Ednra - endothelin receptor type A Gene

Mus musculus

Also known as ETa; ET-AR; AEA001; Gpcr10; Mhdaaea1

Gene ID: 13617 | Gene type: protein coding

About Ednra

Chromosome 8: 78,389,660-78,451,093 reverse strand.GRCm39:CM001001.3

This gene has 2 transcripts (splice variants), 268 orthologues, 14 paralogues and is associated with 131 phenotypes. Broad expression in lung adult (RPKM 16.9), limb E14.5 (RPKM 15.1) and 25 other tissues.

Summary

Enables Endothelin Receptor activity. Involved in several processes, including cellular response to gonadotropin stimulus; circulatory system development; and neuron differentiation. Acts upstream of or within several processes, including adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway; neural crest cell development; and regulation of glucose transmembrane transport. Located in cell periphery. Is expressed in several structures, including alimentary system; branchial arch; cardiovascular system; central nervous system; and genitourinary system. Used to study mandibulofacial dysostosis with alopecia and velocardiofacial syndrome. Human ortholog(s) of this gene implicated in hypertension (multiple); lung disease; mandibulofacial dysostosis with alopecia; migraine; and obstructive sleep apnea. Orthologous to human EDNRA (Endothelin Receptor type A). [provided by Alliance of Genome Resources, Apr 2022]

Ednra Products(1)

mRNA	Protein	Name
NM_010332.2	NP_034462.1	endothelin-1 receptor precursor

Ednra Protein Structure

7tmA_ET-AR

0
100
200
300
400
427 a.a.

Protein Preferred Names

Protein Names

endothelin-1 receptor

ET-A	G-protein coupled receptor 10
endothelin A receptor

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Purity	Rare Diseases
HY-RS04166	EDNRA Human Pre-designed siRNA Set A	/	Unkown
HY-RS04167	Ednra Mouse Pre-designed siRNA Set A	/	Unkown
HY-RS04168	EDNRA Rat Pre-designed siRNA Set A	/	Unkown

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P990089	Patecibart	Antagonist	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Ednra	NCBI	NCBI:1909

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