Inferred from mutant phenotype	19111534	MGI
involved in mesenchymal cell apoptotic process	IMP IMP: Inferred from mutant phenotype	17294360	MGI
involved in middle ear morphogenesis	IMP IMP: Inferred from mutant phenotype	19185569	MGI
involved in mitochondrion organization	IDA IDA: Inferred from direct assay	27899487	MGI
involved in mitotic cell cycle	IMP IMP: Inferred from mutant phenotype	20929948	MGI
acts upstream of or within neural crest cell development	IMP IMP: Inferred from mutant phenotype	9449664	MGI
involved in neural crest cell differentiation	IGI IGI: Inferred from genetic interaction	28455376	MGI
involved in neural crest cell differentiation	IMP IMP: Inferred from mutant phenotype	19185569	MGI
involved in neural crest cell fate commitment	IMP IMP: Inferred from mutant phenotype	17294360	MGI
involved in neuromuscular process	IMP IMP: Inferred from mutant phenotype	19017795	MGI
involved in neuron projection development	IMP IMP: Inferred from mutant phenotype	24875861	MGI
involved in neuron remodeling	IMP IMP: Inferred from mutant phenotype	19017795	MGI
involved in noradrenergic neuron differentiation	IMP IMP: Inferred from mutant phenotype	24875861	MGI
involved in norepinephrine metabolic process	IMP IMP: Inferred from mutant phenotype	25197047	MGI
involved in pharyngeal arch artery morphogenesis	IMP IMP: Inferred from mutant phenotype	23933587	MGI
involved in podocyte apoptotic process	IMP IMP: Inferred from mutant phenotype	27899487	MGI
involved in podocyte differentiation	IDA IDA: Inferred from direct assay	31402170	MGI
involved in podocyte differentiation	IGI IGI: Inferred from genetic interaction	24722437	MGI
involved in positive regulation of canonical NF-kappaB signal transduction	IMP IMP: Inferred from mutant phenotype	24722437	MGI
involved in protein phosphorylation	IMP IMP: Inferred from mutant phenotype	31219639	MGI
involved in protein transmembrane transport	IDA IDA: Inferred from direct assay	27026367	MGI
acts upstream of or within regulation of D-glucose transmembrane transport	IDA IDA: Inferred from direct assay	11546805	MGI
involved in regulation of blood pressure	IGI IGI: Inferred from genetic interaction	16399858	MGI
NOT acts upstream of or within regulation of blood pressure	IMP IMP: Inferred from mutant phenotype	15928212	MGI
involved in regulation of blood pressure	IMP IMP: Inferred from mutant phenotype	16399858	MGI
involved in regulation of heart rate	IGI IGI: Inferred from genetic interaction	16399858	MGI
involved in regulation of heart rate	IMP IMP: Inferred from mutant phenotype	16399858	MGI
involved in regulation of protein localization to cell leading edge	IMP IMP: Inferred from mutant phenotype	31219639	MGI
involved in renal albumin absorption	IDA IDA: Inferred from direct assay	31402170	MGI
involved in renal albumin absorption	IGI IGI: Inferred from genetic interaction	24722437	MGI
involved in renal albumin absorption	IMP IMP: Inferred from mutant phenotype	27899487	MGI
involved in renal sodium ion absorption	IMP IMP: Inferred from mutant phenotype	23698114	MGI
acts upstream of or within respiratory gaseous exchange by respiratory system	IMP IMP: Inferred from mutant phenotype	9449664	MGI
involved in response to acetylcholine	IMP IMP: Inferred from mutant phenotype	26531127	MGI
involved in response to amphetamine	IMP IMP: Inferred from mutant phenotype	24875861	MGI
acts upstream of or within response to hypoxia	IMP IMP: Inferred from mutant phenotype	9449664	MGI
involved in response to wounding	IMP IMP: Inferred from mutant phenotype	25197047	MGI
involved in semaphorin-plexin signaling pathway involved in axon guidance	IMP IMP: Inferred from mutant phenotype	30735130	MGI
involved in sodium ion homeostasis	IGI IGI: Inferred from genetic interaction	18784261	MGI
involved in specification of segmental identity, mandibular segment	IMP IMP: Inferred from mutant phenotype	19017795	MGI
involved in specification of segmental identity, maxillary segment	IMP IMP: Inferred from mutant phenotype	19017795	MGI
involved in sympathetic nervous system development	IMP IMP: Inferred from mutant phenotype	25197047	MGI
involved in sympathetic neuron axon guidance	IGI IGI: Inferred from genetic interaction	30735130	MGI
involved in thyroid gland development	IMP IMP: Inferred from mutant phenotype	26506449	MGI
involved in vascular associated smooth muscle cell development	IMP IMP: Inferred from mutant phenotype	24412386	MGI
acts upstream of or within vasoconstriction	IMP IMP: Inferred from mutant phenotype	9826706	MGI

Cellular Component GO Annotation	Evidence	References	Source
is active in cell periphery	IDA IDA: Inferred from direct assay	30990108	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Ednra Protein Structure

7tmA_ET-AR

0
100
200
300
400
427 a.a.

Protein Preferred Names	Protein Names
endothelin-1 receptor	ET-A G-protein coupled receptor 10 endothelin A receptor

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P990089	Patecibart	Antagonist	97.77%	Phase 1

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04166	EDNRA Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS04167	Ednra Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS04168	EDNRA Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS04171	Ednrb Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Ednra	NCBI	NCBI:1909